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6800462 |
Production of recombinant proteins in vivo and use for generating antibodies
The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the...
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6797704 |
Systemic delivery of compounds through non-invasive bladder administration
The present invention features methods of administering a therapeutic agent to a patient's lymph nodes by instillation of microparticles or nanoparticles comprising a biocompatible polymer and the...
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6797703 |
Gene therapy using TGF-β
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factory-β (TGF-β) superfamily. TGF-β gene...
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6797702 |
Methods and compositions comprising DNA damaging agents and P53
The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor suppressor...
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6797505 |
Recombinant AAV vectors for gene therapy of hemophilia A
The instant invention provides methods and materials for expressing a polypeptide with factor VIII activity comprising administering an rAAV vector encoding a truncated version of human factor...
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6794376 |
Methods and compositions for enhancing diffusion of therapeutic agents through tissue
The present invention provides methods and compositions for enhancing the diffusion of therapeutic agents through mammalian tissue. In one embodiment, invention provides methods and compositions...
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6794369 |
Methods, systems, and kits for intravascular nucleic acid delivery
Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to...
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6794368 |
Composition and method for inducing apoptosis in prostate cancer cells
The present invention relates to a composition and method useful for regulating cell proliferation and cell death in a multicellular organism. The present invention particularly relates to a...
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6794367 |
Solid preparations for oral administration of drugs relating to genes
The invention provides solid preparations for oral administration of gene-related drugs comprising a core containing the gene-related drug with a coating which does not disintegrated in small...
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6794189 |
Polyampholytes for delivering polyions to a cell
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6794188 |
Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells and therapeutic uses thereof
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an...
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6793926 |
Methods for production of a recombinant adeno-associated virus
This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be...
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6790838 |
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Combinations and methods for inducing a semi-synchronous wave of liver cell proliferation in vivo and combinations and methods for inducing a semi-synchronous wave of liver cell proliferation and...
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6790446 |
Campylobacter vaccine
The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also...
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6787524 |
CpG oligonucleotides and related compounds for enhancing ADCC induced by anti-IgE antibodies
The invention relates to a method of stimulating antibody-dependent cellular cytotoxicity to enhance the elimination of IgE-bearing B-cells comprising administering to a mammal an anti-IgE...
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6787356 |
Cell expansion system for use in neural transplantation
The invention provides a method of culturing cells which includes a proliferating step in which the number of precursor cells is expanded and a differentiating step in which the expanded precursor...
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6784164 |
Choline binding proteins for anti-pneumococcal vaccines
The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria,...
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6784163 |
Inhibition of cationic amino acid transporter protein and uses thereof
The present invention provides methods of inhibiting cationic amino acid transport by means of antisense and antibody technology specific for the CAT2 transporter. Further, the present invention...
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6784162 |
Gene therapy method for reducing risk of atherosclerosis
A single point mutation in the human lipoprotein lipase gene which results in an A→G nucleotide change at codon 291 (nucleotide 1127) of the lipoprotein lipase gene, and a substitution of serine...
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6783979 |
Vectors encoding HCN channels and MiRP1
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac...
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6783972 |
Methods for large-scale production of recombinant AAV vectors
Disclosed are HSV-1 amplicons that supply all necessary helper functions required for rAAV packaging and methods for their use. These HSV-1 amplicons have been shown to be capable of rescuing and...
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6783762 |
Product and method for obtaining specific immunization with one or more antigens
A large number of recombinant of viral and bacterial systems has been engineered as vectors to express foreign genes for vaccination and/or gene therapy. A common problem is the immune response to...
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6783756 |
Methods for regulating gene expression
A method for regulating expression of a tet operator-linked gene in a cell of a subject is disclosed. In one embodiment, the method involves introducing into the cell a nucleic acid molecule...
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6780850 |
Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood
The present invention is a complex of a polynucleotide having a property of specifically binding to a target protein together with a protein that stabilizes the polynucleotide from degradation and...
