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7452914 |
Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more...
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7449451 |
Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
Disclosed herein is a method for protecting humans in need of such protection from physical damage caused by ionizing radiation comprising administering to said humans on a defined basis prior to...
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7429614 |
Medicament containing an effector of the glutathione metabolism together with α-lipoic acid for treating diabetes mellitus
The invention relates to a medicament containing an effector of the glutathione metabolism together with α-lipoic acid for treating diabetes mellitus. This medicament enables disturbances of the...
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7399755 |
Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same
The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7326690 |
Modulation of cell fates and activities by phthalazinediones
Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox...
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7304089 |
Preparation for improved dietary utilisation
Food, feed or drug preparations are described that contain conjugated trans/cis-octadecatrienoic acid, and processes are described for their production. Inventive preparations preferably comprise...
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7235582 |
Basic salt of thioctic acid with L-carnitine
Salt of thioctic acid with L-carnitine with the formula:
AY(X) x
where A is
...
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7202270 |
Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses
A process for the manufacture of new crystalline salts of N-[2-(dimethylamino)ethyl]-1,2-dithiolane-3-pentanamide (racemic and chiral forms) is described. Such salts are stable, crystalline and...
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7196065 |
Enteral formulation
A formulation for enteral administration to a patient is disclosed.
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7125882 |
Treatment of acne using alkonolamine compositions
Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or...
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7081479 |
Treatment of acne using alkonolamine compositions
Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or...
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7078402 |
Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof
The invention relates to novel aminothiol ester compounds having the general formula (I):
and to a method for preparing them and to their use in pharmaceutical compositions intended for use in...
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7030154 |
Stability of lipoic acid
A method of stabilizing R-α-lipoic acid includes combining R-α-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress...
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6998419 |
3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1...
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6964969 |
Composition and method for treating impaired or deteriorating neurological function
A nutritional supplement composition for normalizing impaired or deteriorating neurological function in humans is composed of: at least one agent which promotes synthesis of ATP and/or creatine...
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6951887 |
Lipoic acid derivatives and their use in treatment of disease
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions...
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6939860 |
Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds
The present invention relates to a composition comprising a catechin compound, ascorbic acid, proline and lysine. The present invention also relates to a method for treating neoplastic disease...
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6923960 |
Antioxidant combination composition and use thereof
An orally or parenterally administrable composition which comprises the following components:
(a) L-carnitine inner salt or a pharmacologically acceptable salt thereof; (b) acetyl L-carnitine...
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6914071 |
Antioxidant containing composition and method
A companion pet diet meeting ordinary nutritional requirements of the pet and further comprising a sufficient amount of an antioxidant or mixture thereof to inhibit the onset of deterioration of...
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6908941 |
Hair and nail treatments using alkanolamines
Topical application of compositions containing an alkanolamine such as dimethylaminoethanol increase smoothness and surface uniformity of hair and nails and enhances hair and nail growth....
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6897211 |
Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and...
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6887894 |
Use of lipoic acid for improving the bioavailability of mineral salts
The use of α-lipoic acid or α-dihydrolipoic acid for increasing the bioavailability of mineral salts, the use of α-lipoic acid or α-dihydrolipoic acid in combination with metal salts, in...
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6863904 |
Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects
The present invention relates to compositions without added iron and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method...
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6750209 |
Advanced glycation end-product intermediaries and post-amadori inhibition
The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation,...
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6743433 |
Treatment of acne using alkanolamine compositions
Acne is treated or prevented by the topical application of compositions containing an alkanolamine such as dimethylaminoethanol, tyrosine, and a sulfur ingredient such as lipoic acid or...
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6733793 |
Oral composition with insulin-like activities and methods of use
An orally administered, novel dietary supplement or therapeutic composition capable of insulin-like activity in animals, preferably humans, is provided. Contained in the composition are...
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6730700 |
3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1 -R 4...
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6649639 |
Antipicornaviral compounds, compositions containing them, and methods for their use
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical...
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6624154 |
Compositions and methods for treatment of hyperproliferative diseases
The invention relates to compositions comprising a retinoid X receptor agonist and an agent capable of activating protein kinase A. The invention also relates to methods of treating...
