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9040498 1,2,3-Triazolyl purine derivatives  
The present invention relates to novel 1,2,3-triazolyl purine derivatives. The invention also relates to using the derivatives to treat cancer and various viral infections. An example of a...
9040501 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
9040490 Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation  
A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases...
9029335 Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom  
Provided herein are novel bicyclic nucleosides, oligomeric compounds that include such bicyclic nucleosides and methods of using the oligomeric compounds. More particularly, the novel bicyclic...
9029346 Irreversible inhibitors of DNA polymerase beta  
Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.
9029345 Selective inhibitors of translesion DNA replication  
An agent for inhibiting P-glycoproteins comprises a non-natural adenine ribose analog.
9029413 Treatment of viral infections by modulation of host cell metabolic pathways  
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets...
9023816 Bioactive alkaloid compositions and their medical uses  
The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such...
9018176 Inducers of hematopoiesis and fetal globin production for treatment of cytopenias and hemoglobin disorders  
The present invention generally relates to compositions containing chemical compounds and compositions and pharmaceutical formulations of the compounds which increase the expression of total...
9012427 Pharmaceutical combinations comprising a thionucleotide analog  
Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases...
9012428 Uracyl spirooxetane nucleoside phosphoramidates  
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate useful in the treatment of patients infected with the hepatitis C virus (HCV).
9006209 Uracyl spirooxetane nucleoside phosphoramidates  
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate which inhibits the hepatitis C virus (HCV).
9006208 Agent for treatment of dry eye characterized by combining P2Y2 receptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the P2Y2 receptor agonist and hyaluronic acid or salt thereof  
An agent for treatment of dry eye comprising a combination of a P2Y2 receptor agonist at a therapeutically effective concentration and hyaluronic acid or a salt thereof at a therapeutically...
9006194 Compositions and methods for diminishing viral infection and inflammation associated with viral infection  
The invention relates to compositions and methods for preventing and diminishing virus infection. The invention further relates to compositions and methods for diminishing inflammation associated...
8993527 Methods, compositions, and formulations for preventing or reducing adverse effects in a patient  
The present invention provides methods, compositions, formulations, and kits related to acadesine, or a prodrug, analog, or salt thereof, and/or a blood clotting inhibitor for preventing or...
8993528 Oligomeric compounds comprising tricyclic nucelosides and methods for their use  
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided...
8980850 Administration of a NEDD8-activating enzyme inhibitor and hypomethylating agent  
The present disclosure relates to methods for the treatment of cancer in patients in recognized need of such treatment. The methods comprise administering to such a patient an NAE inhibitor or a...
8975247 Methods and compositions of treating a flaviviridae family viral infection  
Clemizole and clemizole analog compounds, and pharmaceutical compositions of the same, are useful in methods of treating a host infected with a virus from the Flaviviridae family of viruses,...
8975239 Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine  
A first aspect of the invention relates to a combination comprising a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-β-D-arabino-pentofuranosyl)-N4-palmitoy l cytosine, or a metabolite...
8969313 Methods and compounds for preventing and treating a tumour  
The invention relates to a method of preventing, inhibiting, arresting or reversing tumorigenesis in a cell as well as a method of inducing apoptosis in a tumor cell. The method includes...
8969357 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8957046 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8951985 Compounds and pharmaceutical compositions for the treatment of viral infections  
Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are...
8946189 Transplants  
The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell,...
8946188 Anti-microbial agents and uses thereof  
Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III)...
8940707 Maribavir isomers, compositions, methods of making and methods of using  
The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for...
8927520 Antibacterial compounds  
The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of...
8916536 Bone-targeting bisphosphonate duplex drugs  
The present invention relates to novel bisphosphonate duplex drugs, methods for preparing said compound; pharmaceutical compositions containing the same; as well as the use of said compounds in...
8916538 Solid forms of a thiophosphoramidate nucleotide prodrug  
The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl) ethyl)thiophosphoramidate, pharmaceutical...
8916535 Use of 2′,5′-oligoadenylate derivative compounds  
The invention relates to the therapeutic uses of 2′,5′-oligoadenylate derivative compounds, more particularly for the treatment of chronic fatigue syndrome (CFS) and in the treatment of infection...
8916528 Compositions containing resveratrol and nucleotides  
A resveratrol-containing composition capable of providing a therapeutic benefit to a subject such as modulation of a biological activity, improving cell transplantation therapy, or improving...
8912162 Parenteral formulations of elacytarabine derivatives  
The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 1-β-D-arabinofuranosylcytosine (cytarabine). In particular,...
8906879 Combination for the treatment of cancer  
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method...
8906869 Effective treatment of ovarian cancer using triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only...
8906880 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8900565 Indole derivatives as inhibitors of histone deacetylase  
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using...
8900566 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8901092 Functionalized polysaccharides for active agent delivery  
Embodiments of the invention include functionalized polysaccharides and compositions and structures including the same. In an embodiment, the invention includes an active agent delivery...
8901086 Compositions including triciribine and methods of use thereof  
This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates...
8895520 Method for treating a human patent suffering from Myeloid Neoplasias using 5-aminoimidazole-4-carboxamide  
A method of treatment of a human patient suffering from myeloid neoplasias, includes administrating a therapeutically effective amount of 5-aminoimidazole-4-carboxamide (acadesine), acadesine...
8889791 Thermoresponsive, biodegradable, elastomeric material  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room...
8883135 Crystalline form of a pyridyl-piperazinyl hepatitis C virus inhibitor  
The invention provides crystalline solid forms of (((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarb amoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluo romethoxy-biphenyl-4-yl)-...
8871735 Methods and compositions for providing cardiac protection  
The invention provides a method of reducing infarct size and/or limiting, decreasing and/or inhibiting reperfusion injury and/or ameliorating heart failure in a patient comprising administering a...
8865666 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the...
8858939 Ectopic pregnancy treatment  
The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method...
8859502 Therapy for MLL-rearranged leukemia  
Provided are methods for treating MLL-rearranged ALL by administering to a patient an HDAC inhibitor alone or in combination with a DNA demethylating agent. Also provided are methods of treating...
8859512 Anti-viral pyrimidine nucleoside derivatives  
A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula...
8859513 Use of 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide for the treatment of infectious salmon anemia  
The invention relates to the novel use of 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide for the treatment of infectious salmon anaemia caused by the infectious salmon anaemia or ISA virus...
8853176 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8846628 Oral formulations of cytidine analogs and methods of use thereof  
The present disclosure provides pharmaceutical compositions comprising cytidine analogs, for example, 5-azacytidine or decitabine, for oral administration, wherein the compositions release the...