Patents in Class 514/438

Matches 1 - 50 out of 718

Match	Document	Document Title
1	8183281	CXC-chemokine receptor ligands The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.
2	8158677	Treatment of viral infections by modulation of host cell metabolic pathways Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for...
3	8153667	Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
4	8138222	Whitening agents for cellulosic substrates This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one...
5	8119685	Disubstituted aniline compounds The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal...
6	8093253	Leukotriene B4 inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
7	8088804	N-hydroxyamide derivatives possessing antibacterial activity Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections...
8	8088819	Derivatives of substituted 3-phenyl-1-(phenylthienyl)propan-1-ones and of 3-phenyl-1-(phenylfuranyl) propan-1-ones, preparation and use The present invention relates to compounds derived from substituted 3-phenyl-1-(thien-2-yl)propan-1-ones, pharmaceutical compositions comprising them as well as their therapeutic applications,...
9	8084452	Substituted enaminocarbonyl compounds used as insecticides The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in...
10	8063067	Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
11	8053439	Benzophenone derivatives useful for inhibiting formation of microtubule Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition...
12	8039493	Biaryl sulfonamide derivatives The invention is concerned with novel biaryl sulfonamide derivatives of formula (I) wherein R1 to R3 and Y are as defined in the description and in the claims, as well as physiologically acceptable...
13	8026275	Compositions, methods of use and preparation of 2,6-diisopropyl phenol and analogs for ischemic injury The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and...
14	8022100	Whitening agents for cellulosic substrates This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one...
15	8017558	Carboxamides for controlling micro-organisms in plant and material protection Novel carboxamides of the formula (I) The present application is further directed toward a plurality of processes for preparing these compounds and their use for controlling unwanted...
16	8003680	Therapeutic compounds Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
17	7998965	Glutamate aggrecanase inhibitors The present invention relates to modulators of metalloproteinase activity.
18	7985767	Therapeutic amides Compounds of the formula are disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
19	7981907	Thio-substituted biarylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
20	7981874	Phosphorus derivatives as histone deacetylase inhibitors The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are...
21	7977374	Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof. The compounds of the present invention are inhibitors of histone...
22	7977370	(Hetero)aryl cyclohexane derivatives The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these ...
23	7951806	Plasminogen activator inhibitor-1 inhibitor The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1...
24	7951837	Crystalline forms of duloxetine free base The present invention is concerned with duloxetine free base in crystalline form, and also novel polymorphic forms thereof.
25	7935696	Heterocyclic amide compounds useful as kinase inhibitors A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods...
26	7928129	Nanomolar β-lactamase inhibitors New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by ...
27	7906552	Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or...
28	7872041	Use of rotigotine for treating and preventing Parkinson's plus syndrome The invention relates to the use of rotigotine, its salts and prodrugs, as a medicament for preventing and/or treating Parkinson's plus syndrome.
29	7863319	Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof,having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or...
30	7863318	Prostaglandins and analogues as agents for lowering intraocular pressure The present invention relates to cyclopentane heptenoic acid-5-cis-2-(3α-hydroxy or lower alkyloxy-5-thienylpentyl)-3, 5-dihydroxy, [1α, 2β, 3α, 5α] compounds, lower alkyl, hydroxyl lower alky...
31	7858658	Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted...
32	7855232	Organoselenium compound for cancer chemoprevention A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be...
33	7851501	Aromatic nitrocatechol compounds and their use for modulating processes mediated by cell adhesion molecules Pharmaceutical compositions comprising at least one compound of e.g. the formulas (Ie) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents...
34	7842717	DNT-maleate and methods of preparation thereof (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanam ine maleate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation...
35	7838020	Cosmetic or dermatological composition comprising an association between a compound of the N-acylaminoamide family and at least one matrix metalloproteinase inhibitor A cosmetic or dermatological composition characterized in that it comprises an association between an elastase inhibitor compound of the N-acylaminoamide family and at least one metalloproteinase...
36	7834013	Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates...
37	7825154	Small molecule inhibitors of botulinum neurotoxins Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or...
38	7803798	Therapeutic compounds Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, B, D, and Y are as described. Methods, compositions, and medicaments related thereto are...
39	7803797	Substituted arylcyclopentenes as therapeutic agents Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are...
40	7795315	N-(2-amino-phenyl)-amide derivatives The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments...
41	7790758	Compounds which potentiate glutamate receptor and uses thereof in medicine This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I): The invention also relates to the use of the derivatives in treating diseases and conditions...
42	7776922	Substituted [(phenylethanoyl)amino]benzamides The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of...
43	7749990	Compositions for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
44	7745445	Compounds and compositions as PPAR modulators The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of...
45	7745456	Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the...
46	7741323	Indene derivatives and process for the preparation thereof An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or...
47	7732483	DNA-PK inhibitors A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7...
48	7709507	Therapeutic fluoroethyl ureas Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.
49	7705043	Substituted aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the...
50	7691898	Phosphonic acid derivatives and the treating agents of diseases related hyperphosphatemia This invention related to a series of new phosphonic acid derivatives having anti-hyperphosphatemia activity. wherein: A is selected from —(CH2)n—, —CO—, —(CH2)n—CO—(CH2)m—, —(CH2)n—CS—(CH2...

Matches 1 - 50 out of 718

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