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7183262 |
Method for selective expression of therapeutic genes by hyperthermia
A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide...
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7183111 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7183105 |
Eubacterial minicells and their use as vectors for nucleic acid delivery and expression
Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7183089 |
Method for enhancing production of isoprenoid compounds
The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of...
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7183054 |
Assay for identifying biological targets of polynucleotide-binding compounds
The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also...
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7179797 |
Methods and compositions for treating prostate cancer using DNA vaccines
A DNA vaccine for the treatment of prostate cancer, comprising a plasmid vector comprising a nucleotide sequence encoding prostatic acid phosphatase (PAP) operably linked to a transcription...
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7179796 |
Antisense modulation of PTP1B expression
Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic...
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7179795 |
Nucleic acids encoding chimeric proteins comprising BMP-2 and a proteinase inhibitor
This invention relates to an agent for producing a pharmaceutical drug for postoperative use after removal of bone tumors produced from a nucleic acid by linking a known sequence for promoting bone...
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7179646 |
Gene expression using T cell factor responsive element
Disclosed are DNA elements and constructs useful for obtaining tumor-selective gene expression in tumors having a mutated β-catenin/APC pathway. In particular, the use of these constructs to...
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7179645 |
Ii-Key/antigenic epitope hybrid peptide vaccines
Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope. In addition,...
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7179487 |
Hydrogels of water soluble polymers crosslinked by protein domains
A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the...
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7176188 |
Method of lethally sensitizing human and animal cells
The present invention relates to a method, nucleic acid and amino acid sequences to sensitizing human or animal cells to be killed by chemical entities or irradiation. Particularly, the present...
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7176187 |
Fusion proteins based upon somatostatin receptors
The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins contain a reporter protein, e.g. a...
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7176186 |
Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
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7176178 |
Nuclear targeting by means of bacterial proteins
A nuclear delivery construct comprises (i) protein H or a fragment or derivative thereof that is capable of being targeted to the nucleus of a eukaryotic cell; and associated therewith (ii) one or...
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7175840 |
Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present...
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7175658 |
Artificial vascular grafts, their construction and use
The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on...
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7173015 |
Inhibition of Syk kinase expression
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
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7173014 |
HIV-specific synthetic oligonucleotides and methods of their use
Disclosed are synthetic oligonucleotides having a nucleotide sequences specifically complementary to nucleotides 324 to 345 of a conserved gag region of the HIV-1 genome, the oligonucleotide...
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7169766 |
Methods and compositions for treating hepatitis C virus
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
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7169764 |
Promoter for smooth muscle cell expression
Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing...
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7166467 |
Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The...
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7166433 |
Transductin-1 and transductin-2 and applications to hereditary deafness
The invention provides an isolated or purified nucleic acid molecule consisting essentially of the nucleotide sequence encoding transductin-2 (TDC2), related and derivative nucleic acid molecules,...
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7166302 |
Complexing agents for compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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7166298 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
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7163930 |
Pharmaceutical compositions and methods relating to fucans
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
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7163929 |
Methods and compositions for treating flaviviruses and pestiviruses
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
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7163927 |
Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7163926 |
Adjuvant-containing vaccines
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic...
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7163925 |
p16 expression constructs and their application in cancer therapy
A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, expression constructs are provided that...
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7163806 |
Somatic cells with ablated PrP gene and methods of use
The present invention comprises a method for producing mammalian therapeutics free from prion contamination and cells for use in such methods. Such therapeutics are produced in somatic cells having...
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7163695 |
Histidine copolymer and methods for using same
The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues,...
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7163677 |
Cationic polymers having degradable crosslinks
A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a...
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7160869 |
Biologically active metal-containing nucleic acids
The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal...
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7160868 |
Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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7157439 |
HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7157438 |
Rhob as a suppressor of cancer cell growth and cell transformation
The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor of malignant cell transformation, and modulator of oncogenic signaling, wherein introducing RhoB directly, or...
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7157437 |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
The invention provides new methods of preventing and/or treating herpes virus infections, particularly reducing infection, one or more symptoms and recurrence of one or more symptoms of herpes...
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7157436 |
Therapeutically useful synthetic oligonucleotides
The present invention provides a composition and method comprising a 2–20 base 3′-OH, 5′-OH synthetic oligonucleotide (sequence) selected from the group consisting of (G x T y ) n , (T y G x...
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7157435 |
Methods for modulation of the effects of aging on the primate brain
The invention provides a clinically useful protocol for delivery of recombinant nervous system growth factors into the aging mammalian brain. The invention is particularly useful in tempering and...
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7157079 |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor...
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7153839 |
Method of protecting erythricytes, in particular for improvement of blood cytopenia
The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory...
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7151090 |
Methods for enhancing graft survival by modulating heme oxygenase activity
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein....
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7151082 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7150970 |
Methods of inhibiting VEGF-C
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for VEGF-C, and further provides methods of reducing expression of VEGF-C in cells (e.g., cancer cells).
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7150873 |
Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers...
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7148205 |
Intravascular delivery of non-viral nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7148204 |
Antisense modulation of bcl-x expression
Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred....
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