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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7115258 |
Vesicular monoamine transporter gene therapy in parkinson's disease
The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed....
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7112337 |
Liposome composition for delivery of nucleic acid
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and...
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7112331 |
Vaccines against varicella zoster virus gene 63 product
The present invention relates to compositions for the treatment or prevention of Zoster of individuals infected with Varicella Zoster virus (VZV), and to the prevention and treatment of Varicella...
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7112321 |
Adeno-associated virus-mediated delivery of GDNF to skeletal muscles
Compositions and methods for delivering GDNF to skeletal muscles to result in a therapeutic effect are disclosed. The compositions and methods use adeno-associated virus (AAV)-based gene delivery...
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7109179 |
Methods and compositions comprising DNA damaging agents and p53
The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor suppressor...
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7109178 |
Method for ligating nucleic acids and molecular cloning
The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector...
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7109006 |
Virulence of Streptococci
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for...
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7108844 |
Use of stabilized oligonucleotides for preparing a medicament with antitumor activity
The invention concerns the use of stabilized oligonucleotides comprising at least an octamer motif of the type: 5′-purine-purine-CG-pyrimidine-pyrimidine-X 1 X 2 -3′ wherein the pair X 1 -X 2 -...
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7105496 |
Methods and compositions for inhibiting angiogenesis
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits...
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7105494 |
Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a...
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7105493 |
Methods and compositions for treating flaviviruses and pestiviruses
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
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7105162 |
Pharmaceutical composition for immunomodulation based on peptides and adjuvants
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
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7105156 |
Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56 RB protein, a fragment of the p56 RB...
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7101861 |
Methods and compositions for treating flaviviruses and pestiviruses
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
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7101542 |
Cell-mediated targeting of toxins to pathogenic cells
The invention features vectors encoding immunotoxic fusion proteins containing targeting domains and toxic domains, targeting cells transduced with the vectors, methods of making the targeting...
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7101540 |
Targeted retrograde gene delivery to motor neurons
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene,...
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7098192 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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7098191 |
Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the...
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7098190 |
Formulations comprising antisense nucleotides to connexins
A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site...
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7098030 |
Polyampholytes for delivering polyions to a cell
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7098004 |
Isolated polypeptide of the stratum corneum and its use
The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing...
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7097970 |
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7097854 |
Amino alcohol derivatives, process for their production and pharmaceutical preparations and reagents containing these compounds
The present invention relates to new amino alcohol derivatives, process for the production thereof and medicaments and reagents containing these compounds.
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7094767 |
Polynucleotide herpes virus vaccine
Genes encoding herpes simplex virus type 2 (HSV-2) proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were immunized...
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7094766 |
Use of locally applied DNA fragments
Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or...
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7094765 |
Antisense restenosis composition and method
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a...
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7094408 |
Immunogenicity using a combination of DNA and vaccinia virus vector vaccines
This invention relates to improved methods of inducing an immune response for the prevention or treatment of HIV-1 infection by using a nucleic acid vaccine in conjunction with a recombinant viral...
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7094201 |
System and method for genetically treating cardiac conduction disturbances
The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance...
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7091040 |
P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT)
The invention hereindescribed relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific...
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7090846 |
Method for preparing polycation based bioconjugates suitable for transporting different kinds of active substances within the body
Polycation bioconjugates and a method for producing them. The polycations are capable of transporting active substances of different types. The polycations function as carrier molecules that...
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7090836 |
Vector for expressing α-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal
A purified nucleic acid molecule capable of expressing a lysosomal enzyme, e.g., iduronidase or arylsulphatase, is provided. The molecule includes a promoter of the phosphoglycerate kinase gene to...
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7087586 |
Oligonucleotide compositions and their use to induce differentiation of cells
The present invention provides compositions comprising a 3′-OH, 5′-OH, chemically unmodified, synthetic phosphodiester nucleotide sequence selected from the group consisting of SEQ ID NO: 1,...
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7087585 |
Tripeptide of FcγRIIA
The present invention relates, in general, to phagocytosis and phagolysosomal fusion and, in particular, to a tripeptide of FcγRIIA that mediates trafficking of targets phagocytosed via FcγRIIA...
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7087584 |
Detection and modulation of IAPs and NAIP for the diagnosis and treatment of proliferative disease
Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics...
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7087583 |
Sequence specific DNA binding by p53
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in...
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7087582 |
Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an...
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7087581 |
Method for the treatment of diseases or disorders of the inner ear
In a process for the treatment of diseases or disorders of the inner ear linked with damage or destruction of sensory cells of the inner ear, for regenerating the sensory cells use is made of at...
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7087580 |
Neuropilin antisense oligonucleotide sequences and methods of using same to modulate cell growth
This invention relates to oligonucleotides complementary to the neuropilin genes which modulate tumor cell growth and angiogenesis in mammals. This invention is also related to methods of using...
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7087433 |
7SK RNA regulated transcription
A method for altering transcription in a cell comprising an amount of active CDK9/cyclin, comprises the steps of: (a) introducing in the cell an agent which modulates the amount of active...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7084125 |
Xylo-LNA analogues
Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more...
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7081509 |
Method for producing highly functional, hyper branched polyester by means of enzymatic esterification
The present invention relates to a process for preparing highly functional hyperbranched polyesters which comprises reacting a reaction solution comprising solvent and
(a) one or more dicarboxylic...
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7078416 |
Polypeptides
The present invention relates to polypeptides, and nucleic acids DNA encoding these polypeptides, capable of eliciting an immune reaction against cancer, methods for generating T lymphocytes...
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7078390 |
Ribozymes to growth factor originating in human platelet
A ribozyme comprising the following nucleotide sequence (SEQ ID NO:14) (I):
3′-GUGCCCCA GUACGGUG-5′ A C A UGA G AGU N 3 N 1 N 2
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7078389 |
Chemically modified oligonucleotide for site-directed mutagenesis
A mutagenic, triplex-forming oligonucleotide and methods for use thereof wherein the oligonucleotide is chemically modified to incorporate a mutagen and forms a triple-stranded nucleic acid...
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7078388 |
DNA vaccines for farm animals, in particular bovines and porcines
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal...
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7078387 |
Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors
This invention relates to the use of recombinant adeno-associated virus (rAAV) vectors to transduce cardiomyocytes in vivo by infusing the rAAV into a coronary artery or coronary sinus. rAAV...
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7078379 |
Treatment of congenital muscular dystrophies
The invention provides a method of treating congenital muscular dystrophy due to a mutation in the LAMA2 gene in a mammal. The method comprises administering to the mammal a therapeutically...
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