Matches 151 - 200 out of 3090 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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7256036 Modified adenoviral fiber and target adenoviruses  
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said...
7255857 Lysyl oxidase-like 1 (LOXL1) and elastogenesis  
Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions,...
7255856 Lysyl oxidase-like 1 (LOXL1) and elastogenesis  
Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions,...
7254487 Methods for determining therapeutic index from gene expression profiles  
This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are...
7253151 Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant  
The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant...
7253150 Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin  
The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of...
7250407 Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders  
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I;...
7250406 Compositions and methods for the acceleration of protein secretion dynamics  
The present invention provides compositions and methods for modulating the secretion of transcriptionally regulated proteins from recombinant cells. More particularly, the present invention...
7250405 Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy  
The intramuscular electroporated injection of a protease-resistant growth hormone-releasing hormone (“GHRH”) cDNA into rat dams at 16 days of gestation resulted in the enhanced long-term growth...
7250404 Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response  
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate...
7250403 Biodegradable immunomodulatory formulations and methods for use thereof  
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
7247620 Method of treating skin wounds with vectors encoding hepatocyte growth factor  
The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF),...
7247619 Viral vectors useful in induction of humoral or cellular immunity  
The invention features recombinant viral vectors that take advantage of the activity of picornaviral protein 3A in modulating cytokine secretion and antigen presentation on MHC Class I (MHC I),...
7247618 Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling  
Described herein are methods of inhibiting M-CSF activity, and, in particular, M-CSF/c-fms dependent cell signaling. In a first embodiment of the invention, one administers to a mammal viral...
7247439 Method of evaluating a patient antibody response to envelope proteins of a virus  
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
7247288 Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids  
Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite...
7244715 Vaccines containing ribavirin and methods of use thereof  
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
7244714 Methods of delivering aerosolized polynucleotides to the respiratory tract  
Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery...
7244438 Uses for polycationic compounds  
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
7244423 Methods for therapy of neurodegenerative disease of the brain  
A specific clinical protocol for use toward therapy of defective, diseased and damaged cholinergic neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative...
7244422 Vaccines containing ribavirin and methods of use thereof  
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
7241744 Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone  
The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding...
7241743 Sir2α-based therapeutic and prophylactic methods  
This invention provides methods for treating and for inhibiting the onset of cancer in a subject comprising administering an agent that inhibits the ability of Sir2α to inhibit p53-dependent...
7241742 CYP1B1 nucleic acids and methods of use  
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
7241618 Expression system  
The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine...
7241617 Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci  
Use of a negative-sense RNA virus vector has enabled transfer of nucleic acid into nerve cells. The method of this invention can be used for introducing a gene efficiently into nerve cells...
7241596 Methods and reagents for combined PCR amplification and hybridization probing  
An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite...
7241440 Vaccines containing ribavirin and methods of use thereof  
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
7238675 Antisense antibacterial method and composition  
The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use....
7238674 Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors  
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of...
7238673 Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor  
A method for the direct in vivo transformation of cells in and surrounding a solid tumor is disclosed. This method is based on the site-specific delivery of proteins to solid tumors and to tissue...
7238672 Chimeric lyssavirus nucleic acids and polypeptides  
The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a ...
7238346 High capacity recombinant adenoviral vector for treatment of hemophilia A  
The invention relates to adenoviral vectors. More particularly, this invention relates to recombinant high capacity adenoviral vectors which can be employed in the treatment of hemophilia A, as...
7235534 Antisense strategy to modulate estrogen receptor response (ER α and/or ER β )  
The present invention provides novel antisense oligonucleotides that target the genes and mRNAs encoding mammalian Estrogen Receptors (ER) alpha and/or beta and modulate the receptors' responses....
7235236 Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function  
The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart...
7235233 Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts  
The invention provides means and methods for transduction of a skeletal muscle cell and/or a muscle cell specific precursor thereof. Provided is the use of a gene delivery vehicle derived from an...
7232808 Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)  
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for MnSOD, and further provides methods of reducing expression of MnSOD in cells (e.g., cancer cells).
7232807 Compositions and methods for binding agglomeration proteins  
Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one...
7232806 MicroRNA molecules  
In Caenorhabditis elegans , lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is...
7232682 Expression vectors encoding epitopes of target-associated antigens and methods for their design  
The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing...
7229976 Modulation of forkhead box O1A expression  
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
7229975 DNA immunization against chlamydia infection  
Nucleic acid, including DNA, immunization is used to generate a protective immune response in a host, including humans, to a serine-threonine kinase (STK) of a strain of Chlamydia . A...
7229974 G cap-stabilized oligonucleotides  
Oligonucleotides of the formula 5′-(CAP)-(Oligo)-(CAP)-3′ are disclosed...
7229959 Supplemented fibrin matrix delivery systems  
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
7226912 Hepatitis C virus non-structural NS3/4A fusion gene  
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides,...
7223743 Hepatitis C virus codon optimized non-structural NS3/4A fusion gene  
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
7223742 Enhanced solubility of recombinant proteins  
Disclosed are methods for improving the solubility of a protein of interest produced recombinantly by expressing the protein of interest as a fusion protein with a member of the 14-3-3 family of...
7223741 Immunostimulatory nucleic acid molecules  
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
7223740 Vectors for enhanced expression of VEGF for atrial disease treatment  
The invention provides a vector which is capable of the expression of a vascular endothelial growth factor wherein the vector comprises a modified PCMV promoter. The invention further provides use...
7223739 Adjuvanted genetic vaccines  
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
Matches 151 - 200 out of 3090 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >