Matches 151 - 200 out of 307 < 1 2 3 4 5 6 7 >
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5512568 Method of using 4-amino derivatives of 5-substituted mycophenolic acid  
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other...
5506242 Arylsufonamido-substituted hydroxamic acids  
The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which...
5506257 Aminocyclohexylamides for antiarrhythmic and anaesthetic uses  
The present invention provides methods for blocking sodium channels in cardiac or neuronal tissue using aminocyclohexylamides. This invention also provides kits including aminocyclohexylamides and...
5502053 HIV protease inhibitor compounds  
Compounds of formula ##STR1## are HIV protease inhibitors, and are synthesized via a novel route. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment...
5502061 Peptidyl substituted benzamides and naphthamies  
The present invention provides HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
5491152 Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis  
The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT),...
5484810 Tissue protective tocopherol analogs  
This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and...
5484805 Heterocyclene derivatives  
The invention concerns a heterocyclene derivative of the formula I ##STR1## wherein Ar 1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety; A 1 is...
5482966 Oxime derivatives  
The invention concerns oxime derivatives of the formula I ##STR1## wherein R 4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and...
5462965 Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases  
A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with...
5441722 Short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C.sup.3 H.sub.3 ]-4[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non radioactive compounds  
This invention concerns the short synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-[C 3 H 3 ]-4H-thieno [2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related non-radioactive and radioactive...
5428027 Substituted semicarbazone arthropodicieds  
Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.
5428061 Organic nitrates and method for their preparation  
New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide, which prevent nitrate tolerance or overcome existing tolerance and which...
5426109 Phenylnaphthalene hydroxy acids  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5403857 Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory activity  
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R 1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R 2 and R 3 together form -A 2 -X 2 -A 3 - which...
5399584 Use of flavone derivatives for gastroprotection  
The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective...
5399561 Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity  
Compounds of the formula ##STR1## where R 1 and R 2 are hydrogen, lower alkyl of 1-6 carbons, or halogen; R 3 is hydrogen, lower alkyl of 1-6 carbons, halogen, OR 11 , SR 11 , OCOR 11 , SCOR 11...
5399589 Oxalyl hydrazide-hydroxamic acid derivatives, their preparation and their use as fungicides  
Oxalyl hydrazide-hydroxamic acid derivatives of the formula I ##STR1## where the substituents have the following meanings: R, R 1 , R 2 and R 3 independently of one another are hydrogen,...
5382572 Alkyl and acyl substituted quinolines  
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically...
5378694 Acyl and alkoxy substituted quinolines  
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1.0: ##STR1## and their...
5360815 Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5348976 Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same  
The present invention provides a condensed heterocyclic derivative represented by a formula: ##STR1## wherein R 1 represents a lower alkyl group, an alkenyl group, or the like, R 2 , R 3 , R 4 , R...
5346915 Chromans and thiochromans with phenylethynyl substituents at the 7-position having retinold-like biological activity  
Novel compounds of the formula ##STR1## where X is S, O; R 1 -R 5 are hydrogen or lower alkyl; R 6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower...
5346895 Chromans and thiochromans with heteroarylethynyl substituents at the 7-position having retinoid-like biological activity  
Novel compounds of the formula ##STR1## where X is S, O; R 1 -R 5 are hydrogen or lower alkyl; R 6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower...
5314891 Benzenesulphonamide derivatives  
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R 1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R 2 and R 3 together form --A 2 --X 2 --A 3 --...
5308863 Substituted aromatic sulfonamides as antiglaucoma agents  
Thieno[2,3-b]thiopyran-2-sulfonamides and ring homologs with a hydrophilic substituted-alkyl group adjacent to the thiopyran sulfur are carbonic anhydrase inhibitors topically effective in lowering...
5292768 Compound effective as cerebral insufficiency improver  
A compound having the formula (I): ##STR1## wherein A is --CH 2 --, --O--, or --S--; R 1 is CH 3 or OCH 3 ; R 2 is hydroxy or carboxy which may be optionally esterized or amidated; R 3 is H...
