|
Match
|
Document |
Document Title |
|
|
7592467 |
Inhibitors of prolyl endopeptidase
The present invention relates to novel inhibitors of prolyl endopeptidase of formula (1)
wherein I, A, X, Y and Z are specified in the description. The compounds are useful for the treatment of...
|
|
|
7592337 |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
|
|
|
7589120 |
N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application
The invention relates to compounds of formula (I):
Wherein X, R 1 , R 2 , R 3 and R 4 are as described herein. The invention also relates to a method for preparing the aforementioned...
|
|
|
7589111 |
C10 cyclopentyl ester substituted taxanes
A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3′ and an isopropoxycarbamate substituent at C3′.
|
|
|
7585865 |
Protein kinase C zeta inhibition to treat vascular permeability
Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of...
|
|
|
7579340 |
Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
|
|
|
7569600 |
Compounds and methods for the treatment of prevention of Flavivirus infections
Compounds represented by formula I:
or pharmaceutically acceptable salts and solvates thereof, wherein R 1 , X, Y, Y 1 , and Z are as defined herein, are useful for treating flaviviridae...
|
|
|
7524869 |
Taxanes having a C10 ester substituent
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
|
|
|
7524863 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
|
|
|
7521473 |
Inhibitors of protein tyrosine phosphatase 1B
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for...
|
|
|
7507761 |
Benzopyran derivatives, method of production and use thereof
The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof.
wherein:
R 1 , R 2 , R 3 and R 4...
|
|
|
7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
|
|
|
7495023 |
Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use
The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as...
|
|
|
7482376 |
Conjugated complement cascade inhibitors
The present invention is directed to conjugated complement cascade inhibitors, and a method of treating a patient using a conjugated complement cascade inhibitor.
|
|
|
7465718 |
Ansamycins having improved pharmacological and biological properties
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and...
|
|
|
7462631 |
Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof
The invention discloses and claims a compound of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 11 are as defined herein. Further embodiments of the invention...
|
|
|
7435750 |
Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I:
wherein Ar 1 , Ar 3 , A, B and D are defined herein. The...
|
|
|
7423060 |
Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors
Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned...
|
|
|
7410999 |
Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure...
|
|
|
7402608 |
Compounds and methods for the treatment or prevention of Flavivirus infections
Compounds represented by formula:
wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a...
|
|
|
7393846 |
Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs,...
|
|
|
7388012 |
(Hydrazido)(amino)thiophene compounds
Compounds represented by Formula (I):
or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as...
|
|
|
7368477 |
Benzofuranyl alkanamine derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 1′ , R 2 , R 3 , R 4 , n, and Ar are as defined, and described in classes and...
|
|
|
7365089 |
Triazolo-quinolin derivatives useful as adenosine receptor ligands
The present invention relates to adenosine A 3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the...
|
|
|
7354940 |
2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12
The invention provides compounds of formula (I) in which L, X, Y, Z 1 , Z 2 , R 1 , R 2 , R 3 and G 2 have the meanings defined in the specification; processes for their preparation;...
|
|
|
7354936 |
2-phenylpyran-4-one derivatives
The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula
processes for their preparation, pharmaceutical compositions containing them, and their medical...
|
|
|
7332492 |
Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor
Compounds of formula (I):
wherein:
X is a group of formula (B):
and R 1 , R 2 , R 4 , n, x, y and z are as defined within are described.
Processes for their preparation and...
|
|
|
7326729 |
CXCR1 and CXCR2 chemokine antagonists
The present invention is directed to a compound having the general structure of formula (1):
useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease.
|
|
|
7319111 |
Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
|
|
|
7288538 |
Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
|
|
|
7282518 |
Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
|
|
|
7256213 |
Taxanes having a C10 carbonate substituent
Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.
|
|
|
7226944 |
Taxanes having a C7 carbonate substituent
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
|
|
|
7223780 |
Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions...
|
|
|
7220734 |
1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists
The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
|
|
|
7211570 |
Treatment of EBV and KHSV infection
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
|
|
|
RE39575 |
Substituted thioacetamides
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
|
|
|
7199148 |
Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
The present invention concerns the compounds having the formula
N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
|
|
|
7196106 |
Cyanothiophene derivatives, compositions containing such compounds and methods of use
The present invention addresses substituted cyanothiophene derivatives of the formula I:
as well as compositions containing such compounds and methods of treatment. The compounds in the present...
|
|
|
7192978 |
Pyrrolidinium derivatives
New pyrrolidinium derivatives having the chemical structure of general formula (I)
are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and...
|
|
|
7189758 |
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
A compound of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
|
|
|
7186752 |
Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
|
|
|
7167678 |
Persistent peer-to-peer networking over a piconet network
A persistent peer-to-peer network is implemented over a network with master-slave topology. Data being sent from master to slave or from slave to master are sent in one transmission, but data sent...
|
|
|
7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
|
|
|
7160872 |
Methods to treat conditions mediated by chemokine receptors
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
|
|
|
7157474 |
C10 heterosubstituted acetate taxane compositions
Compositions comprising a taxane having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
|
|
|
7153884 |
C-2′ methylated derivatives of paclitaxel for use as antitumour agents
Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R 1 is t-butoxycarbonyl or benzoyl; R 2 is hydroxy; R 3 is hydrogen or, together with R 2 , it forms...
|
|
|
7153869 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
|
|
|
7148218 |
Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain substituted polyketides of formula I,
wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of...
|
|
|
7144902 |
Prodrugs of thrombin inhibitors
The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like...
|