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7005423 |
Characterization of gene function using double stranded RNA inhibition
There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in...
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7005300 |
Polyhydroxy diamine surfactants and their use in gene transfer
The use of carbohydrate-based surfactant compounds having the general formula (I):
wherein Y 1 and Y 2 , which may be the same or different, are carbohydrate groups;
R 1 and R 2 , which may...
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7005140 |
Lipid particles having asymmetric lipid coating and method of preparing same
A method of preparing lipid particles having an asymmetric lipid coating is described. The lipid composition of the outer lipid coating of the particles varies from the inner to outer surfaces. The...
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7005139 |
Compositions and methods for the targeted delivery of agents to treat liver cancer
The invention provides compositions containing an effective amount of a therapeutic agent encapsulated in a liposome coupled to a desialyated glycoprotein, e.g., desialyated glycoprotein-α1. This...
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7005127 |
Mixed-cell gene therapy
The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a...
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7005126 |
Method for tumor treatment using infusion of xenogeneic cells to induce hyperacute rejection and innocent bystander effect
A method for treating tumors. Through infusion or xenotransplantation of xenogeneic cells, such as infusion of murine cells into the peritoneal cavity of humans, a hyperacute rejection response to...
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7001891 |
Biodegradable polycation composition for delivery of an anionic macromolecule
The present invention provides a biodegradable polycation composition for delivery of an anionic macromolecule, comprising a polysaccharide chain having an amount of saccharide units ranging from 2...
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7001890 |
Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination
The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable...
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7001760 |
Hepatitis B virus vectors for gene therapy
The present invention relates to novel hepatitis B virus vectors for use in gene therapy which can deliver therapeutic genes to liver cells. The invention also provides methods for the production...
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7001759 |
Compositions and methods for delivery of genetic material
Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an...
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6998268 |
Gene preparations
The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same. The carrier is preferably...
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6998254 |
Use of ROR for receptors for screening substances useful for the treatment of atherosclerosis
The subject of the present invention is the use of the ROR receptors and/or of their response element or alternatively of a functional equivalent thereof for the screening of substances having...
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6998117 |
Cancer treatment with retroviral vectors comprising wild-type p53
Disclosed are methods and compositions for the selective manipulation of gene expression through the preparation of retroviral expression vectors for expressing antisense sequences, such as K-ras...
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6995148 |
Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor...
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6995147 |
Method of delaying the onset of diabetes
A method for preventing, delaying the onset of or treating diabetes in a patient comprising selecting a patient who is susceptible to developing diabetes, who is developing diabetes or who is...
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6995146 |
Compositions and methods for treatment of hepatitis C virus-associated diseases
Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These...
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6995134 |
Use of yneS, essential bacterial genes and polypeptides
Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae , which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as...
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6994959 |
G-rich oligo aptamers and methods of modulating an immune response
Aptamer oligonucleotides specifically bind to the DNA binding site of proteins such as Sp1 and Sp1-related proteins which regulate the genes which encode costimulatory molecules such as CD28 and...
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6994870 |
Local nasal immunotherapy with allergen strip for allergic rhinitis
A method and strip for treating allergen-induced airway inflammation. The method includes applying a nasal or skin strip containing a mixture of an allergen and a pharmaceutically acceptable...
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6994851 |
Method of inducing a CTL response
A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained...
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6992070 |
Methods and compositions for nucleic acid delivery
The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions...
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6991901 |
Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to...
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6989375 |
Enhanced expression of transgenes
The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the...
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6989374 |
Gene therapy for cardiomyopathy
This invention enables the repair of cardiac function by noninvasive administration of an HGF gene in the form of Sendai virus (HVJ)-liposome into the affected cardiac muscle, thereby inducing...
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6989270 |
Using polyamide nucleic acid oligomers to engender a biological response
The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells...
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6989232 |
Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to...
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6987096 |
Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences,...
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6984379 |
Gene therapy by administration of genetically engineered CD34+ cells obtained from cord blood
A method of providing a therapeutic effect in a human patient which comprises administering to the patient CD34+ cells obtained from cord blood. The CD34+ cells have been engineered with at least...
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6982082 |
Gene therapy by cell specific targeting
This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating...
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6979677 |
Inhibition of vascular smooth muscle cell proliferation
A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured...
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6977245 |
Oligodeoxynucleotide and its use to induce an immune response
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula:
5′X 1 X 2 X 3 Pu 1 ...
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6977244 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The...
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6977164 |
Compositions and kits for Herpes Simplex Virus type 1 and 2 nucleic acid detection
The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection.
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6977074 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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6974671 |
Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
In accordance with the present invention, it has been discovered that CREB regulates hepatic gluconeogenesis via the co-activator, PGC-1. PGC-1 potentiated glucocorticoid induction of the gene for...
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6974668 |
Development of method for screening physiologically active pyrrole imidazole derivative
A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting...
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6969704 |
Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
The invention provides a method for reducing damage to an ischemic tissue which comprises contacting cells of the tissue with an inhibitor of Early Growth Response Factor-1 Protein (Egr-1). In...
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6969528 |
Phosphorus-containing dendrimers as transfection agents
The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or...
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6967091 |
OBG3 globular head and uses thereof for decreasing body mass
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight...
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6967076 |
Method for producing recombinant cells for detecting HIV
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6964951 |
Polynucleotide
The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The present invention also relates to a vector comprising...
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6964950 |
Antisense modulation of C-reactive protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense...
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6964849 |
Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to...
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6962906 |
Oligonucleotide analogues, methods of synthesis and methods of use
The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making...
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6962814 |
Decellularized tissue engineered constructs and tissues
New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a...
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6960570 |
Compositions and methods for the therapy and diagnosis of lung cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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6960569 |
Hepatitis C virus non-structural NS3/4A fusion gene
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the inevntion include HCV peptides, nucleic acids encoding said HCV peptides,...
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6958147 |
Use of VEGF-C to prevent restenosis
The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth...
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6956028 |
Compositions and methods for treatment of mitochondrial diseases
Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine...
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6953784 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
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