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6559125 |
Polyamide-alkylator conjugates and related products and method
The present invention is based on the surprising and unexpected discovery of new and useful polyamide-alkylator conjugates. As a result of their DNA binding properties, polyamides deliver reactive...
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6558952 |
Treatment for diabetes
Methods and compositions for treating diabetes mellitus in a patient in need thereof are provided. The methods include administering to a patient a composition providing a gastrin/CCK receptor...
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6558702 |
Method of modifying the release profile of sustained release compositions
The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a...
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6558675 |
Mutant human hepatitis B viral strain and uses thereof
An isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) of Cell. Also, an isolated nucleic acid encoding a...
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6558673 |
Complexes of immunogens derived from RSV surface glycoprotein G covalently coupled to a support molecule
A complex of an immunogen and a support molecule, characterized in that the immunogen is coupled covalently to a support molecule, wherein the support molecule is a polypeptide fragment which is...
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6555525 |
Microencapsulation and sustained release of oligonucleotides
This invention relates to a composition, and method of forming and using the composition, for the sustained release of oligonucleotides, in particular antisense ODNs. The sustained release...
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6555369 |
Method of stable integration of DNA into neurons
The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene...
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6555108 |
Implanting HSV-TK retrovirus producing cells to treat tumors
The present invention discloses compositions and methods for selective killing neoplastic cells. Retroviral vectors are used to selectively express a gene in neoplastic cells. The gene or gene...
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6552007 |
Use of somatostatin analogs for the delivery of anti-tumor drugs to tumor cells
A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its...
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6552006 |
Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
The present invention features methods for treatment or prevention of infection by intracellular pathogens (e.g., Mycobacterium species) by administration of an immunomodulatory nucleic acid...
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6552005 |
Molecular chemotherapy enhancement of radiotherapy
The present invention provides a new approach for cancer treatment by utilizing gene therapy combined with radiation therapy to enhance cytotoxicity in malignant cells. Specifically, the present...
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6552004 |
Delivery system for entrapping charged macromolecules and a method for preparing same
The present invention relates to a new delivery system and method for producing same. The delivery system is a biphasic system of delivering charged macromolecules and comprises a negatively...
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6552003 |
Muscle reinnervation and motor axon sprouting by administering DNA sequences encoding NT-3 and CNTF
The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for...
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6551826 |
Antisense modulation of raidd expression
Antisense compounds, compositions and methods are provided for modulating the expression of RAIDD. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6551821 |
Brain cyclic nucleotide gated ion channel and uses thereof
The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition...
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6551779 |
Helicobactor catalase nucleotide sequences, their production and use
Disclosed are amino acid sequences of polypeptides reacting with antibodies to Helicobacter pylori (HP), DNAs coding therefor, vectors containing said DNAs, transformants containing said vectors,...
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6551618 |
Compositions and methods for delivery of agents for neuronal regeneration and survival
Devices useful in the delivery of DNA encoding neurotrophic agents, anti-fibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous...
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6551598 |
Vaccination against canine herpesvirosis and vaccines therefor
Use of a CHV antigen for the preparation of a vaccine against canine herpesvirosis, which is intended to be administered to gestating bitches as close as possible to whelping, preferably during the...
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6551588 |
Tumor radiosensitization using gene therapy
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method...
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6551587 |
Vectors for tissue-specific replication
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and...
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6551586 |
Malaria vaccine based upon the addition of a MSA1 peptide
The present invention relates to an expression vector which expresses a malaria MSA1 peptide in combination with a signal peptide and anchor peptide in a host animal. The MSA1 peptide is combined...
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6548302 |
Polymers for delivery of nucleic acids
The present invention relates to compositions and methods for delivery of nucleic acids. In particular, the invention provides a polymeric delivery formulation including a nucleic acid to be...
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6548301 |
Retroviral gene transfer vectors
The invention relates to novel retroviral gene transfer vectors, preferably expression vectors, which, because of a reduced content of viral genes, are distinguished by a higher safety standard and...
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6548251 |
Inhibition of molecular and biological processes using modified oligonucleotides
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula...
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6548060 |
Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators
Aminoacyl-tRNA synthetases are the enzymes catalyzing ligation of their cognate amino acids and tRNAs. Human glutaminyl-tRNA synthetase (QRS) consists of the unique N-terminal extension (236 aa)...
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6548055 |
Immunologic enhancement with intermittent interleukin-2 therapy
A method for activating a mammalian immune system entails a series of IL-2 administrations that are effected intermittently over an extended period. Each administration of IL-2 is sufficient to...
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6544959 |
High affinity nucleic acid ligands to lectins
This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin...
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6544958 |
Therapy of respiratory influenza virus infection using free and liposome-encapsulated ribonucleotides
The present invention relates to novel ribonucleotide oligonucleotides (RNOs) that are specifically designed to inhibit viral replication. The RNOs are capable of binding to both the negative and...
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6544957 |
Methods and reagents for facilitating transcription
A previously unknown histone acetylase inhibitor, 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, termed “scriptaid,” can be used to enhance transcription. Scriptaid...
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6544956 |
Lunasin peptides
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian,...
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6544955 |
Method of sensitizing tumor cells with adenovirus E1A
The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell...
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6544781 |
Non-defective Epstein-Barr viral vector
The present invention relates to a viral vector system derived from Epstein-Barr Virus (EBV), where the transgene is effectively inserted into the EBV major internal repeat region (IR1) without...
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6544522 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis ...
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6544507 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumor specific transcription factor binding sites in place of one or more wild type transcription factor binding...
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6541459 |
Soluble herpesvirus glycoprotein complex vaccine
The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA...
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6541458 |
Feline calicivirus genes and vaccines in particular recombinant vaccines
The invention relates to the sequence of the capsid gene and a corresponding cDNA sequence, of a dominant FCV strain called FCV 431. It also relates to the sequence of the capsid gene as well as...
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6541457 |
Mammalian IAP gene family, primers, probes and detection methods
Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to...
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6541255 |
Engraftable human neural stem cells
Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give...
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6541036 |
Treatment of tumors with oligonucleotides directed to insulin-like growth factor-I receptors (IGF-IR)
A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro-apoptotic agent for a period of time,...
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6541022 |
Mineral and cellular patterning on biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6540995 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
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6538028 |
Method for inhibiting complement activation
A method of inhibiting complement activation, particularly by a transplanted tissue, in a warm-blooded vertebrate. The method includes administering a therapeutically effective amount of a platelet...
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6537974 |
Method of treating arrhythmias
A method for treating arrhythmia in mammals is provided comprising administering a low dose of an adenosine receptor agonist of the Formula I: wherein R 1 is an optionally substituted...
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6537973 |
Oligonucleotide inhibition of protein kinase C
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC....
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6537972 |
Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
The present invention relates to the identification of a number of human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus infection. These...
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6537964 |
Reversal of multidrug resistance in human colon carcinoma cells
The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects...
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6537814 |
Compositions and methods for altering the biodistribution of biological agents
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6537542 |
Targeted introduction of DNA into primary or secondary cells and their use for gene therapy and protein production
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or...
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6537541 |
Implantation of HSV-TK retrovirus producer cells to destroy glioma
The present invention discloses compositions and methods for selectively killing neoplastic cells. Retroviral vectors are used to selectively express a gene in neoplastic cells. The gene or gene...
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