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6900186 |
Method for the prophylaxis and/or treatment of medical disorders
The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflamatory skin disorders, and to genetic...
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6900185 |
Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
The present invention is directed to methods for inhibiting tumor cell growth, causing tumor regression or eliminating tumor cells in a mammal afflicted with a tumor by administering to a...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6899731 |
Controlled delivery of therapeutic agents by insertable medical devices
A medical device and method for transportation and release of a therapeutic agent into a mammalian body are disclosed. The medical device is coated with alternating layers of a negatively charged...
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6897200 |
Oligonucleotide delivery systems for camptothecins
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be...
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6897196 |
pH sensitive lipids based on ortho ester linkers, composition and method
The invention comprises lipid derivatives that rapidly degrade in the pH range from 4.0 to 7.0 and lipidic delivery systems that contain them. These lipid derivatives can be used to modify the...
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6897068 |
Polynucleotide complex delivery
Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not...
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6897057 |
Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the...
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6897016 |
Alteration of sequence of a target molecule
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that...
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6894031 |
Pituitary tumor transforming gene (PTTG) carboxy-terminal peptides and methods of use thereof to inhibit neoplastic cellular proliferation and/or transformation
Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian cells, including cells of human origin, in vitro or in vivo. The inventive method involves...
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6893634 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
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6890912 |
Sunscreen formulations containing nucleic acids
Sunscreen formulations containing nucleic acids are disclosed. The formulations can be used to reduce sunburns, the occurrence of skin cancer, and the occurrence of other ultraviolet radiation...
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6890911 |
Method for the treatment of inflammation
The present invention relates to a mycobacterial deoxyribonucleic acid (B-DNA) preserved and complexed on the mycobacterial cell wall (BCC) and a pharmaceutically acceptable carrier, wherein the...
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6890910 |
Murd protein and gene of Pseudomonas aeruginosa
This invention provides isolated polynucleotides that encode the MurD protein of Pseudomonas aeruginosa . Purified and isolated MurD recombinant proteins are also provided. Nucleic acid sequences...
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6890909 |
Brain-protective agent
A brain-protective agent containing an NF-κB decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a...
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6890908 |
Modified ribozymes
The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced...
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6890557 |
Emulsion formulations for hydrophilic active agents
This invention discloses emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one...
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6890554 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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6890516 |
Method for assessing the effect of a drug on long term memory formation
Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.
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6887906 |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
The present invention relates to compositions and methods which enhance the transport of nucleic acids, especially oligonucleotides at various sites in the alimentary canal of an animal. The...
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6887857 |
Microparticle protection of therapeutic agents
The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically...
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6887856 |
Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
A method of protecting a subject against an agent that elicits production of toxic free radicals, superoxide anions, or heavy metal cations in the subject is disclosed which entails in vivo...
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6887490 |
Gene therapy vehicle comprising dermal sheath tissue
The invention herein described relates to a gene therapy vehicle, comprising dermal sheath tissue and/or cells derived from portions of hair follicles which show pluripotentiality, and which has...
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6884787 |
Antisense modulation of transforming growth factor-beta 3 expression
Antisense compounds, compositions and methods are provided for modulating the expression of transforming growth factor-beta 3. The compositions comprise antisense compounds, particularly antisense...
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6884786 |
Antitumoral composition based on immunogenic polypeptide with modified cell location
Antitumoral compositions can comprise as therapeutic agent one or several immunogenic polypeptides, of which at least one is modified so as to have a cell location different from its native...
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6884785 |
Compositions and methods for the treatment or prevention of autoimmune diabetes
The present invention provides compostions and methods for the prevention or treatment of autoimmune disorders. In particular, the invention methods utilize genetic material encoding at least a...
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6884616 |
DNA-construct for the tissue-specific expression of a blood coagulation factor
A DNA-construct has been disclosed which is suitable for a tissue-specific expression of a blood coagulation factor like Factor IX, which comprises a DNA coding for an amino acid sequence of a...
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6884587 |
Metallization of nucleic acids via metal nanoparticles produced ex-situ
The invention relates to a process for the metallization of nucleic acids, comprising providing tris(hydroxymethyl)phosphine-Au (THP-Au) particles or derivatives thereof, binding said THP-Au...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6884435 |
Microparticles with adsorbent surfaces, methods of making same, and uses thereof
The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for...
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6884431 |
Method for treating proliferative diseases with p27 and fusions thereof
The present invention is directed to a method of vascular proliferative disease by administering in vivo a gene encoding p27.
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6881724 |
Use of magnesium (Mg2+) for the preparation of a therapeutic composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy
Described is the use of magnesium (Mg 2+ ) for the preparation of a therapeutic composition for the introduction of a polynucleotide into a cell in vivo.
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6881723 |
Nucleic acid constructs
Recombinant nucleic acid molecules are described. The molecules have a first sequence encoding a Hepatitis B virus core antigen and a second sequence encoding at least one T cell epitope inserted...
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6881577 |
Method for improving transfection efficiency
The invention relates to a method for improving transfection efficiency through the use of K16-peptides. In addition, the invention further relates to novel K16-peptides, including a K16-CYC peptide.
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6881412 |
Modified live Flavobacterium columnare against columnaris disease in fish
Safe and effective live vaccines against Flavobacterium columnare of fish were created through the induction of rifampicin resistance in a native Flavobacterium columnare isolate; these...
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6881411 |
Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
This invention satisfies needs in the art by providing intimin, the Enterohemorrhagic Escherichia coli (EHEC) adherence protein, alone or as a fusion protein with one or more other antigens,...
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6878858 |
Rodent model for Parkinson's Disease
The present invention provides an animal model for Parkinson's Disease and a method for generating such a model. The method comprises the steps of transfecting dopaminergic neurons in the...
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6878692 |
Apoptin-associating protein
The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work...
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6878515 |
Ultrasensitive immunoassays
The present invention relates to an immunological test kit and immunoassay using a first immobilized antibody having affinity for a specific antigen. The invention is characterized by a second and...
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6875749 |
Methods of facilitating vascular growth
A method of facilitating vascular growth in a subject in need of such treatment comprises inhibiting EMAP II activity in the subject by an amount effective to stimulate vascular growth in the...
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6875748 |
Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides...
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6875747 |
Antisense to c-myc for treatment of polycystic kidney disease
A method of treating polycystic kidney disease by administering an oligonucleotide antisense to c-myc is described. The antisense oligonucleotide is preferably a morpholino oligonucleotide.
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6875736 |
Methods for identifying RNA binding compounds
The present invention relates to methods of screening for compounds that bind RNA molecules. In particular, the methods of the invention comprise screening a library of test compounds, each of...
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6875584 |
Prophylactic and therapeutic immunization against protozoan infection and disease
Polypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided,...
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6875570 |
Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to...
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6872519 |
In vitro process for selecting phage resistant to blood inactivation
The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for...
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6869937 |
Acyl CoA:cholesterol acyltransferase (ACAT-2)
Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein...
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6869936 |
Means and methods for fibroblast-like or macrophage-like cell transduction
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one...
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6869935 |
Gene Therapy for proliferative vitreoretinopathy
A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a...
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6867349 |
Inhibition of gene expression using polynucleotide analogues
The invention provides sequence specific polynucleotide analogues and methods for determining the function of a nucleic acid of known sequence.
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