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6656509 Combination of selenium-containing compounds with cytostatics  
The present invention relates to the use of selenium and/or a derivative thereof in combination with one or more cytostatics. It is the object of the present invention to provide a possibility of...
6649632 C10 ester substituted taxanes  
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
6632795 Dolastatin-15 derivatives in combination with taxanes  
The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula I as defined herein in combination with paclitaxel, taxotere or...
6620841 Aromatic heterocycle compounds having HIV integrase inhibiting activities  
A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COOR A wherein R A is hydrogen or ester residue, —CONR B R C wherein R B and...
6610699 Use of L-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity  
Alkanoyl L-carnitines of the formula: where R is hydrogen or a C 2-8 alkanoyl group and X − is an anion of a pharmaceutically acceptable salt, are used in conjunction with anticancer agents...
6608045 Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient  
The present invention relates to Streptomyces sp. producing tautomycetin which possesses an immunosuppressive or antibacterial activities, a process for preparing tautomycetin from the said...
6602902 Dha-pharmaceutical agent conjugates to improve tissue selectivity  
The invention provides conjugates of cis-docosahexaenoic acid and pharmaceutical agents useful in treating noncentral nervous system conditions. Methods for selectively targeting pharmaceutical...
6596320 Method for treating cancer having greater efficacy and reduced adverse effects  
A method of treating patients with cancer that involves administration of a combination regimen of a platinum agent, a taxane agent, and a formula I toxicity-reducing agent. The preferred order of...
6596737 C10 carbamoyloxy substituted taxanes  
Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
6596757 Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use  
A cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a...
6593303 Anti-tumor synergetic composition  
There are provided the combined use of 4-demethoxy-3′-deamino-3′-aziridinyl-4′-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4′-methansulfonyl daunorubicin and an...
6589573 Xanthine oxidase inhibitor and method for producing the same  
In order to provide a xanthine oxidase inhibitor having as an effective component an extract from highly safe plants, ten kinds of plant materials were compared for the xanthine oxidase inhibition...
6586458 Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs  
The invention is directed to methods and compositions that can be used in the treatment of headaches. In particular, methods and compositions are described involving the combination of a...
6559178 Compositions and methods for apoptotic chemosurgery  
Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to achieve apoptotic ablation of internal organs or internal non-malignant cell populations are disclosed.
6559139 Combination chemotherapy  
This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof. In one aspect, the invention provides a method of killing a cell by first administering...
6555519 O-glucosylated benzamide SGLT2 inhibitors and method  
SGLT2 inhibiting compounds are provided having the formula wherein n is 0, 1 or 2; A is or heteroaryl which may contain 1 to 4 heteroatoms in the ring which may be selected from N, O, S, SO,...
6548524 Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors  
This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-α converting enzyme (TACE. tumor necrosis factor-α...
6541508 Taxane prodrugs  
Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.
6541509 Method for treating neoplasia using combination chemotherapy  
The present invention concerns an unexpected synergistic combination of known antineoplastic agents which provides unexpectedly greater efficacy than the single agents alone. Accordingly, the...
6537988 Synergistic methods and compositions for treating cancer  
The present invention provides a synergistic method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective...
6538019 Functional emulsions  
According to the present invention, it is possible to produce emulsions containing a material that are insoluble or that have low solubility with respect to water and oil in a high concentration,...
6538020 Paclitaxel formulation  
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: paclitaxel, a water-miscible amide and a pharmaceutically-acceptable, water-miscible solubilizer selected from...
6534539 Pharmaceutical composition and method for treatment of dyspepsia  
The present invention relates to compositions containing lipase inhibitors, e.g. orlistat, and the use of such compositions for treating, reducing or preventing functional dyspepsiaafter ingestion...
6531460 Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same  
Compounds expressed by the following general formula (1), The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid...
6528099 Method for selectively obtaining antioxidant rich extracts from citrus fruits  
A method for selectively obtaining antioxidant rich aqueous extracts from the cells, frit, core, and peels of citrus fruits, comprises a) employing water treatment and solids extraction of the...
