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7148203 |
Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell
This invention relates to a system for introducing nucleic acid into the DNA of a cell. The system includes the use of a member of the SB family of transposases (SB) or nucleic acid encoding the...
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7148202 |
Receptor-mediated gene delivery using bacteriophage vectors
Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated...
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7148201 |
Use of human plasma hyaluronidase in cancer treatment
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7148191 |
Antigenic composition
The invention relates to a composition comprising
a T cell epitope or a mixture of T cell epitopes a polycationic peptide and a nucleic acid based on inosin and cytosin and its use as a...
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7148014 |
Methods of inhibiting phagocytosis
The present invention relates, in general, to methods of treating diseases resulting from interactions between immune complexes and Fc receptors. In particular, the present invention relates to...
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7144870 |
Hyaluronic acid mediated adenoviral transduction
The present invention provides methods of treatment of adenoviral mediated disease, improved methods for transducing cells with adenoviral and related vectors, and improved methods of gene therapy...
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7144869 |
Nucleic acid injected into hapatic vein lumen and delivered to primate liver
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in...
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7141552 |
Use of lipid conjugates in the treatment of diseases
The invention provides a method for treating a subject suffering from an intestinal disease, including, inter alia, Crohn's disease, ulcerative colitis, immuno-inflammatory intestinal injury,...
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7141551 |
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
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7141550 |
Intra-tumoral administration of IL-12 encoding nucleic acid molecules
Described is the use of a nucleic acid molecule encoding an IL-12 polypeptide for the preparation of a pharmaceutical composition for the treatment of a tumor, wherein the pharmaceutical...
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7141540 |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said...
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7141425 |
Apparatus and method for electroporation of biological samples
The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a...
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7138384 |
Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
A synthetic oligonucleotide comprising a C-5 methylcytosine and which recognizes and binds an allosteric site on DNA methyltransferase thereby inhibiting DNA methyltransferase activity is...
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7138383 |
Treating cancer using an oligonucleotide N3′->N5′ thiophosphoramidate
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S − )O-5′ linkage, and methods of synthesizing and using the inventive...
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7138382 |
Compositions and methods for drug delivery using pH sensitive molecules
A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery...
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7138381 |
Compositions containing nucleic acids and ligands for therapeutic treatment
Preparations of conjugates of a receptor-binding internalized ligand and a cytocide-encoding agent and compositions containing such preparations are provided. The conjugates contain a polypeptide...
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7138380 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7138379 |
Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons
The present invention is directed towards a method of potentiating the anti-growth effects of type I interferon (IFN) on cells in a target cell population comprising increasing the number of...
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7138378 |
Genetic suppression and replacement
A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of:
1. providing suppressing nucleic...
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7138272 |
Gene transfer in human lymphocytes using retroviral scFv cell targeting
The invention relates to gene transfer into human T cells using novel retroviral scFv cell targeting vectors and using these vectors for the treatment of T-cell-associated diseases.
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7135463 |
RHoB as a suppressor of cancer cell growth, cell transformation, and metastasis
The present invention concerns the use of the protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant cell transformation, and/or to modulate...
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7135303 |
Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding
The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene,...
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7135287 |
Human antibodies
The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening...
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7135177 |
Immunoliposomes that optimize internalization into target cells
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab'...
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7135171 |
Endothelial precursor cells for enhancing and restoring vascular function
The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.
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7132407 |
DNA vaccine containing tumor-associated gene and cytokine gene and method of preparation the same
The present invention discloses a DNA vaccine and the method of preparation preparing the same, which employs DNA recombination technique to co-incorporate a fragment of tumor-associated gene and a...
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7132406 |
Stimulation of cellular regeneration and differentiation in the inner ear
The present invention provides methods for stimulating the formation of inner ear cells, including inner ear sensory hair cells and inner ear support cells. The methods of the present invention...
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7132405 |
Targeting vector to the urokinase plasminogen activator receptor
The present invention relates to the targeted delivery of a delivery vehicle construct which specifically binds to and stimulates endocytosis into cells expressing the urokinase plasminogen...
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7132404 |
Compositions for receptor/liposome mediated transfection and methods of using same
The present invention provides a composition of matter for introducing an exogenous nucleic acid molecule into a target cell, comprising a liposome, a ligand polymeric scaffold, wherein the ligand...
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7129223 |
Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference
The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference...
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7129222 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7128916 |
Bacteriophage-mediated immunisation
The present invention relates to vaccines comprising a bacteriophage which has been engineered to express an immunogenic protein/peptide and wherein the surface of the bacteriophage has not been...
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7125859 |
Nucleic acid antioxidant compositions, methods for obtaining such compositions and formulations thereof
Compositions containing purified nucleic acid wherein the nucleic acid acts as an antioxidant. Such compositions also include materials subject to oxidative damage such as antioxidants, vitamins,...
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7125858 |
Hyaluronic acid in the treatment of cancer
The present invention relates to a composition and method comprising purified HA, a second anti-neoplastic agent and a pharmaceutically acceptable carrier, wherein the purified HA and the second...
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7125857 |
Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
A synthetic oligonucleotide comprising a C-5 methylcytosine and which recognizes and binds an allosteric site on DNA methyltransferase thereby inhibiting DNA methyltransferase activity is...
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7125856 |
Angiogenic growth factors for treatment of peripheral neuropathy
A method for treating peripheral neuropathy, particularly ischemic peripheral neuropathy, is provided. The method involves administering to subjects in need of such treatment an effective amount of...
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7125717 |
Metabolically activated recombinant viral vectors and methods for their preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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7125687 |
Presenilin enhancers assays
The invention provides methods and compositions relating to pen polypeptides having pen-specific structure and activity, related polynucleotides and modulators of pen function. The invention...
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7122527 |
Use of antisense oligonucleotides to inhibit the expression of human Akt-1
New antisense oligonucleotide compounds inhibit expression of Akt-1 and also induce cytotoxicity in several cancer cell lines.
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7122372 |
Peptide useful in immunomodulation
The present invention provides peptides and polynucleotides, and their use for immunomodulation, immunotherapy and vaccine particularly for anti-cancer therapy, and for diagnosis purposes. The...
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7122343 |
Methods to alter levels of a DNA repair protein
An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The...
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7122181 |
Lentiviral vector-mediated gene transfer and uses thereof
The present invention provides lentiviral vectors that are useful in human gene therapy for inherited or acquired proliferative ocular disease. It furnishes methods to exploit the ability of...
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7122180 |
DNA vectors containing mutated HIV proviruses
The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are...
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7119078 |
Technology of intracellular delivery of DNA oligonucleotides to improve drug activity
The present invention relates to methods of intracellular delivery of oligonucleotides. More particularly, the present invention relates to the use of the delivery system to deliver G-quartet...
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7119077 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7115582 |
HoxD3 and HoxA3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7115581 |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7115580 |
Antisense modulation of B7 protein expression
Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with...
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