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6841168 |
Method for the preservation of biologically-active material
Biologically-active material can be preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose. The method involves forming a coacervate of the...
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6838447 |
Particulate compositions for chemical synthesis
Disclosed are compositions that include triboelectrically chargeable nucleotide particles of less than 50 μm diameter and carrier particles. In one example, a substrate is selectively patterned...
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6838446 |
Vector for expression of GPI-enzyme hybrid
This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatidylinositol (GPI addition to a prodrug activating enzyme to enable...
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6838445 |
Tumor antigen peptide originating in SART-1
To provide a tumor antigen peptide derived from SART-1 and a derivative thereof, possessing functionally equivalent characteristics thereto; or a therapeutic agent, prophylactic agent or the like...
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6838444 |
Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation...
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6838285 |
Site specific recombinase based method for producing adenoviral vectors
Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In...
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6838283 |
Antisense modulation of survivin expression
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6838279 |
Herpes simplex virus type 1 (HSV-1)-derived vector for selectively inhibiting malignant cells and for expressing desired traits in malignant and non-malignant mammalian cells
Disclosed is an HSV-1-derived vector containing a DNA having a functional LAT promoter, or operative fragment thereof, a deletion in both copies of the HSV-1 LAT gene, and a deletion in both copies...
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6838275 |
Human G-coupled protein receptor kinases and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6835718 |
Biocleavable micelle compositions for use as drug carriers
This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other...
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6835395 |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
Lipidic compositions with superior characteristics for in vivo delivery of oligodeoxynucleotides (ODN) can easily and efficiently be made in the form of small multilamellar vesicles. The...
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6833351 |
Method of treating anemia caused by ribavirin treatment of hepatitis C using erythropoietin alpha
Claimed and disclosed is a new use for a previously approved drug: erythropoietin. The present invention teaches using Erythropoetin to treat anemia caused by the combined treatment of Ribavirin...
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6833237 |
Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use
Genes and the proteins encoded thereby that are involved in stroke response and/or are regulated by FK506 are disclosed. These genes were discovered using in vivo or in vitro stroke models by...
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6831071 |
Synthesis of biologically active compounds in cells
This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of...
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6831070 |
Delivery of therapeutic gene products by intestinal cell expression
The present invention provides methods of delivering a secreted protein into the bloodstream of a mammal. A nucleic acid molecule encoding the protein is introduced into the gastrointestinal tract...
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6828148 |
Miniribozymes active at low magnesium ion concentrations
This invention is directed to a class of miniribozymes, capable of hybridizing with a target RNA to be cleaved and exhibiting very high cleavage rates at low Mg 2+ concentration. The miniribozymes...
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6828138 |
Recombinant sendai virus vector including a gene encoding a chemokine
A recombinant Sendai virus vector expressing chemokine is provided. This vector enables large quantity production of clinically useful chemokines. It is also useful for treatment of diseases that...
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6828105 |
Antisense antiviral agent and method for treating ssRNA viral infection
The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment...
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6827942 |
Composition and method of use
A liquid composition comprising an alcohol or mixture thereof in sufficient quantity to grow hair in an area of canine or feline skin wherein alopecia has occurred.
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6825176 |
E2 displacement assay for identifying inhibitors of HPV
The present invention generally relates to an assay for identifying inhibitors of Human Papillomavirus (HPV), comprising: a) contacting a HPV E2 transactivation domain with a probe to form a...
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6825174 |
Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
A pharmaceutical composition effective for preventing and alleviating bronchoconstriction, lung allergy(ies) and inflammation comprises a surfactant and an oligonucleotide anti-sense to an...
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6825164 |
Method to increase cerebral blood flow in amyloid angiopathy
The present invention provides a method for decreasing cerebral vasoconstriction in a subject suffering from chronic or acute cerebral amyloid angiopathy which comprises administering to the...
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6824771 |
Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
A modified adenovirus capable of overcoming the problem of low level of coxsackle-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber...
