Matches 351 - 400 out of 454 < 1 2 3 4 5 6 7 8 9 10 >
Match Document Document Title
5496846 Taxol treatment of breast cancer  
The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having breast cancer using the microtubule agent, Taxol. The present...
5489601 Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them  
Taxane derivatives having a 3' pyridyl substituted C13 side chain.
5489589 Amino acid derivatives of paclitaxel  
The present invention concerns water-soluble amino acid derivatives of paclitaxel, their use as antitumor agents, and pharmaceutical compositions containg the compounds.
5484809 Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid  
The oral delivery of many classes of drugs is facilitated by converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate derivatives....
5480639 Methods for isolating individual taxanes  
Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also...
5478860 Stable microemulsions for hydrophobic compound delivery  
Microemulsion compositions for the delivery of hydrophobic compounds are provided. Such compositions have a variety of uses. In one embodiment, the hydrophobic compounds are therapeutic agents...
5478854 Deoxy taxols  
Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of...
5474774 Adhesion inhibiting composition  
An extract prepared from plants of the genus Vaccinium, especially cranberries, which is enriched for an activity which inhibits bacterial adhesion to surfaces. The extract is also enriched for...
5470866 Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol  
The natural product cephalomannine can be converted to the important anticancer natural product taxol by a simple process involving the steps of dihydroxylation to give cephalomannine-diols, diol...
5468769 Paclitaxel derivatives  
A compound or prodrug thereof having the formula ##STR1## wherein --OR 1 comprises the C-13 side-chain of taxol and Z is selected from the group consisting of --CHO, --CH 2 OH, --CH 2 OR', --CH...
5466708 Oxetanones  
Novel compounds of the formula ##STR1## wherein Q, R 1 and R 2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of...
5447953 Biomasses to treat non-human animals  
The use of biomasses obtained in the fermentative production of lipase inhibitors, especially lipstatin, for the preparation of foodstuffs, feedstuffs, food additives, feed additives, feed...
5438072 Taxoid-based compositions  
The present invention relates to new taxoid-based compositions consisting of solutions of these derivatives in a surface-active agent. These solutions are used for preparing perfusion solutions.
5426109 Phenylnaphthalene hydroxy acids  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5426111 [Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycycloalkyl or alkoxycycloheteroalkyl]naphtho[2,3-c]furan-1(3H)-one inhibitors of 5-lipoxygenase  
Compounds of formula ##STR1## Ar is selected from (a) phenyl, (b) phenyl substituted with one or more groups selected from halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl, (c) furyl,...
5411984 Water soluble analogs and prodrugs of taxol  
Substituted 2'-benzoyl and 2', 7-dibenzoyl taxol derivatives are synthesized which have improved water solubility and stability while maintaining bioactivity. In a preferred embodiment, taxol...
5407683 Pharmaceutical solutions and emulsions containing taxol  
Compositions of matter are provided comprising a pharmaceutically effective amount of taxol or a tumor-active analog thereof solubilized in a pharmaceutically acceptable carrier comprising an oil...
5407674 Taxane having antitumor activity  
The present invention relates to a new taxane having the structure (1), which is isolatable from root bark of plants of the Taxus genus. The compound (1) is endowed with antitumor activity higher...
5403858 New compositions containing taxane derivatives  
Compositions containing taxane derivatives, consist of a solution of such derivative in a surfactant consisting of polysorbate, polyethelene glycol or hydrogenated castor oil. These compositions...
5362731 Use of piribedil derivatives and analogs for the treatment of hyperactive or unstable bladders  
Piribedil is administered to patients to treat unstable or hyperactive bladders.
5358711 Stimulation of stem cell growth by the bryostatins  
In vivo and in vitro methods are taught for stimulating the differentiation of stem cells using certain bryostatins. Stem cells can be induced to form granulocytes, macrophages and erythrocytes. In...
5356928 Cytotoxic agents  
The invention relates to pharmaceutical compositions comprising an effective cytotoxic amount of: ##STR1## Wherein R represents Ac or H; R' represents: ##STR2## OH; and R" represents: ##STR3##...
5356927 Methods of treating plasmodium and babesia parasitic infections  
Methods of inhibiting the proliferation of Plasmodium or Babesia parasites are provided by the present invention. Such methods may be useful for treating malaria and babesiosis in mammals such as...
5348979 Method of promoting nitrogen retention in humans  
Nitrogen retention in human subjects is promoted by administering β-hydroxy-β-methylbutyric acid (HMB). The amount of HMB administered is effective to conserve protein as determined by reduction...
5336684 Oxidation products of cephalomannine  
Antineoplastic taxol derivatives are derived by selective oxidation of the alkene portion of the side chain of cephalomannine. The derivative displays high activity in promoting assembly of...
5314891 Benzenesulphonamide derivatives  
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R 1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R 2 and R 3 together form --A 2 --X 2 --A 3 --...
5296506 Rearranged taxol compounds and method of using in testing of in vivo activity  
In a preferred embodiment, taxol is treated with mesyl chloride to prepare a taxol derivative with a contracted A-ring, which has comparable activity to taxol in a tubulin depolymerization assay,...
