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9034916 Pharmaceutical composition for the prevention or treatment of a neurodegenerative disease, comprising a Daphne genkwa extract or a compound isolated therefrom  
The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired...
9023371 Drug releasing coatings for medical devices  
Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic...
9023887 Lipase inhibitors for the treatment of pancreatitis and organ failure  
The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor....
9018259 Treatment of cancer using benzoic acid derivatives  
The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are...
9018246 Transmucosal administration of taxanes  
The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual...
9012475 Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor  
A method for treating a tumor by combining a piperidine compound of formula (I) or salt thereof and a microtubule-targeting drug, in which the microtubule-targeting drug is administered once per 7...
9011896 Coating formulations for scoring or cutting balloon catheters  
The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive...
9005161 Drug releasing coatings for medical devices  
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a...
8993618 Composition for treating influenza A (H1N1) virus and a preparation method therefor  
New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly...
8987223 Treatment of pulmonary and pleural fibrosis using HSP27 inhibitors  
Reduction of HSP27 expression is in beneficial in the treatment of pleural and pulmonary fibrosis and in particular subpleural fibrosis and IPF. Pharmaceutical compositions for this purpose...
8987323 Crystalline form of benzylbenzene SGLT2 inhibitor  
Provided are crystalline forms of a compound having an inhibitory effect on sodium-dependent glucose cotransporter SGLT2. The invention also provides pharmaceutical compositions, methods of...
8962679 Daidzein analogs as treatment for cancer  
Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer...
8957111 Strontium (M) ascorbate, compositions containing same, method for making same and method of using same  
A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a...
8952056 Methods for inhibiting drug degradation  
Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450....
8945627 Micelles for the solubilization of gossypol  
The invention provides biocompatible micelles loaded with one or more active agents. The micelles can encapsulate anticancer drugs such as gossypol, and combinations of drugs, such as gossypol and...
8940786 Non-aqueous taxane nanodispersion formulations and methods of using the same  
Non-aqueous, ethanol-free taxane nanodispersion formulations are provided. Nanodispersion formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a...
8940301 Breast tumor treatment with anti-CXCR1 compositions  
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional...
8933116 Gamma secretase inhibitors  
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein each of the substituents is given the definition as set forth in the specification and claims....
8927593 Benzofuran compounds for the treatment of hepatitis C virus infections  
The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral...
8927592 Antitumoral use of cabazitaxel  
The invention relates to a compound of formula: which may be in base form or in the form of a hydrate or a solvate, in combination with prednisone or prednisolone, for its use as a medicament in...
8927019 Methods and compositions for treating recurrent cancer  
The present invention provides methods of treating recurrent cancer (such as recurrent ovarian, peritoneal, or fallopian tube cancer) in an individual, comprising administering to the individual...
8921411 Solid state forms of cabazitaxel and processes for preparation thereof  
The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state...
8916227 Coating of the entire surface of endoprostheses  
The present invention relates to methods for coating the entire surface of lattice-like or mesh-like endoprostheses, wherein the endoprostheses initially are being provided with a thin layer...
8916606 Therapeutic compositions and methods for targeted delivery of active agents  
The present invention pertains to therapeutic compositions that comprise: (1) a nanovector, (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are...
8912229 Taxane and abeo-taxane analogs  
The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes...
8912228 Docetaxel formulations with lipoic acid  
Pharmaceutical formulations comprising docetaxel or a pharmaceutically acceptable salt thereof, one or more solubilizers, α-lipoic acid, TPGS, one or more hydrotropes, and optionally one or more...
8900603 Local delivery of drugs from self assembled coatings  
The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of...
8877710 Methods of identifying critically ill patients at increased risk of development of organ failure and compounds for the treatment hereof  
The present invention relates to compounds for treatment that protects the endothelium, prevent pathologic thrombus formation in the microcirculation and preserve platelet number and function and...
8877746 Compositions for delivery of insoluble agents  
Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble...
8877715 Cytotoxic conjugates having neuropeptide Y receptor binding compound  
There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition...
8871802 Naphthoquinones for disease therapies  
The present invention discloses novel naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones and methods of making and using the same. The present invention also discloses...
8865189 Poly(ester amide)-based drug delivery systems  
Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming these coatings are also described.
8859616 Compounds and methods for enhancing hair growth  
The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase...
8858965 Micelle encapsulation of a combination of therapeutic agents  
The invention provides active agents, such as paclitaxel, rapamycin, or 17-DMAG, encapsulated by safe poly(ethylene glycol)-block-poly(lactic acid) (“PEG-b-PLA”) micelles. The compositions provide...
8853260 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof  
In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the...
8846110 Polymeric systems for the delivery of anticancer drugs  
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer...
8846077 High throughput fabrication of nanoparticles  
This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).
8846741 N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy  
The present invention relates to N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I), (II), (III) or (IV) or a physiologically...
8846081 Liposome compositions and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
8835478 Treatment for cancer  
The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol...
8834902 Biodegradable supporting device  
A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of...
8829004 Method for inducing tumor apoptosis by increasing nitric oxide levels  
The present invention refers to a method for inducing tumor apoptosis by influencing the ROS (reactive oxygen species) signaling pathway in tumor cells. Increasing the level of ROS leads to the...
8821938 Porous drug matrices and methods of manufacture thereof  
Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices...
8815873 Heterocyclic amides as rock inhibitors  
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors...
8815275 Coatings for medical devices comprising a therapeutic agent and a metallic material  
The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular,...
8815941 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals  
Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their...
8802240 Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells  
Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also...
8796234 Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel  
In a process for forming a hydrogel, a precursor crosslinkable through disulfide bonds for forming the hydrogel is provided in a solution. The precursor comprises a branched molecular structure,...
8796327 Method for inhibiting production of cytokines of T helper cell type II and/or inhibiting production of chemokines using brazilin  
A method for inhibiting the production of cytokines of T helper cell type II (Th2 cell) and/or inhibiting the production of chemokines in a mammal is provided, wherein the method comprises...
8791152 Stable pharmaceutical composition containing docetaxel and a method of manufacturing the same  
The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a...