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Document Title |
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7524859 |
(2-carboxamido)(3-amino)thiophene compounds
A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by
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7476691 |
Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors
The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R 1 , R 2 , R 3 , m and n are as defined in the specification. The invention also relates to...
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7332492 |
Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
Compounds of formula (I):
wherein:
X is a group of formula (B):
and R 1 , R 2 , R 4 , n, x, y and z are as defined within are described.
Processes for their preparation and...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7101893 |
(2-Carboxamido)(3-amino)thiophene compounds
A method of treatment of hyperproliferative disorders comprises administering an effective amount of a compound represented by Formula II:
or a pharmaceutically acceptable salt thereof.
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6992101 |
N-(indole-2-carbonyl) and H-thieno[2,3-b]pyrrole-5-carboxamide anti-diabetic agents
The present invention provides compounds of formula (I)
the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein R′, R″, R′″, and Z are as...
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6949563 |
(2-carboxamido)(3-amino)thiophene compounds
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is
R2 is
and R3 is C 0-4 alkyl, are useful in the treatment of cancer.
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6875790 |
Cyclic sulfone containing retroviral protease inhibitors
The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV...
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6747057 |
Compounds and their therapeutic use
Compounds of formula I: [wherein: X represents —CH═CH—, —CH═CR—, —CR═CR—, —CO—, —O—, —NH—, —NR—, S—, —SO—, —SO 2 —, —CH═N—, —CR═N—,...
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6569895 |
Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of...
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6541475 |
α, β-unsaturated sulfones for treating proliferative disorders
α, β-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents:
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6395769 |
2-arylbenzo&lsqb b&rsqb thiophenes useful for the treatment of estrogen deprivation syndrome
This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia...
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6277874 |
Methods for the treatment of apolipoprotein E related diseases
Methods for treating diseases associated with toxicity of Apolipoprotein E ("apoE"). Specifically, the present invention relates to new methods for treating a mammal having a condition associated...
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6162815 |
RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are...
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6096781 |
2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome
This invention provides methods which are useful for the inhibition of the various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia...
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5972950 |
1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
The present invention relates to the derivatives of formula: ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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5872121 |
Pesticidal hydrazide derivatives
A compound of the formula ##STR1## wherein R is a) phenyl; phenyl(C 1 -C 4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of...
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5580893 |
Nitroxyalkylamide derivatives
Nitroxyalkylamide compounds having the formula: R 1 --(A) n --CONH--B'--ONO 2 wherein R 1 is an optionally substituted furyl, furyloxy, thienyl, thienyloxy, isoxazolyl, phenoxy, phenylthio or...
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5541219 |
1-Alkoxy-2-(alkoxy- or cycloalkoxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-) benzenes as inhibitors of cyclic AMP phosphodiesterase and tumor necrosis factor
This invention is directed to 1-alkoxy-2-(alkoxy- or cycloalkyloxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-)benzene compounds that inhibit cyclic AMP phosphodiesterase or tumor necrosis factor...
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5519033 |
Azabicyclo derivatives for treatment of urinary incontinence
The present invention relates to a method of treating urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives of...
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5418230 |
Benzylidene derivatives
Benzylidene derivatives having anti-inflammatory activities, are shown by the following formula I: ##STR1## wherein A is -CH 2 - or -CH 2 CH 2 -; B is a bond or -CH 2 -, -CHOH-, -CO-, -O-, or A...
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5403857 |
Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory activity
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R 1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R 2 and R 3 together form -A 2 -X 2 -A 3 - which...
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5270301 |
Fluoro-amide derivatives
The present invention relates to certain fluoro-amide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired,...
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4990505 |
Phenethanolamine compounds
The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The...
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4933369 |
Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones
The present invention relates to new compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof and the enantiomers thereof, wherein R 1 is H, lower alkyl, alkenyl,...
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4880828 |
2-(tetrahydro-2-thienyl)phenyl esters of phosphorothioic acid
A new class of 2-(tetrahydro-2-theinyl)phenyl esters of phosphorothioic acid is disclosed. This class of compounds is an effective pesticide and finds particular application as an insecticide. A...
