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RE40493 |
Porous paclitaxel matrices and methods of manufacture thereof
Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process...
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7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
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7414073 |
Cytotoxic agents containing novel potent taxanes and their therapeutic use
Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell...
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7399783 |
Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids...
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7390505 |
Nanoparticulate topiramate formulations
The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2...
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7384977 |
Water soluble paclitaxel prodrugs
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7378399 |
Avermectins substituted in the 4″ and 4′-positions having pesticidal properties
What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH 2 —CH 2 —; n is 0 or 1; R 1 , is C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl or C 2 -C 12 alkenyl; R 2 and R...
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7371747 |
Cyanoalkylamino derivatives as protease inhibitors
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical...
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7368473 |
Paclitaxel enhancer compounds
One embodiment of the present invention is a compound represented by the Structural Formula (I):
Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In...
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7361683 |
Paclitaxel aqueous injection solution and methods for preparing the same
The present invention provides an injectable pharmaceutical composition containing, as an active ingredient, paclitaxel, an anti-cancer agent. The injectable pharmaceutical composition comprises an...
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7358275 |
Internal 1,15-lactones of fluprostenol and related prostaglandin F2a analogs and their use in the treatment of glaucoma and intraocular hypertension
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The...
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7357942 |
Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are...
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7354928 |
Small molecule inhibitors targeted at Bcl-2
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-X L . In particular, the present invention provides non-peptide cell permeable small...
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7345088 |
Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, a cox-2 inhibitor and a taxol
A pharmaceutical composition for treatment of malignancies, in particular a malignant disease which is associated with the development of bone metastases or excessive bone resorption, comprises in...
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7342018 |
Urokinase inhibitors and uses thereof
The invention relates to the use of derivatives of 3-amidinophenylalanine as urokinase inhibitors for treating malignant tumors and the formation of metastases.
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7329634 |
3-Phenyl substituted 3-substituted-4ketolactams and ketolactones
The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I)
in which Q, W, X, Y, A, B and G are as defined in the disclosure, to...
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7326421 |
Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissues
An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of...
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7314637 |
Method of administering liposomal encapsulated taxane
Liposomal-encapsulated taxane or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer. The liposomal...
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7312240 |
Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents
Constrained paclitaxel derivatives include a bridge extending from the C-3′ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or...
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7276499 |
Cytotoxic agents comprising taxanes and their therapeutic use
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more...
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7276228 |
Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute...
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7256213 |
Taxanes having a C10 carbonate substituent
Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.
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7250157 |
Dermatological compositions and methods
Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin...
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RE39723 |
Semi-synthetic taxanes with antitumor and antiangiogenetic activities
Seco-baccatin III derivatives of formula:
wherein R, R 1 -R 4 , R 1 R′ , R 11 R″ , and R 111 R′″ are disclosed herein; pharmaceutical compositions comprising seco-baccatin...
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7235583 |
Fatty acid-anticancer conjugates and uses thereof
The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided.
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7232811 |
Furosemide modulators of HM74
Host cells expressing HM74 were used to obtain furosemide-like molecules with agonist activity having the following structure formula:
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7230013 |
C10 carbamoyloxy substituted taxane compositions
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7226944 |
Taxanes having a C7 carbonate substituent
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7217770 |
Stable polymeric micelle-type drug composition and method for the preparation thereof
A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7205001 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7202273 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R 1 is H, or R A CO where R A is...
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7201892 |
Pathological tissue detection and treatment employing targeted optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7199151 |
DHA-pharmaceutical agent conjugates of taxanes
The invention provides conjugates of cis-docosahexaenoic acid and pharmaceutical agents useful in treating noncentral nervous system conditions. Methods for selectively targeting pharmaceutical...
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7196115 |
Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor
The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew tree Taxus wallichiana against human cancer cell lines grown in-vitro and subsequent...
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7189753 |
Preemptive prophylaxis of migraine
A method of preventing the headache phase of migraine in a human comprises administration of a 5HT 1 receptor agonist or administration of an over-the-counter or nonprescription drug to said human...
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7186751 |
Injectable composition of paclitaxel
The disclosure concerns an injectable composition of paclitaxel, more particularly, an injectable composition of paclitaxel having excellent anticancer effect comprising solubilizer such as...
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7183312 |
Taxanes having a C7 heterosubstituted acetate substituent
Texanes having a heterosubstituted acetate substituent at C(7), a hydroxy substitutent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7183266 |
Dual induced viscosity fiber system and uses thereof
The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding a dual induced viscosity fiber system. The first component of the induced...
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7163930 |
Pharmaceutical compositions and methods relating to fucans
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160919 |
C7 lactyloxy-substituted taxanes
A taxane having the formula:
wherein X 3 is furyl, X 5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
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7157421 |
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula
where R 1 is H, C 1 –C 4 alkyl and OH; R 2 in is H, C 1 –C 4 alkyl and OH; R 3 is H and C 1 –C 4 alkyl; R 4 is H and C 1 –C 4 alkyl; n is an integer...
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7153884 |
C-2′ methylated derivatives of paclitaxel for use as antitumour agents
Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R 1 is t-butoxycarbonyl or benzoyl; R 2 is hydroxy; R 3 is hydrogen or, together with R 2 , it forms...
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7153840 |
Aqueous fludarabine phosphate composition
This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which...
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7144918 |
Biologically active macrolides, compositions, and uses thereof
The present invention provides a compound of the formula (I). The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically...
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7141540 |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said...
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7135496 |
Water soluble paclitaxel derivatives
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or...
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7119124 |
Pharmaceutical compositions containing plasma protein
The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance...
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7119075 |
Use of herbal agents for potentiation of bioefficacy of anti infectives
The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of...
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