Patents in Class 514/437

Matches 1 - 50 out of 89

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Match	Document	Document Title
1	7589083	Compounds and compositions to control abnormal cell growth A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class,...
2	7576094	Spiro derivatives as lipoxygenase inhibitors The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating...
3	7482344	Tricyclic steroid hormone nuclear receptor modulators The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in...
4	7423029	Compounds to promote regeneration of bone marrow Embodiments of the present invention include the use of heterocyclic trialkyl ammonium-containing compounds to promote regeneration of bone marrow from endogenous or exogenous stem/progenitor cells...
5	7288560	Spirocyclic cyclohexane derivatives The present invention relates to spirocyclic cyclohexane compounds, to methods for their production, to pharmaceutical compositions containing these compounds, to methods of treatment using such...
6	7268148	Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen...
7	7238725	Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes.
8	7223774	Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
9	7115605	Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided.
10	7105569	Fungicidal active compound combinations New active compound combinations of valinamide derivatives of the formula (I) in which R 1 and R 2 has the meaning given in the description, with known fungicidal active substances,...
11	7019024	Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
12	6825226	Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for...
13	6806283	Selective serotonin receptor antagonists and therapeutic applications thereof Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of...
14	6784202	Cubane derivatives as metabotropic glutamate receptor agonists or antagonists and process for their preparation The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful...
15	6767919	High specificity anticancer agents A process for producing new anticancer drugs such that the drugs can be administered in a nontoxic, proto-drug form and, subsequent to a time delay which allows for differential concentration in...
16	6730697	Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid Dihydrothiaphenanthrenecarbonylguanidine compound of formula I These compounds are potentially suitable as antiarrythmic medicaments with a cardioprotective component for prophylaxis of an...
17	6693136	Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) are novel P2X 3 and P2X 2 /P2X 3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.
18	6620834	Medicinal compositions for treating colorectal cancer Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a...
19	6613797	Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as...
20	6602903	Substituted heterocyclic compounds The invention relates to compounds of formula (I): and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
21	6566389	Therapeutic uses of melatonin A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
22	6521641	Male anti-fertility agents Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.
23	6514967	Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): in which: R 1 and R 2 represent a hydrogen atom, or form a ring, especially a benzene ring, R 3 represents a hydrogen...
24	6511968	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis,...
25	6391911	Coadministration of lucanthone and radiation for treatment of cancer Disclosed is a method of treating a cancer of the central nervous system in a host including administering radiation to the host; and administering lucanthone to the host; wherein the radiation and...
26	6384045	Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone...
27	6258836	Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be...
28	6245797	Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease The instant invention provides a drug combination comprised of an HMG-CoA reductase inhibitor in combination with a COX-2 inhibitor, which is useful for treating, preventing, and/or reducing the...
29	6172058	Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R 1 is C 1 -10 alkyl, C 2 -10 alkenyl, C 2 -10 alkynyl, C 3 -10 cycloalkyl, C 3 -10 cycloalkyl-C 1 -10 alkyl, C 3 -10 cycloalkyl-C 2 -10...
30	6117869	Compounds for and methods of inhibiting matrix metalloproteinases The present invention relates to compounds of Formula I that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds ##STR1## More...
31	6100253	Tricycle substituted with azaheterocyclic carboxylic acids The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R 1 , R 2 and r are as defined in the detailed part of the present...
32	6054448	2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R 1 is Y or Y--C 1 -6 alkyl, where Y is carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or...
33	5994392	Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be...
34	5990104	Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R 1 is H, C 1 -6 alkyl, or C 6 -12 aryl optionally substituted with polar groups; R 2 and R 3 are independently H, OH, C 1 -6 alkyl, --C(NH)--NH 2 ,...
35	5977077	Xanthone analogs for the treatment of infectious diseases Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also...
36	5891899	Pharmaceutical xanthene compounds A pharmaceutical compound of the formula: ##STR1## in which A is carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OPO(OH)OR' B is a bond, C 1 -6...
37	5880146	Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or...
38	5827856	Method of treating insulin resistance The present invention provides a novel method for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting...
39	5726208	Heterocyclic tertiary amines New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers, and their addition salts with...
40	5665760	Lyophilized thioxanthenone antitumor agents Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a...
41	5571825	Method of selectively inhibiting prostaglandin G/H synthase-2 The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a...
42	5550110	Endothelin Antagonists II Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute...
43	5447960	Fungicidal use of phenolic aromatic compounds A plant fungicide method comprises applying to the locus of a plant pathogen a fungicidally effective amount of a compound of formula (I) ##STR1## or a salt or a complex thereof, wherein: R 1 , R 2...
44	5438056	Heterocyclic oxime carbamates The compounds of the present invention have the following formula: ##STR1## wherein R 1 and R 2 are independently phenyl, pyridyl, thienyl, naphthyl, substituted phenyl wherein the substituent is...
45	5380749	Thioxanthenone antitumor agents 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-o nes are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals...
46	5276053	Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
47	5196445	Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R 4 )--, --O--CH(R 4 )--, --S(O) n --CH(R 4 )--, --CH(R 4 )--O--, --CH(R 4 )--S(O)...
48	5192765	Certain amines which are muscarinic receptor antagonists Amines of the following formula: ##STR1## where the variables are defined in the specification are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle.
49	5104858	Sensitizing multidrug resistant cells to antitumor agents A method for sensitizing multidrug resistant cells to antitumor agents comprosing contacting multidrug resistant cells, with an effective amount of a compound of the formula ##STR1## wherein n is...
50	5071853	Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...

Matches 1 - 50 out of 89

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