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7238675 |
Antisense antibacterial method and composition
The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use....
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7238674 |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of...
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7235236 |
Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function
The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart...
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7235534 |
Antisense strategy to modulate estrogen receptor response (ER α and/or ER β )
The present invention provides novel antisense oligonucleotides that target the genes and mRNAs encoding mammalian Estrogen Receptors (ER) alpha and/or beta and modulate the receptors' responses....
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7235233 |
Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts
The invention provides means and methods for transduction of a skeletal muscle cell and/or a muscle cell specific precursor thereof. Provided is the use of a gene delivery vehicle derived from an...
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7232682 |
Expression vectors encoding epitopes of target-associated antigens and methods for their design
The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing...
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7232806 |
MicroRNA molecules
In Caenorhabditis elegans , lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is...
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7232808 |
Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for MnSOD, and further provides methods of reducing expression of MnSOD in cells (e.g., cancer cells).
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7232807 |
Compositions and methods for binding agglomeration proteins
Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one...
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7229959 |
Supplemented fibrin matrix delivery systems
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
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7229974 |
G cap-stabilized oligonucleotides
Oligonucleotides of the formula
5′-(CAP)-(Oligo)-(CAP)-3′
are disclosed...
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7229975 |
DNA immunization against chlamydia infection
Nucleic acid, including DNA, immunization is used to generate a protective immune response in a host, including humans, to a serine-threonine kinase (STK) of a strain of Chlamydia . A...
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7229976 |
Modulation of forkhead box O1A expression
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7223600 |
Photochemical internalization for delivery of molecules into the cytosol
The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a...
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7223740 |
Vectors for enhanced expression of VEGF for atrial disease treatment
The invention provides a vector which is capable of the expression of a vascular endothelial growth factor wherein the vector comprises a modified PCMV promoter. The invention further provides use...
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7223739 |
Adjuvanted genetic vaccines
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
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7223742 |
Enhanced solubility of recombinant proteins
Disclosed are methods for improving the solubility of a protein of interest produced recombinantly by expressing the protein of interest as a fusion protein with a member of the 14-3-3 family of...
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7220575 |
Melanoma differentiation associated gene-5 and promoter and uses thereof
The invention provides for an isolated nucleic acid encoding Mda-5 (melanoma differentiation associated gene-5) and an isolated Mda-5 polypeptide. The invention further provides a vector comprising...
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7220728 |
Methods of inducing mucosal immunity
Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected...
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7217699 |
Compositions comprising genome segments and methods of using the same
Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, or preventing an individual...
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7217700 |
Chemokines as adjuvants of immune response
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating...
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7217571 |
Gene therapy by small fragment homologous replacement
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the...
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7214368 |
Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene
The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and...
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7211414 |
Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for...
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7211558 |
Compositions and methods for the treatment of hemophilia A
Improved materials and methods for the treatment of Hemophilia A are provided.
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7211569 |
Synthetic human papilloma virus genes
Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as...
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7208313 |
Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
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7208478 |
Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which...
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7208267 |
Compositions and methods relating to breast specific genes and proteins
The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids...
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7205280 |
Methods of suppressing microglial activation
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral...
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7204982 |
Compositions and methods for treatment and detection of multiple cancers
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate...
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7205283 |
Antisense oligonucleotides that inhibit expression of HIF-1
New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.
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7205282 |
Remedies for hepatitis
The object of the present invention is to provide a novel medicinal agent useful in the treatment or the prevention of hepatitis. The present invention is, for example, a therapeutic or preventive...
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7202228 |
Hydrogelation agents
A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or...
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7202226 |
Augmentation of wound healing by elF-4E mRNA and EGF mRNA
There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting...
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7201911 |
Cloned genomes of infectious hepatitis C viruses and uses thereof
The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the...
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7202225 |
Therapeutic delivery compositions and methods of use thereof
The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition...
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7201910 |
Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines
The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus....
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7202227 |
Multifunctional molecular complexes for gene transfer to cells
A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety...
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7196068 |
Method for treating cancer using p38/JTV-1 and method for screening pharmaceutical composition for treating cancer
The present invention relates to a method for treating cancer using p38/JTV-1 and a method for screening pharmaceutical composition for treating cancer. More particularly, this invention relates to...
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7196067 |
Antisense insulin-like growth factor binding protein (IGFBP)-2-oligodeoxynucleotides for prostate and other endocrine tumor therapy
Compositions and a method are provided for the treatment of prostate and other endocrine tumors in mammals, including humans, by administration of an antisense oligodeoxynucleotide (ODN) which is...
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7196070 |
Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The...
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7196069 |
High affinity RNA ligands of basic fibroblast growth factor
Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF...
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7196066 |
DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic...
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7192933 |
Use of a baculovirus to express an exogenous gene in a mammalian cell
Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a baculovirus whose genome carries an exogenous gene, and growing the cell under...
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7192579 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7192934 |
Vaccines for blocking transmission of Plasmodium vivax
The present invention relates to novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including...
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7192936 |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and...
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7192605 |
Nucleic acid transfer complexes
The present invention relates to compositions and methods for transferring nucleic acids into cells in vitro and in vivo. The compositions comprise a transfection reagent and one or more...
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7192935 |
Polynucleotides encoding epithelium-derived T-cell factor and uses thereof
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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