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7638553 |
Hydroxamates, their manufacture and use as pharmaceutical agents
Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
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7625944 |
Inhibitors of plasma kallikrein
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
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7605164 |
Compositions and methods for treating heart failure
Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including...
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7592467 |
Inhibitors of prolyl endopeptidase
The present invention relates to novel inhibitors of prolyl endopeptidase of formula (1)
wherein I, A, X, Y and Z are specified in the description. The compounds are useful for the treatment of...
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7592366 |
Therapeutic compounds
A compound having a formula
is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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7572826 |
Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme IKK-2
The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their...
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7569600 |
Compounds and methods for the treatment of prevention of Flavivirus infections
Compounds represented by formula I:
or pharmaceutically acceptable salts and solvates thereof, wherein R 1 , X, Y, Y 1 , and Z are as defined herein, are useful for treating flaviviridae...
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7553868 |
Thiophene carboxamides as inhibitors of the enzyme IKK-2
The invention relates to thiophene carboxamides of formula (I) wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , m and n are as defined in the specification, processes and intermediates used in their...
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7544710 |
Use of the distrontium salt of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethyl-thiophene-5-carboxylic acid for the production of medicaments for the treatment of gastro-duodenal pain
The present invention relates to the use of the distrontium salt of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethyl-thiop
hene-5-carboxylic acid in obtaining medicaments intended for the...
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7528274 |
Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and...
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7521473 |
Inhibitors of protein tyrosine phosphatase 1B
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for...
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7501451 |
Mono-acylated o-phenylendiamines derivatives
Mono-acylated o-phenylendiamines derivatives of formula A:
which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
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7485752 |
Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7462631 |
Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof
The invention discloses and claims a compound of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 11 are as defined herein. Further embodiments of the invention...
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7439372 |
Therapeutic compounds
A compound having a structure
is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
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7429576 |
Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded...
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7423061 |
Substitute thiophenes and uses thereof
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
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7378448 |
Diphenylether amide derivatives as opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
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7365070 |
Modulators of melanocortin receptor
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic...
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7332516 |
Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
The present invention encompasses compounds of Formula I (I)
or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a...
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7332518 |
Carboxamides as fungicides in agriculture
The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R 1 is CH 2 R 2 , CH 2 CH═CHR 2 , CH═C═CHR 2 or...
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7317034 |
Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds
Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in...
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7291647 |
Guanylhydrazone compounds, compositions, methods of making and using
The present invention relates to compounds having the formula:
salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of...
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7244763 |
Compounds that modulate PPAR activity and methods of preparation
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
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7173060 |
Oxime derivatives and their use as pharmaceutically active agents
The present invention relates to compounds of formula I,
their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the...
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7169768 |
Method of decreasing atherosclerosis and its complications
A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
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7166590 |
Amino acid derivatives
A compound of the formula (I):
[wherein R 1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO 2 ; R 2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO,...
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7160910 |
Anti-sickling agents
The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non-toxic, and...
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7125908 |
Treating pain using selective antagonists of persistent sodium current
The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least...
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7115654 |
Caspase-1 inhibitors and methods for their use
The invention provides compounds of Formula I and derivatives thereof, pharmaceutical compositions comprising a compound of Formula I, and methods of treatment utilizing such compounds and...
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7098241 |
Thiophene hydroxamic acid derivatives
The (R) and (S) enantiomers of a compound of formula I
are novel antiproliferative therapeutic agents. These compounds have HDAC inhibitor activity and are useful in the treatment of cancer....
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7067542 |
Diaminediols for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7060723 |
Treating neurological disorders using selective antagonists of persistent sodium current
The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has...
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7053109 |
Aminediols for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7053094 |
Compositions and methods for treating heart failure
Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including...
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7034053 |
Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
The present invention disclosed compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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RE39049 |
Methods for inhibiting bone loss
The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse...
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6992047 |
Method of microencapsulating an agricultural active having a high melting point and uses for such materials
A method of producing a controlled release form of an agricultural active material includes the provision of an organic liquid composition in which the active is present, but where the liquid...
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6982279 |
Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
Compounds of the formulae IA and Ib.
in which X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel...
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6960594 |
Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer
A novel compound which inhibits certain integrins, particularly α v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering...
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6953812 |
Glucagon antagonists/inverse agonists
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
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6933317 |
PGD2 receptor antagonistic pharmaceutical compositions
Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGD 2 receptor:
wherein Y is bicyclic ring; R 1 is optionally substituted...
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6887903 |
N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them
The compounds of formula 1
wherein R and R 2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear...
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6878743 |
Small molecule inhibitors of caspases
The present invention provides compounds having formula (I):
and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R 1 are as described generally and in...
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6878706 |
Cyanamides useful as reversible inhibitors of cysteine proteases
Compounds according to the following formula (I):
wherein the variables Q and R 1 to R 6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F,...
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