6525087 Use of known agonists of the central cannabinoid receptor CB1  
The present invention relates to the use of known agonists of the central cannabinoid receptor CB1 for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment...
6521660 3′-alkyl substituted taxanes and pharmaceutical compositions containing them  
Taxane derivatives having an alkyl substituted C13 side chain.
6514996 Derivatives of benzofuran or benzodioxole  
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
6515016 Composition and methods of paclitaxel for treating psoriasis  
The present invention provides methods for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis, comprising the step of delivering to the site of inflammation an...
6506790 Compounds and methods  
This invention relates to substituted benzo[1,2-b:5,4-b′]dipyran-4-amines which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment...
6506799 Methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension with ether compounds  
The present invention relates to methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension comprising administering a composition comprising an ether compound.
6500859 Method for treating atherosclerosis or restenosis using microtubule stabilizing agent  
The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing...
6497904 Treatment of oncologic tumors with an injectable formulation of a golgi apparatus disturbing agent  
Novel pharmaceutical formulations for treating a cellular proliferative disease are provided comprising: a therapeutically effective amount of a Golgi apparatus disturbing agent; a biocompatible...
6495593 Compositions for preventing or treating adverse physiological effects associated with cardiac disease  
A method is disclosed for preventing or treating the adverse physiological effects associated with cardiac disease by administering a purified proanthocyanidin composition to the person in an...
6486202 Inhibitors of isoprenyl transferase  
Provided are novel peptidomimetic isoprenyl transferase inhibitors, methods for synthesizing such inhibitors, and methods for the use of such inhibitors for the treatment of tumors.
6482850 Hydrolysis-promoting hydrophobic taxane derivatives  
Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one...
6469050 7-hexanoyltaxol and methods for preparing the same  
An antitumor compound of formula (5): Also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the...
6469048 α-pyrones for treating α-pyrone responsive states  
Novel α-pyrones are described. The α-pyrones are useful in a method for controlling α-pyrone responsive states in a mammal. The method includes administering to a mammal a therapeutically...
6469058 Chemotherapy of cancer with actyldinaline in combination with gemcitabine capecitabine or cisplatin  
Acetyldinaline in combination with gemcitabine, a pharmaceutically acceptable salt thereof, capecitabine, or cisplatin is synergistic for treating cancer.
6461603 Water-soluble polymer conjugates of artelinic acid  
The present invention provides water-soluble polymer conjugates of the anti-malarial drug, artelinic acid, using water soluble and non-peptidic polymer backbones, such as poly(ethylene glycol). The...
6458347 Drug complex  
Disclosed is a drug complex of a drug having a hydroxyl group, which is capable of controlling the rate of the release of the drug therefrom in blood, the drug complex being represented by the...
6455575 Phosphonooxymethyl ethers of taxane derivatives  
The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
6451340 Nucleotide analog compositions  
The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale...
6444709 Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same  
The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or...
6444230 Synergistic composition of peracetic acid and amine oxide  
Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid,...
6444638 Combinations of PKC inhibitors and therapeutic agents for treating cancers  
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
6441026 Antitumor compositions containing taxane derivatives  
A pharmaceutical composition comprised of acetocyclopropyl taxotere or a derivatve thereof, and at least one of an alkylating agent, an antimetabolite, a spindle poison, an epidophyllotoxin, an...
6428983 Histone deacetylase as target for antiprotozoal agents  
Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
6414014 Method for administration of taxol  
Taxol dosages of about 135 mg/m 2 or greater are administered via infusions of less than 6 hours duration; the method makes it possible to provide taxol infusions on an out-patient basis to...
6403634 Use of taxoid derivatives  
The present invention relates to a new pharmaceutical form of taxoid derivatives, and more particularly to the oral administration of a taxoid bearing two alkoxy groups in position 7 and 10.
Matches 151 - 200 out of 454 < 1 2 3 4 5 6 7 8 9 10 >