Patents in Class 514/43

Matches 1 - 50 out of 356

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Match	Document	Document Title
1	7618949	Drug-eluting stents coated with P2Y₁₂receptor antagonist compound The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
2	7615536	1,4-benzothiazepine 1,1-dioxide derivative, process for its preparation, medicaments comprising this compound, and use thereof as a hypolipidaemic The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic
3	7608602	Gemcitabine prodrugs, pharmaceutical compositions and uses thereof The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and...
4	7608599	Antiviral phosphoramidates The invention provides novel nucleoside compounds of formula I wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5 R 6 , R 8a , R 9 and R 10 are as defined herein which are useful for the treatment of...
5	7608597	Methods and compositions for treating hepatitis C virus A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
6	7605137	Combination therapy comprising cloretazine This invention provides a method for treating tumor in a subject comprising administering to the subject an effective amount of: (1) VNP40101M, or its equivalent; and (2) a nucleoside, or a...
7	7601735	Antiviral compounds Use of certain castanospermine esters in the treatment of diseases caused by flaviviruses, in particular in the treatment of disease caused by the hepatitis C virus (HCV) and compositions...
8	7601701	Compounds for the treatment of tobacco dependence and withdrawal The invention provides methods for treating or suppressing tobacco or nicotine usage or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or...
9	7589079	Crystalline and amorphous forms of beta-L-2′-deoxythymidine Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns,...
10	7589068	Inhibitors of Akt activity The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for...
11	7582618	2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery,...
12	7582616	Nucleoside transport inhibitors Compounds or compositions that are inhibitors and/or ligands of nucleoside transporters; and methods of treating cancer, heart disease and stroke, as well as AIDS and other infectious diseases.
13	7579325	Drugs containing reduced of vitamin B₂ The present invention provides medicines for preventing or treating infectious diseases, sepsis and/or septic shock, which exhibit excellent immunostimulating effects. More specifically, the...
14	7576069	2-polycyclic propynyl adenosine analogs having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R 1 , R 2 , R 7 and Z are as described herein.
15	7576068	Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention...
16	7569555	Method for stimulating the immune, inflammatory or neuroprotective response Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune...
17	7566781	Imidazopyridine compound The present invention provides an imidazopyridine compound represented by formula (I), wherein R 1 and R 2 each independently represent a C 1-6 alkyl group et al; R 3 and R 4 each...
18	7563774	Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
19	7560436	Methods of treating gastrointestinal inflammation The present invention provides methods of treating gastrointestinal inflammation, methods of treating inflammatory bowel disease, methods of treating Crohn's Disease, and methods of treating...
20	7560435	Therapeutic use of riboside of 5-aminoimidazole-4-carboxamide (acadesine) The present disclosure relates to a method of treatment of a human patient suffering from a B-cell lymphoproliferative disorders such as B-cell chronic lymphocytic leukemia (B-CLL), splenic...
21	7557093	Composition for promoting collagen production The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the...
22	7557092	Purinergic modulation of smell Disclosed are compositions and methods for modulating odor sensitivity, as well as screening methods for detecting compounds that modulate odor sensitivity.
23	7547684	5′-modified bicyclic nucleic acid analogs The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside...
24	7547680	Benzimidazole derivatives and medical uses thereof The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory...
25	7538094	Composition containing ribavirin and use thereof Ribavirin formulations are disclosed for use in capsules or tablets as well as processes for their preparation and methods for their administration.
26	7534771	Tricyclic-nucleoside prodrugs for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
27	7528115	Carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidines The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to...
28	7524831	Treatments for Flaviviridae virus infection The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
29	7524825	Tricyclic-nucleoside compounds for treating viral infections Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
30	7510710	Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
31	7470784	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin -6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose;...
32	7462604	Hair growth promotor composition A hair growth promotor which is an ethanol or aqueous ethanol preparation comprising, as active ingredients for a hair growth promotor, (A) at least one compound selected from fatty acids having a...
33	7456155	2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery,...
34	7452870	Drug-eluting stents coated with P2Y₁₂receptor antagonist compound The present invention provides a P2Y 12 receptor antagonist compound-eluting stent, wherein the stent is coated with one or more P2Y 12 receptor antagonist compounds or a pharmaceutically...
35	7449570	Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering...
36	7445794	Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2)...
37	7439271	Reduction of hair growth Mammalian hair growth is reduced by applying an inhibitor of telomerase to the skin.
38	7435724	Degradation-resistant mononucleoside phosphate compounds The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that...
39	7429571	Therapeutic furopyrimidines and thienopyrimidines The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are...
40	7429569	Compositions and methods for the regulation of homocysteine levels within the body Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that...
41	7427672	Artificial nucleic acids of n-o bond crosslinkage type An oligonucleotide analogue useful for the antisense method, etc., having excellent enzyme resistance, having potent selective binding affinity for single-stranded RNA, and further having an...
42	7419963	Indole antiviral compositions and methods The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related...
43	7414031	5-nitro-nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
44	7405204	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
45	7399845	6-modified bicyclic nucleic acid analogs The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R)...
46	7399754	N²-quinoline or isoquinoline substituted purine derivatives Novel compound having the following formula: wherein W represents a hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or an optionally substituted C...
47	7399749	Substituted prolines as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
48	7396825	Agonists of A2A adenosine receptors for treatment of diabetic nephropathy The present invention provides a therapeutic method for treating diabetic kidney disease, e.g., diabetic nephropathy that includes the administration of an effective amount of an A 2A adenosine...
49	7393839	Polymorphic antiviral nucleoside compounds The present invention relates to the polymorphic crystalline hydrochloride salts of a nucleoside valinate ester according to formula Ib, methods of treating diseases mediated by Hepatitis C Virus...
50	7378401	Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases The present invention is directed to the systemic administration of Fosfluridine Tidoxil, (5-fluorouridine)-5′-phosphoric acid (3-dodecylmercapto-2-decyloxy)propylester or a salt thereof, for the...

Matches 1 - 50 out of 356

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