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7612107 |
Treatment and inhibition of disease conditions using flexible heteroarotinoids
The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions...
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7598417 |
Substituted fluoroethyl ureas as alpha 2 adrenergic agents
The present patent application is directed to novel fluoroethyl urea compounds and compositions and their therapeutic use in the treatment of pain and other conditions.
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7589232 |
Alkynyl aryl carboxamides
The present invention is related to alkynyl aryl carboxamides of Formula (I′) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders...
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7589089 |
Inhibitors for GlyT-1
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , R 3 , R 4 , and X are as defined herein or to pharmaceutically acceptable acid addition salts thereof, with the...
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7585888 |
Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
This invention relates to novel benzofuran and benzothiophene derivatives of the general formula
and their use for the treatment of hyper-proliferative disorders.
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7582673 |
Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use
Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are...
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7576122 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular...
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7550461 |
Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases
Disclosed are amide compounds of formula (I):
wherein Ar 1 , Q, Y and R 3 -R 6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory...
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7547722 |
Chemical compounds
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
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7534791 |
Benzo[b]furane and benzo[b]thiophene derivatives
The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.
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7524866 |
Prevention and treatment of androgen—deprivation induced osteoporosis
This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate...
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7511046 |
Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7473704 |
Cyclohexyl prostaglandin analogs as EP4-receptor agonists
The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP 4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in...
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7465825 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7465752 |
Pentenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
Compounds of the formula (I):
in which R, R 1 , R 2 and R 3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to...
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7462629 |
Immunosuppressant compounds and compositions
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
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7449490 |
Pharmaceutically active compounds and methods of use
New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of...
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7449483 |
Heteroaromate OSC inhibitors
The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol...
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7442808 |
Antidiabetic bicyclic compounds
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof,...
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7439271 |
Reduction of hair growth
Mammalian hair growth is reduced by applying an inhibitor of telomerase to the skin.
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7435834 |
2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as...
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7432296 |
Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds
Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds corresponding to formula I, as well as to their use...
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7429670 |
Synthesis of derivatives of ginkgolide C
The subject invention provides ginkgolide C derivatives compounds having the structure:
wherein R is H or -A-Ar,
where A is an alkyl group; and Ar is an aryl group, which may contain...
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7417065 |
Immunosuppressant compounds and compositions
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
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7417064 |
3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake
There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C 2 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 cycloalkyl and C 4 -C 8 ...
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7410996 |
3-aryloxy/thio-2,3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake
There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected...
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7402607 |
DNA-PK inhibitors
A compound of formula I:
and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein:
R 1 and R 2 are independently selected from hydrogen, an optionally...
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7399781 |
N-substituted benzothiophenesulfonamide derivatives
The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for...
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7384974 |
4,5-dihydronaphtho[1,2-b]thiophene derivative
A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula:
(wherein R 1 is a C 1 to C 10 1-hydroxyalkyl group or a C 1 to C 10 acyl group, and R 2 and R 3 separately...
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7384947 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula
and its use for the treatment of hyper-proliferative disorders.
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7381734 |
Serine protease inhibitors
Compounds of formula (I)
where R 5 , R 6a , each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
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7375130 |
Antidiabetic compounds comprising benzofuran and benzothiophene derivatives
The invention relates to compounds of the general formula (I) below:
in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1.
These compounds can be used in the treatment of...
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7371774 |
Benzofurans and benzothiophenes
The invention relates to compounds of the general formula (I) below:
in which R1, R2, R3, R4, R5, R6 and X are as defined in claim 1.
These compounds can be used in the treatment of...
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7351735 |
Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
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7342043 |
Medicinal compositions improving brain function and method for improving brain function
An alkyl ether derivative represented by the formula:
wherein R 1 , R 2 , R 3 , R 4 , m and n are as defined in the specification, or salts thereof exhibits synergistically improved...
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7323494 |
Compounds and methods
Disclosed is a compound of having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables...
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7312239 |
Medicament for prevention and/or therapy of arterial wall disorder
An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided...
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7288560 |
Spirocyclic cyclohexane derivatives
The present invention relates to spirocyclic cyclohexane compounds, to methods for their production, to pharmaceutical compositions containing these compounds, to methods of treatment using such...
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7279494 |
Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I
or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents,...
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7276518 |
Substituted cyclohexane-1,4-diamine compounds
Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds.
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7273876 |
Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use
The present invention addresses substituted thiophene derivatives, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon...
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7268158 |
6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
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7268148 |
Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen...
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7265130 |
NPY Y5 antagonist
The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I):
wherein R 1 is lower alkyl, cycloalkyl or the...
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7253165 |
Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical...
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7244763 |
Compounds that modulate PPAR activity and methods of preparation
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
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7217723 |
Heterocyclic compound having oxime group
The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to...
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