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7625914 |
Compounds that modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel compounds having the general formula (I) below:
are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular...
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7576117 |
Cyclic amine CCR3 antagonist
A medicine containing, as an active ingredient, a cyclic amine derivative represented by the following formula (I),
a pharmaceutically acceptable acid addition salt thereof or a...
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7572826 |
Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme IKK-2
The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their...
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7569600 |
Compounds and methods for the treatment of prevention of Flavivirus infections
Compounds represented by formula I:
or pharmaceutically acceptable salts and solvates thereof, wherein R 1 , X, Y, Y 1 , and Z are as defined herein, are useful for treating flaviviridae...
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7553868 |
Thiophene carboxamides as inhibitors of the enzyme IKK-2
The invention relates to thiophene carboxamides of formula (I) wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , m and n are as defined in the specification, processes and intermediates used in their...
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7544710 |
Use of the distrontium salt of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethyl-thiophene-5-carboxylic acid for the production of medicaments for the treatment of gastro-duodenal pain
The present invention relates to the use of the distrontium salt of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethyl-thiop
hene-5-carboxylic acid in obtaining medicaments intended for the...
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7541379 |
Di(amido-substituted)heteroarene compounds as osteoblastogenesis agents
The present invention relates to di(amido-substituted)-heteroarene compounds and their use as osteoblastogenesis agents. The invention provides a method for inducing osteogenesis in a precursor...
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7423061 |
Substitute thiophenes and uses thereof
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
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7417057 |
Pesticidal heterocycles
It has now been found that certain novel heterocyclic derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of...
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7402608 |
Compounds and methods for the treatment or prevention of Flavivirus infections
Compounds represented by formula:
wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a...
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7393868 |
AMPA receptor potentiators
The present invention relates to AMPA receptor potentiators of Formula I:
formulations comprising them, methods for their use, and intermediates useful for their preparation.
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7388012 |
(Hydrazido)(amino)thiophene compounds
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as...
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7326729 |
CXCR1 and CXCR2 chemokine antagonists
The present invention is directed to a compound having the general structure of formula (1):
useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease.
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7247317 |
Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable...
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7196114 |
Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use
Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their use The invention relates to compounds of the formula I
where the radicals are as defined, and their...
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7176201 |
Modulation of anxiety through blockade of anandamide hydrolysis
Fatty acid amide hydrolase inhibitors of the Formula:
are provided wherein X is NH, CH 2 , O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of...
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7166639 |
NF-κB inhibitors
The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7098240 |
Compounds
The invention relates to thiophene carboxamides of formula (I), wherein R 1 , R 2 , R 3 , A, n and X are as defined in the specification, processes and intermediates used in their preparation,...
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7019027 |
2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
The present invention relates to a compound of formula (I):
wherein:
R 3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and R 4 and R 5 taken...
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7019024 |
Pharmaceutical for treatment of neurological and neuropsychiatric disorders
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
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6962929 |
Pentafluorobenzenesulfonamides and analogs
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
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6821960 |
Glucagon antagonists/inverse agonists
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
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6706715 |
Urea derivatives with antiproteolytic activity
The present invention relates to compounds of the formula I, in which R 1 , R 2 , R 4 , R 5 , D 1 , D 2 , X 1 , X 2 , X 3 , A and B have the meanings indicated in the claims. The compounds of...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6677341 |
(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6653321 |
Naphthylsulfonic acids and related compounds as glucose uptake agonists
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
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6586433 |
Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6583179 |
Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders...
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6569895 |
Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of...
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6541475 |
α, β-unsaturated sulfones for treating proliferative disorders
α, β-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents:
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6525099 |
N-substituted sulfonamide derivatives
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
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6509369 |
Anti-inflammatory compounds
This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having the following structure:
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6479528 |
Methods for inhibiting or reversing tau filament formation polymerization
Methods for inhibiting and/or reversing tau filament formation or polymerization are provided. These methods can be used for treating certain neurological disorders in vivo by administering...
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6414013 |
Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
Compounds which are 3-aminocarbonyl-2-carboxamido-thiophene derivatives of formula (I): wherein R 1 and R 2 are, independently from each other, hydrogen, halogen or an optionally substituted...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6344476 |
Inhibition of p38 kinase activity by aryl ureas
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical...
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6342511 |
Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as...
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6340700 |
2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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6333346 |
Ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H)-thiophenones as antitumor agents
The present invention relates to ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H0-thiophenones for the treatment of tumors.
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6329373 |
Metalloproteinase inhibitors
A compound of formula (I) ##STR1## wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation...
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6316467 |
Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6291514 |
Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
The present invention is directed to compounds of Formula I: ##STR1## wherein X is O, S or NR 7 and R 1 -R 7 , Y and Z are set forth in the specification, as well as hydrates, solvates or...
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6274590 |
Method of treating skin related conditions
A class of 3,4-diaryl substituted thiophene, derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related...
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6239166 |
Compositions for killing dust mites and methods of using same
The invention relates to an aqueous pesticide composition for killing dust mites, which contains a chelating agent as the active ingredient and a surfactant to facilitate distribution over, or...
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6197795 |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-α...
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6180095 |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L 1 is a bifunctional...
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