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6692736 |
Cell-specific adenovirus vectors comprising an internal ribosome entry site
Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional...
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6689758 |
Gene therapy method
The invention relates to the use of an Egr-1 transcription factor polypeptide or a biologically active fragment thereof, and to nucleic acid molecules encoding such polypeptides, in the manufacture...
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6689757 |
Methods for vaccination and vaccines therefor
The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope...
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6689370 |
Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
A therapeutic composition comprising (i) at least one antigen or at least one in vivo generator of a compound comprising an amino acid sequence and (ii) at least one adjuvant comprising at least...
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6686339 |
Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of...
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6686338 |
Enzyme inhibitors for metabolic redirection
A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs...
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6683064 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
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6683061 |
Enzyme catalyzed therapeutic activation
This invention provides novel substrate compounds that selectively inhibit the proliferation of pathological cells, for example, pathological calls that endogenously overexpress a target enzyme...
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6683059 |
Mini-E1A gene and gene products
The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A...
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6683058 |
Methods for therapy of neurodegenerative disease of the brain
A specific clinical protocol for use toward therapy of defective, diseased and damaged cholinergic neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative...
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6683057 |
Method of inhibiting smooth muscle cell proliferation
The present invention relates, in general, to vascular smooth muscle proliferation and, in particular, to a method of inhibiting arterial and venous smooth muscle proliferation resulting, for...
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6683047 |
Method of inhibiting transcription utilizing nuclear receptors
This invention provides a method of inhibiting the transcription of a gene, which is activated by AP-1 or an AP-1 component, comprising binding AP-1 or the component with a nuclear receptor so as...
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6683045 |
Nucleosides for imaging and treatment applications
Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic...
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6682928 |
Cells expressing anti-Fc receptor binding components
Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once...
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6682729 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression...
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6682715 |
Nucleosides for imaging and treatment applications
Methods of diagnosing and/or of treating tumors by administering a nucleoside analog which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite,...
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6680301 |
Transfer of molecules into the cytosol of cells
The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells...
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6680169 |
Poliovirus replicons encoding therapeutic agents and uses thereof
The invention pertains to methods of delivering a polypeptide to a cell comprising (a) contacting a cell with a replicon having a non-poliovirus nucleic acid substituted for a nucleic acid which...
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6680068 |
Drug delivery formulations and targeting
The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped...
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6680061 |
Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers...
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6680060 |
Hepatitus A virus vaccines
A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without...
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6680059 |
Vaccines containing ribavirin and methods of use thereof
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
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RE38385 |
Storage of materials
A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be...
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6677315 |
Nucleosides for imaging and treatment applications
Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic...
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6677314 |
Nucleosides for imaging and treatment applications
Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic...
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6677313 |
Method for gene therapy using nucleic acid loaded polymeric microparticles
The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form,...
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6677312 |
Methods for restoring wild-type p53 gene function
Methods are provided for restoring wild-type p53 gene function to a cell. Such methods include gene therapy. Typically, this will stop tumor cells from proliferating.
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6677311 |
Inducible HSV-TK in transformed cell populations
The present invention discloses a new selective method for inducibly and genetically ablating specific cell lineages in transgenic cell populations, e.g., in transgenic animals. The new method,...
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6677302 |
Compositions and methods for the treatment of viral disorders
This invention relates to compositions and methods for the treatment of virus infections and other viral-associated disorders. Compositions comprise an inducing agent and an anti-viral agent. The...
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6677299 |
Method to increase cerebral blood flow in amyloid angiopathy
The present invention provides a method for decreasing cerebral vasoconstriction in a subject suffering from chronic or acute cerebral amyloid angiopathy which comprises administering to the...
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6677155 |
Triple hybrid amplicon vector systems to generate retroviral packaging lines
The present invention relates to a triple hybrid vector amplicon system comprising genetic elements derived from Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV) or Adeno-Associated Virus...
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6677153 |
Antisense antibacterial method and composition
The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use....
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6677135 |
Ret ligand (RetL) for stimulating neutral and renal growth
Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating...
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6677127 |
Nucleic acid respiratory syncytial virus vaccines
Vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such...
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6676937 |
Compositions and methods for modulating vascularization
The present invention generally provides methods for modulating formation of new blood vessels. In one embodiment, the methods include administering to a mammal an effective amount of granulocyte...
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6676935 |
Tissue specific adenoviral vectors
Host cell specific adenovirus vehicles are provided for transfecting target host cells. By providing for transcriptional initiating regulation dependent upon transcription factors that are only...
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6673778 |
Enzyme inhibitors for metabolic redirection
A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs...
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6673777 |
Guanylhydrazones useful for treating diseases associated with T cell activation
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target...
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6673776 |
Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate...
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6673612 |
Micellar systems
A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for...
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6673549 |
Genes expressed in C3A liver cell cultures treated with steroids
The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in human C3A liver cell cultures treated with steroids or synthetic steroid...
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6670334 |
Method and compositions for treating the inflammatory response
Agonists of A 2A adenosine receptors optionally, in combination with a Type IV phosphodiesterase (PDE) inhibitor are effective for the inhibition of an inflammatory response in mammalian tissue,...
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6670333 |
Methods and compositions for inhibiting angiogenesis
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits...
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6670332 |
Complex cationic lipids having quarternary nitrogens therein
Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
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6670321 |
Prevention and treatment for retinal ischemia and edema
The claimed invention relates to methods of treating retinopathy, retinal ischemia and/or retinal edema comprising administering an integrin antagonist, a leukocyte adhesion inducing cytokine...
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6670183 |
88kDa tumorigenic growth factor and antagonists
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88...
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6670176 |
Adeno-associated virus capable of expressing factor IX protein and cells comprising the same
The subject invention concerns a recombinant adeno-associated virus vector characterized as being capable of delivering and expressing at least one mammalian gene into a genome of a mammalian host...
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6669936 |
Retroviral vectors
Retroviral vector production systems for producing lentivirus-based vector particles which are capable of infecting and transducing non-dividing target cells, wherein one or more of the auxiliary...
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6667295 |
DNA vaccine against feline immunodeficiency virus
The present invention is directed to vaccine compositions that can be used to protect cats against feline immunodeficiency virus. More particularly, the present invention relates to polynucleotide...
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6667294 |
Microencapsulated DNA for vaccination and gene therapy
A microparticle contains DNA coding for a polypeptide and oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a...
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