5278174 Sigma binding site agents  
Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these...
5276053 Polycyclic amines useful as cerebrovascular agents  
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
5252608 Inhibitors of lysyl oxidase  
This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
5246961 β-d-phenylthioxylosides, and their use as therapeutic agents  
The present invention relates, by way of novel industrial products, to the β-D-phenylthioxyloside compounds of the formula ##STR1## in which: X represents a sulfur atom or an oxygen atom; R 1 ,...
5227399 Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5208222 4"-and 4'-alkylthio avermectin derivatives  
Avermectin derivatives are disclosed wherein the 4"-hydroxy group is replaced by a substituted alkylthio or acylthio group or an iodo group. These avermectin derivatives can be further derivatized...
5200410 Medicaments for the treatment of cerebral apoplexy  
A method of treating cerebral apoplexy in a patient in need thereof which comprises administering to said patient an amount effective therefor of a serotonin agonist which has a binding strength of...
5190956 Certain N-substituted 3-oximino-2,4-dioxoquinolin-2,4-(1H)diones useful for treating viral infections  
Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their...
5180735 Cyclohexanol derivatives, production and use thereof  
The present invention relates to a compound of the formula: ##STR1## wherein A is halogen, N(O)mR 1 R 2 , N ♁ R 1 R 2 R 3 X .crclbar ., S(O)nR 1 or S ♁ (O)mR 1 R 2 X .crclbar . ...
5166161 1,3-dicarbonyl compounds and their use  
3-Oxo-4-acyl or carbamyl-bicyclic aromatic and heterocyclic compounds as inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergy and antiinflammatory agents.
5145855 6- and 7-deoxyforskolin and derivatives thereof  
Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are...
5128348 Bicyclo(3.1.0)hexane amines and bicyclo(4.1.0)-heptane amines as agricultural fungicides  
Certain hexane and heptane amines including geometric and stereoisomers, agricultural compositions containing them and their use as fungicides.
5116874 Anti-tumor method and compounds  
This invention provides certain N-[(phenyl)amino]carbonyl-bicyclicsulfonamide sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in...
5100913 Novel sulfonylphenyl-β-D-thioxylosides, their method of preparation and their use in therapeutics  
The present invention relates, by way of novel industrial products, to the sulfonylphenyl-β-D-thioxyloside compounds of the formula ##STR1## in which: X is a sulfur atom or an oxygen atom; R is...
5093356 Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase  
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5091409 4-alkylamino-6-(C.sub.3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides  
4-Alkylamino-6-(C 3 -5 -hydrocarbyl)thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxid es wherein the 4-alkylamino group is an ethylamino or propylamino are powerful carbonic anhydrase inhibitors...
5071841 Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production  
The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon...
5071853 Polycyclic amines useful as cerebrovascular agents  
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
5071871 Pharmaceutically useful benzo(β)pyranes and pyranopyridines  
New benz[b]pyranes and pyranopyridines of formula I, ##STR1## wherein the significances of substituents V, T, W, R 3 to R 5 , R 9 , R 10 , m, X, Y and Z are given in claim 1 and their N-oxides and...
5059621 Aromatic heterocyclic derivatives and their thereapeutic and cosmetic use  
An aromatic heterocyclic compound has the formula ##STR1## wherein R 1 represents (i) --CH 3 , (ii) --CH 2 OH or (iii) ##STR2## wherein R 3 represents hydrogen, --OR 4 wherein R 4 represents...
5047419 Photodynamic therapy of glioma or mammary carcinoma using seleno- or telluropyrylium salts  
There are disclosed pyrylium salts and a method of using them medicinally in photodynamic therapy for increasing the survival time of animals affected with glioma or mammary carcinoma. The salts...
5045561 Substituted furan sulfonamides as antiglaucoma agents  
Furan sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
5021458 Amine derivatives and fungicides containing the same  
Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as...
Matches 151 - 200 out of 307 < 1 2 3 4 5 6 7 >