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6824770 |
Adenovirus gene expression system
The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of...
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6821957 |
Vectors and methods for immunization or therapeutic protocols
The present invention shows that DNA vaccine vectors can be improved by removal of CpG-N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of expression,...
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6821956 |
Therapeutic use of cis-element decoys in vivo
The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes...
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6821955 |
Macroaggregated protein conjugates as oral genetic immunization delivery agents
This invention relates to the development of an expression vector containing an antigenic genomic sequence, which is bound to an aggregated protein-polycationic polymer conjugate. More particularly...
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6821948 |
Conjugate for mediating cell, compartment or membrane-specific transport of active substances
The present invention relates to conjugates for mediating a cell-specific, compartment-specific or membrane-specific to methods of active substances. The invention also relates to methods of...
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6821776 |
Reconstituting retroviral vector (recon vector) for targeted gene expression
The present invention relates to a retroviral vector which is especially applicable as a safe gene transfer vehicle for targeted gene therapy. Said retroviral vector comprises one or more promoters...
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6821264 |
Gene delivery device and gene delivery method
A gene delivery device for localizing and enhancing the efficacy of gene transfer that provides a contact surface for contacting with a tissue site. By applying a pharmaceutical composition...
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6818628 |
Polynucleotide vaccine formula in particular against bovine respiratory pathology
Disclosed and claimed are compositions for inducing in a bovine host an immunological response against bovine respiratory syncytial virus or bovine viral diarrhea virus containing at least one...
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6818627 |
Functional fragments of HIV-1 Vpr protein and methods of using the same
Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's...
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6818626 |
Chelating systems for use in the delivery of compounds to cells
Chelator containing compounds are utilized in the delivery of molecules, polymers, nucleic acids and genes to animal cells. At least one chelator such as crown ether is attached to a polymer and...
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6818444 |
Canine and feline proteins, nucleic acid molecules and uses thereof
The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine...
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6818442 |
AIDS DNA vaccine that prevents SIVmac239 virus infection in monkeys
The present invention relates to a plasmid carrying simian immunodeficiency virus (SIV)-derived genes. Particularly, the present invention relates to the plasmid pSIV/GE which carrys gag, protease,...
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6818210 |
Myocardial grafts and cellular compositions useful for same
Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be...
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6815432 |
Methods for encapsulating plasmids in lipid bilayers
Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize...
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6815431 |
Methods for therapy of neurodegenerative disease of the brain
A specific clinical protocol for use toward therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as...
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6815430 |
Gene expression base sequences for therapeutic use and drugs for gene therapy
The base sequence for the expression of a therapeutic gene and the medicament for gene therapy are disclosed. There is also disclosed the base sequence for the expression of a therapeutic gene,...
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6815429 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable both decreasing the immunostimulatory...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6814962 |
Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant...
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6812219 |
Methods and compositions for treating flaviviruses and pestiviruses
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
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6812218 |
Lipid derivatives of polythiourea
The present invention relates to novel compounds which make it possible to transfer nucleic acids into cells. These novel compounds are lipid derivatives of polythiourea. They are useful for the in...
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6812217 |
Medical device and methods of use
The present invention provides a medical device that includes a carrier and a polynucleotide, where the carrier has a surface that includes a polymer with which the polynucleotide is associated. In...
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6811775 |
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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6811774 |
Defective recombinant adenoviruses expressing cytokines for antitumor treatment
A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the...
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6809082 |
Synthetic transfection vectors
An inorganic particle, to which is bonded a cell binding component and a nucleic acid, is provided for delivery of a nucleic acid to a cell. The disclosed particle acts as a synthetic vector for...
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6809081 |
Chemotherapeutic composition and method
The present invention relates to a composition and method comprising Mycobacterium phlei ( M. phlei )-DNA (M-DNA), M-DNA preserved and complexed on M. phlei cell wall (MCC), a chemotherapeutic...
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