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6620425 |
Food supplements and methods comprising lipoic acid and creatine
Food supplement compositions comprise lipoic acid or a derivative thereof and creatine or a derivative thereof. The compositions optionally, but preferably, further comprise dextrose. The food...
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6605637 |
Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration...
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6586472 |
Treatment of rosacea using lipoic acid
Rosacea is treated by application of a composition containing lipoic acid and/or a lipoic acid derivative such as dihydrolipoic acid, a lipoic or dihydrolipoic acid ester, a lipoic or dihydrolipoic...
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6573299 |
Method and compositions for treatment of the aging eye
This invention relates to a method for the prevention and treatment of orbital disorders associated with the aging eye in mammals by the application of a topical composition comprising a permeation...
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6545039 |
Facilitated administration of α-lipoic acid or derivatives thereof
Racemic α-lipoic acid or its enantiomers or pharmaceutically acceptable salts, esters or amides thereof can be administrated parenterally at a rate of 50 to 600 mg of active compound, based on...
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6518300 |
Treatment of lipid metabolic disorders using 5-(1,2-dithiolan-3-yl) valeric acid (α-lipoic acid) or its physiologically compatible salts
Lipid metabolic disorders, such as hyperlipidemia or hyperlipoproteinemia can be treated by administering to an afflicted individual an effective amount of 5-(1,2-dithiolan-3-yl) valeric acid...
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6500857 |
Subcutaneous muscle treatment using electronic stimulation and topical compositions
Aging and sagging subcutaneous muscles are treated by first applying a composition containing at least one acetylcholine precursor and/or at least one compound exhibiting catecholamine activity to...
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6469049 |
Method of treating, preventing or inhibiting central nervous system injuries and diseases
Methods of preventing, treating, or both preventing and treating CNS injury, disease, neurotoxicity or memory deficit in a subject by the administration of at least one lipoic acid compound to the...
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6448287 |
Treatment of cancer using lipoic acid in combination with ascorbic acid
Lipoic acid and/or its water soluble salt is used to treat cancer, alone or in combination with ascorbic acid (vitamin C). Alone or in combination, it was shown to be effective on in vitro tumors...
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6441024 |
Crystal modification of lipoic acid
In the 2 Θ diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 Θ=23°.
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6432434 |
Treatment of and/or prophylaxis against brain and spinal cord injury
The administration of α-lipoic acid (αLA) and dihydrolipoic acid (DHL) both as a preventive measure before exposure to conditions which may cause damage, such as rapid changes in atmospheric...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6403553 |
Use of polypeptides for treating thrombocytopenia
The present invention relates to the use of polypeptides of the MIP (macrophage inflammatory proteins) class for the treatment of diseases involving a pathological change of thrombocytopolesis,...
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6387945 |
Lipoic acid analogs
A compound is provided having the formula I: wherein the variables are defined in the specification. Methods of making the compounds, compositions including the compounds and methods of...
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6369098 |
Dithiolane derivatives
The present invention describes methods for synthesizing novel dithiolane derivatives, ligands with high affinity for the nuclear hormone receptors, peroxisome proliferator-activated receptor-γ...
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6365622 |
Antioxidant composition comprising acetyl L-carnitine and α-lipoic acid
A composition containing the active ingredients acetyl L-carnitine and α-lipoic acid for the prevention and/or therapeutic treatment of various alterations and pathological states induced by free...
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6348490 |
Dosage forms containing thioctic acid or solid salts of thioctic acid with improved release and bioavailability
Novel, advantageous dosage forms of thioctic acid and the enantiomers thereof together with thioctic acid salts are described. The pharmaceutical formulations according to the invention are used...
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6342517 |
Potassium channel activators and their use
Novel thienopyran compounds are disclosed, useful as anti-hypertensive agents and for asthma treatment. One group of the compounds has a heterocyclic ring spiro-connected at the 7-position of the...
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6335361 |
Method of treating benign forgetfulness
Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the...
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6319942 |
Topical scar treatments using alkanolamines
Cutaneous scars are reduced by the topical application of compositions containing an alkanolamine such as ethylaminoethanol, methylaminoethanol, dimethylaminoethanol, isopropanolamine,...
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