5294637 Fluoro taxols  
This invention relates to a fluorinated taxol of formula I ##STR1## in which R 1 is --COR z in which R z is RO-- or R; R g is C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 alkynyl, C 3 -6 cycloalkyl,...
5284865 Cyclohexyl substituted taxanes and pharmaceutical compositions containing them  
Taxane derivatives of the formula ##STR1## wherein R 1 is cyclohexyl, R 3 is phenyl, T 1 is hydrogen, hydroxyl protecting group, or --COT 2 , T 2 is H, C 1 -C 6 alkyl, C 2 -C 6 ...
5284864 Butenyl substituted taxanes and pharmaceutical compositions containing them  
Taxane derivatives of the formula ##STR1## wherein R 1 is butenyl, R 3 is phenyl, T 1 is hydrogen, hydroxyl protecting group, or --COT 2 , T 2 is H, C 1 -C 6 alkyl, C 2 -C 6 ...
5283253 Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them  
Taxane derivatives of the formula ##STR1## wherein R 1 is phenyl or p-nitrophenyl, R 3 is furyl or thienyl, T 1 is hydrogen, hydroxyl protecting group, or --COT 2 , T 2 is H, C 1 -C 6...
5272171 Phosphonooxy and carbonate derivatives of taxol  
The present invention is directed to novel taxol derivatives useful as anti-tumor agents. Also provided by this invention is pharmaceutical formulations and methods of treating mammalian tumors...
5262409 Binary tumor therapy  
Method for killing a cycling cell, by contacting the cell with a first agent that blocks progression of the cell cycle in the cell, and thereafter contacting the cell with a second agent that...
5260310 Oxetanone compounds and pharmaceutical compositions containing them  
Novel compounds of the formula ##STR1## wherein Q, R 1 and R 2 are described herein, are disclosed along with pharmaceutical compositions, methods of use, and process for producing compounds of...
5254580 7,8-cyclopropataxanes  
An antitumor compound of formula I ##STR1## in which R 1 is --COR z in which R z is t-butyloxy, C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 alkynyl, C 3 -6 cycloalkyl, or phenyl, optionally substituted...
5246960 Oxetanones  
Racemic compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are as described herein, enantiomers and diastereomers thereof, and salts of these esters with weak acids, are...
5234947 Potassium channel activating compounds and methods of use thereof  
A method for activating potassium channels and for treating hypertension, addiction, asthma, incontinence, and other conditions treatable by potassium channel activators, such as spasms and...
5234915 Biodegradable gel  
A new gel-like composition of matter containing a complex carbohydrate with a high degree of carboxyl substitution cross-linked by an organic cross-linker has been developed. The cross-linkers have...
5227400 Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them  
A taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT 1 , T 1 is hydrogen, hydroxyl protecting group, or --COT 2 , T 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 ...
5223532 Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives  
Non-peptidyl compounds characterized generally as chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of...
5223534 Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives  
Non-peptidyl compounds characterized generally as benzofuranyl/benzofuranylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for...
5214067 Fungicidal compositions and method  
Novel fungicidal compositions comprising a pyranyl glycine ester compound and a β-lactone compound and a method for controlling mycotic infections is disclosed.
5192796 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Fluoro taxols  
This invention relates to a fluorinated taxol of formula I ##STR1## in which R 1 is benzoyl or t-butyloxycarbonyl; R 2 is acetoxy, hydrogen or hydroxy; and the wavy line indicates either the α-...
5157049 Method of treating cancers sensitive to treatment with water soluble derivatives of taxol  
The invention involves the treatment of cancer in humans by administering water soluble derivatives of taxol. The types of cancer so treatable are those sensitive to treatment with taxol.
5132106 Halogenated pyrimidine 3-oxide derivatives, their use for the treatment and prevention of hair loss and for stimulating its regrowth  
The invention relates to compounds of formula: ##STR1## in which: R 1 and R 2 denote, independently of one another, a hydrogen atom or alternatively a carbamoyl group of formula: ##STR2## with R'...
5089492 Pharmaceuticals and dietetics containing acylamino acid derivatives  
Acylamino carboxylic acid derivatives corresponding to the formula I ##STR1## in which the groups R 1 , R 2 , R 3 , Z 1 and Z 2 represent functional groups specified in the claims. The acylamino...
5077303 Oxirane phenyl esters and fungicides containing these  
Esters of the general formula I ##STR1## where A is hydrogen, alkyl, cycloalkyl, cycloalkenyl, naphthyl, biphenyl, hetaryl or phenyl, these radicals being substituted or unsubstituted, and X is CH...
5066669 Benzofuran derivatives  
A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula:...
5059623 Substituted cycloalkyl- and heterocyclyl-carboxanilides  
A substituted cycloalkyl- or heterocyclyl-carboxanilide of the formula (I) ##STR1## in which X stands for an unsubstituted or an alkyl-substituted cycloalkyl or an unsubstituted or an...
5055485 Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides  
A process of inactivating infectious viruses in a cell-containing or a protein-containing composition containing such viruses, comprising contacting such composition with an effective amount of at...
Matches 351 - 400 out of 454 < 1 2 3 4 5 6 7 8 9 10 >