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6867198 |
Agents and methods for the treatment of proliferative diseases
The present invention provides selective kinase inhibitors of formula (I)
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6867197 |
Method of targeting conjugate molecules to mitochondria
The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such...
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6867196 |
Process for delivering nucleic acids to cardiac tissue
A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently...
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6867195 |
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate...
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6866853 |
Interferon inducing genetically engineered attenuated viruses
The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses...
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6866842 |
Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
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6863892 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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6861414 |
Methods for enhancing graft survival by modulating heme oxygenase activity
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein....
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6858590 |
Vaccines containing ribavirin and methods of use thereof
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
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6858226 |
Fusogenic lipids and vesicles
Novel lipid compounds are provided that may be termed “pro-cationic” in that they are neutral or negatively charged until they are either brought into contact with cellular membranes or are...
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6858225 |
Lipid-encapsulated polyanionic nucleic acid
Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino...
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6858224 |
Method of preventing aggregation of a lipid:nucleic acid complex
Particle aggregation of lipid:nucleic acid complex particles is prevented by incorporating a non-cationic lipid into lipid:nucleic acid complex particles containing a cationic lipid and a nucleic...
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6856913 |
Decentralized patient management method
A system ( 2 ) for evaluating the efficiency of therapeutic treatments of patients ( 40 ) located at remote sites ( 6 ) by communicating a cognitive task to the remote site via a network ( 10 )...
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6855701 |
Gene delivery compositions and methods
The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions...
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6855700 |
Antisense modulation of damage-specific DNA binding protein 1, p127 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Damage-specific DNA binding protein 1, p127. The compositions comprise antisense compounds, particularly...
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6855549 |
Methods and compositions for increasing the infectivity of gene transfer vectors
The present invention involves methods and compositions for increasing the susceptibility of target cells to transduction by gene transfer vectors. Specifically, it is proposed that increasing...
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6855329 |
Surface coating spatially controlled patterns
The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The...
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6855317 |
Immunological herpes simplex virus antigens and methods for use thereof
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
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6855314 |
AAV5 vector for transducing brain cells and lung cells
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic...
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6852709 |
Biologically useful polyphosphates
The present invention provides biodegradable polymers, polymer compositions, particles composed thereof and methods of using same for the controlled release of a biologically active substance to a...
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6852705 |
DNA vaccines for farm animals, in particular bovines and porcines
Improved vaccines or immunogenic or immunological compositions, and methods for making and using the same.
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6852704 |
Reverse gene therapy
The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an...
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6852703 |
Tumor targeted vector
A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use...
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6852530 |
Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
Nucleic acid molecules comprising at least a first signal site and a recombinase gene operably linked to an expression control sequence, such that upon entry into a cell, there is a first signal...
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6852528 |
Human and mouse uroplakin II gene transcriptional regulatory elements
The invention provides new urothelial cell specific transcriptional regulatory sequences derived from human uroplakin II (hUPII), as well as polynucleotide constructs such as adenoviral vectors and...
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6852334 |
Cationic peg-lipids and methods of use
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth...
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6849612 |
Oligonucleotide modulation of cell adhesion
Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise...
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6849611 |
Implantation of biological pacemaker that is molecularly determined
This invention provides for a method of inducing a current in the heart in a subject which comprises contacting a cell of the heart of a subject with a compound in a sufficient amount to induce a...
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6849610 |
Polynucleotide ligands as anti-viral agents
Infectious human cytomegalovirus (HCMV) were isolated in vitro from a pool of randomized sequences after sixteen or 21 cycles of selection and amplification. The ligands characterized exhibited...
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6849272 |
Endosomolytic agents and cell delivery systems
The present invention provides improved cell delivery compositions. In particular, the invention provides biocompatible endosomolytic agents. In a preferred embodiment, the endosomolytic agents are...
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6849255 |
Methods and compositions for enhancing cartilage repair
The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes...
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6846809 |
PEI: DNA vector formulations for in vitro and in vivo gene delivery
The present invention relates generally to the fields of nucleic acid transfection. More particularly, it concerns novel polycation:nucleic acid compositions, methods of preparation of such...
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6846808 |
Plasmid-based vaccine for treating atherosclerosis
A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of CETP and one or more broad range helper T cell epitopes. Administration...
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6846799 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
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6846625 |
Method for identifying validated target and assay combination for drug development
The invention comprises methods useful within a larger process for identifying compounds and/or designing further compounds with activity to produce a desired phenotype (for example, growth...
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6846488 |
Chimeric antigen-enterotoxin mucosal immunogens
The present invention provides methods of inducing immune responses by recombinant antigen-enterotoxin chimeric mucosal immunogens that contain the A2/B subunits of cholera toxin or heat-labile...
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6846482 |
Insect control agent
The invention includes an expression vector engineered to produce double-stranded RNA (dsRNA) within a pest to be controlled. The dsRNA inhibits expression of at least one gene within the pest,...
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6844327 |
Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I;...
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6844326 |
Treatment of alopecia
A composition and method for treating and monitoring alopecia by altering hair follicle cells to produce a cell cycle inhibitor is disclosed.
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6844325 |
Compositions for the treatment and diagnosis of breast cancer and methods for their use
Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or...
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6844324 |
Modular peptide mediated intracellular delivery system and uses therefore
A versatile modular peptide mediated intracellular delivery system is disclosed which may be particularly adapted to facilitate the delivery of therapeutic compounds which are large in size or...
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6841579 |
Diagnosis and treatment of AUR1 and/or AUR2 related disorders
The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides,...
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6841542 |
Transforming growth factor beta (TGF-β) blocking agent-treated stem cell composition and method
The invention relates to TGF-β blocking agent-treated HSC compositions and methods comprising the same. The TGF-β blocking agent-treated stem cells are viable for an extended time in culture...
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6841541 |
Regulation of BCL-2-gene expression
The present invention provides novel anticode oligomers and methods of using them for controlling growth of cancer cells expressing the bcl-2 gene.
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6841540 |
Immunomodulation by genetic modification of dendritic cells and B cells
The present invention provides a CD40-targeted gene delivery system and a CD40-targeted recombinant adenoviral vector for genetic manipulation of dendritic cells and B cells. Also provided are...
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6841539 |
Compositions and methods for topical delivery of oligonucleotides
The present invention relates to compositions and methods which enhance the delivery of oligonucleotides and other nucleosidic moieties via topical routes of administration. Preferred compositions...
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6841538 |
Combination therapy using nucleic acids and radio therapy
The present invention relates to methods for increasing the efficiency of transformation of cycling cells, the methods comprising synchronizing cells at a first stage of the cell cycle, and...
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6841537 |
Combination therapy using nucleic acids and conventional drugs
The present invention relates to methods for increasing the efficiency of transformation of cycling cells, the methods comprising synchronizing cells at a first stage of the cell cycle, and...
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6841362 |
Melanoma differentiation associated gene-7 promoter and uses thereof
The present invention provides for an isolated Mda-7 promoter capable of directing transcription of a heterologous coding sequence positioned downstream therefrom, wherein the promoter is selected...
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6841173 |
Compositions and methods directed towards sore muscles and joints
Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
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