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7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7589120 |
N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application
The invention relates to compounds of formula (I):
Wherein X, R 1 , R 2 , R 3 and R 4 are as described herein. The invention also relates to a method for preparing the aforementioned...
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7589089 |
Inhibitors for GlyT-1
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , R 3 , R 4 , and X are as defined herein or to pharmaceutically acceptable acid addition salts thereof, with the...
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7586008 |
Propofol analogs, process for their preparation, and methods of use
The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such...
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7585865 |
Protein kinase C zeta inhibition to treat vascular permeability
Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of...
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7572817 |
2,5-disubstituted 3-mercaptopentanoic acid
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus...
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7553867 |
Furan or thiophene derivative and medicinal use thereof
The present invention provides a compound represented by the formula (I):
[wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or...
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7550135 |
Composition for external application
The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following...
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7547725 |
Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
Compounds of Formula (I),
are provided where T is CHO, COR 8 , or C(OH)R 1 R 2 ; R 1 and R 2 are hydrogen, optionally substituted lower alkyl, CF 3 , optionally substituted alkenyl, or...
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7541381 |
Non-covalent inhibitors of AmpC β-lactamase
β-lactamases are the most widespread resistance mechanism to β-lactam antibiotics, such as penicillins and cephalosporins. In response to these enzymes, inhibitors have been introduced....
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7528173 |
Plasma carboxypeptidase B inhibitors
Compounds of the following formula (I), for example: (1), wherein R 1 , R 2 , R 3 , and R 4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions...
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7517880 |
Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7504433 |
Thiophene derivative PPAR modulators
The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof,...
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7495024 |
Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
The method of treating patients be administering phenylalkyl N-hydroxurea derivatives for combating atherosclerotic plaque and cardiovascular diseases and compositions for this use.
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7495023 |
Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use
The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as...
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7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
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7482376 |
Conjugated complement cascade inhibitors
The present invention is directed to conjugated complement cascade inhibitors, and a method of treating a patient using a conjugated complement cascade inhibitor.
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7468437 |
Phenyl pyrrolidine ether tachykinin receptor antagonists
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7452914 |
Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more...
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7449490 |
Pharmaceutically active compounds and methods of use
New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of...
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7449481 |
Thio-substituted biaryl-methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
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7446219 |
N-acylaminoacetonitrile derivatives and their use for controlling parasites
The invention relates to compounds of the general formula
in which R 1 , R 2, R 3 , R 4 , R 5 , R 6 , W, X, A 1 , A 2 , a, b and c are as defined in the specification, and to any enantiomers...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7439372 |
Therapeutic compounds
A compound having a structure
is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
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7423170 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
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7423061 |
Substitute thiophenes and uses thereof
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7414071 |
Methods of treatment with selective EP4 receptor agonists
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the...
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7411093 |
Aminocycloalkanes as DPP-IV inhibitors
The present invention relates to compounds of formula (I)
wherein R 1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for...
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7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
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7396843 |
5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
Compounds of formula (I):
or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7393865 |
Sleep inducing compounds and methods relating thereto
Compounds having the following structure (I):
including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , L 1 , L 2 ...
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7388029 |
Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7368472 |
1,2,4-Triaminobenzene derivatives useful for treating disorders of the central nervous system
The present invention concerns 1,2,4-triaminobenzene derivatives of the general formula I or pharmaceutically acceptable salts thereof and the use thereof.
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7351725 |
N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
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7342042 |
Lily of the valley aromachemicals
Improved cyclamenaldehyde derivatives, and fragrances and flavorings including the derivatives, are disclosed. In particular, the derivatives maintain the fragrance characteristics of...
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7335673 |
2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage
A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts...
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7332518 |
Carboxamides as fungicides in agriculture
The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R 1 is CH 2 R 2 , CH 2 CH═CHR 2 , CH═C═CHR 2 or...
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7329686 |
Substituted thiophene compounds
There are provided novel compounds of formula (I) wherein R 1 , R 2 , R 3 , R 10 , M, Q, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together...
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7326695 |
Anti-bacterial agents based upon oxoanion binding
Compounds of the structure I:
are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T 1 and T 2 are each independently selected from...
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7319111 |
Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
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7317034 |
Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds
Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in...
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7294639 |
Biaromatic ligand activators of PPARγ receptors
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I):
and are well suited,...
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7291621 |
Substituted biaryl amides C5a receptor modulators
Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C 5 a receptor activity in vivo or in vitro, and are particularly useful in the...
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7276518 |
Substituted cyclohexane-1,4-diamine compounds
Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds.
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7271186 |
Nanomolar β-lactamase inhibitors
New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by...
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