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4861766 |
Antimicrobial composition
An antimicrobial composition containing, as a mixture of active ingredients, (A) at least one complex of the formula ##STR1## wherein R 1 is a hydrogen atom or a substituted or unsubstituted...
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4859698 |
Novel class of acyl-derivatives of carnitine, process for preparing same and therapeutic use thereof
A novel class of acyl-derivatives of carnitine is disclosed wherein the acyl radical is either the radical of unsaturated organic acids (typically, acrylic acid) or the radical of saturated organic...
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4546110 |
Pheromones
Compounds which are β-farnesene derivatives obtainable as a Diels-Adler adduct of β-farnesene and a dienophile or by a modification of such an adduct in a manner as defined herein are of value in...
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4482568 |
Inhibition of alcohol metabolism by tetramethylene sulfoxides
Tetramethylene sulfoxide and its substituted derivatives have been found to be exceptionally potent inhibitors of oxidation of alcohols by liver alcohol dehydrogenases.
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4438130 |
Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula ##STR1## wherein p, n, m, A, E, R, R 1 , R 2 , X, Y and Z are as defined in the specification, e.g.,...
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4282246 |
Antidiabetic furancarboxylic and thiphenecarboxylic acids
Compounds of the structure ##STR1## wherein Z is oxygen or sulfur; R is (C 1 -C 2 )alkoxy; phenoxy; benzyl; phenylthiomethyl; phenylthio; phenylthio monosubstituted in the 2-, 3-...
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4211783 |
Hypolipidemic and antiatherosclerotic novel 4-(aralkyl- and heteroarylalkylamino)phenyl compounds
This disclosure describes novel 4-(aralkyl- and heteroarylalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
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4070479 |
1-Tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas as antihypertensive agents
This invention relates to a class of 1-tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas that exhibit antihypertensive activity in warm-blooded animals....
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3928198 |
Synergistic compositions containing 2,2-dibromo-3-nitrilopropionamide and 3,3,4,4-tetrachlorotetrahydrothiopene-1,1-dioxide and their use
The present invention relates to certain processes and compositions useful for inhibiting the growth of slime in water and, in particular, water used for industrial purposes; for example, in the...
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3879536 |
Control of bacteria and fungi in aqueous systems
A composition consisting essentially of 3,3,4,4-tetrachlorotetrahydrothiophene-1,1-dioxide and bis(trichloromethyl)sulfone exhibits a synergistic effect in the inhibition of growth of...
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3862323 |
DIOXIDE SLIME CONTROL COMPOSITION AND ITS USE
The present invention relates to certain processes and compositions useful for inhibiting and/or controlling the growth of slime in water and, in particular, water employed for industrial purposes....
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3806598 |
METHOD OF CONTROLLING GASTROPODS
Gastropods, including the vectors of parasitic flukes that afflict man and animals, are controlled by exposing such gastropods or their eggs to an amount of a polychlorothiopheneoxide sufficient to...
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3764689 |
2,2,3,4,5,5-HEXACHLORO-2,5-DIHYDROTHIOPHENE 1,1 DIOXIDE USED TO CONTROL BACTERIA AND FUNGI
The compound 2,2,3,4,5,5-hexachloro 2,5-dihydrothiophene-1,1 dioxide used to control bacteria and fungi.
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3073691 |
Method of killing microorganisms, plant pests, and plants with halogenated thiophene-1, 1-dioxide compounds
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3073692 |
Method of killing microorganisms, plant pests, and plants with halogenated dihydrothiophene-1, 1-di-oxide compounds
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3044865 |
Method of controlling plant growth by the application of 3-halo-2, 3-dihydrothiophene-1, 1-dioxide
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2987437 |
Nematocidal composition
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2937972 |
Method of controlling nematode infestation
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2928766 |
Method of killing nematodes by treatment with 3-halo-2, 3-dihydrothiophene-1, 1-dioxide
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3629437 |
Title is not available
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3821396 |
Title is not available
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3822351 |
Title is not available
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3824316 |
Title is not available
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