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6780847 |
Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins
An isolated and purified nucleic acid molecule that encodes a protein or peptide comprising at least nine contiguous amino acids of SEQ ID NO:2, wherein the at least nine contiguous amino acids...
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6780642 |
Association of SIM2 with cancer
Disclosed are methods of detecting cancer in a biological sample by detecting SIM2 nucleic acid or protein in the sample. Also disclosed are methods for treating cancer and identifying compounds...
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6780639 |
Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization
The present invention is related to an antibiotic inducible/repressible genetic construct for controlling the transcription of a gene of interes: by a cell. The genetic construct comprises a...
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6780614 |
Modified factor VIII cDNA and its use for the production of factor VIII
A modified Factor VIII cDNA is disclosed wherein the B-domain of the wild type factor cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in two locations of the Factor VIII...
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6780429 |
Chain-shortened polynucleotide and method for preparation thereof
The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2′-5′ phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a...
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6780428 |
Unimolecular polymeric micelles with an ionizable inner core
The present invention describes the preparation of unimolecular polymeric micelles (UPM) that bear a hydrophilic shell and a potentially ionizable and relatively hydrophobic core at a determined pH...
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6780409 |
Glutamic acid decarboxylase (GAD) based delivery system
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative...
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6780406 |
Inhibition of vascular smooth muscle cell proliferation administering a thymidine kinase gene
A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured...
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6777396 |
Feed for livestock
A composition for livestock feed, comprising a feed for livestock and at least two additives selected from the group consisting of nucleic acid, glutamine and glutamic acid; and a method for...
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6777000 |
In-situ gel formation of pectin
In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically...
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6776987 |
Enhancement of cardiac chronotropy
Molecularly-mediated and cellular-based β-adrenergic receptor-dependent biological pacemakers are disclosed. Methods of using these compositions to improve cardiac chrontropic responsiveness by...
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6776985 |
Encapsulated cells producing viral particles
The present invention relates to encapsulated cells producing viral particles, especially retroviral particles containing the genome of a retroviral vector carrying therapeutic genes, to methods...
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6774180 |
Synthesis of high molecular weight non-peptidic polymer derivatives
High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the...
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6774120 |
Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
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6774119 |
HERPES SIMPLEX VIRUS TYPE 1 (HSV-1)-DERIVED VECTOR FOR SELECTIVELY INHIBITING MALIGNANT CELLS AND METHODS FOR ITS USE TO TREAT CANCERS AND TO EXPRESS DESIRED TRAITS IN MALIGNANT AND NON-MALIGNANT MAMMALIAN CELLS
Disclosed is a method of selectively inhibiting the growth of malignant cells in mammals, including humans. The method selectively inhibits the growth of malignant cells of all varieties, and is...
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6774118 |
Therapeutic use of CIS-element decoys in vivo
The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes...
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6774117 |
MN gene and protein
A new gene—MN—and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and recombinant proteins are provided....
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6773712 |
Parasitic helminth cuticlin proteins and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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6773701 |
Expression enhancer for protein synthesis inhibitory genes
The objects of the present invention are to reveal a specific combination of human interferon-α subtypes that remarkably enhances the expression of protein synthesis inhibitory genes, and to...
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6770633 |
Ribozyme therapy for the treatment of proliferative skin and eye diseases
As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which...
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6770632 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to...
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6770631 |
Non-identical genes and their application in improved molecular adjuvants
The invention provides a linear concatamer of at least two non-identical DNA sequences which, by virtue of third base redundancy of the genetic code of the codons, each encode the same polypeptide...
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6770479 |
Anthrax vaccine
Using the nontoxic PA protein from B. anthracis , a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
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6770274 |
Viral mutant HSV mediated destruction of neoplastic cells
The present invention is drawn to compositions and methods for selectively killing neoplastic cells. Altered viruses are utilized which are capable of replication in neoplastic cells while sparing...
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6767928 |
Mineralization and biological modification of biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6767739 |
Antisense modulation of microsomal triglyceride transfer protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of microsomal triglyceride transfer protein. The compositions comprise antisense compounds, particularly...
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