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7615566 |
Substituted pyrrolidine and related compounds
This invention is directed to compounds of formula I:
wherein R 1 -R 5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The...
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7608637 |
Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP 4 agonist as an active ingredient. An EP...
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7589119 |
Methods for treating or preventing metastatic cancer using benzopyranone compounds
This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
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7582653 |
Mercaptophenyl naphthyl methane compounds and synthesis thereof
Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications...
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7563789 |
1-Adamantyl chalcones for the treatment of proliferative disorders
The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of...
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7557137 |
Gamma-lactams as beta-secretase inhibitors
There is provided a series of novel substituted gamma-lactams of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, their pharmaceutical compositions and methods of use....
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7557126 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, e, m, n, Ar 1 , R 1 , R 2 , R 3 , R 4a , R 4b , R 5 and R 6 are as defined in the specification. The compounds of formula...
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7544716 |
Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
This invention relates to tetrahydro-naphthalene derivatives of formula (I)
in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms...
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7528156 |
Compounds
The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation,...
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7524880 |
Crystalline form of a substituted pyrrolidine compound
The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of 2-[(S)-1-(8-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylac
etamide or a solvate thereof. This invention also provides...
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7504431 |
Sulfonyl amide inhibitors of calcium channel function
Compounds of formula I
its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7470718 |
Method for treating a demyelinating condition
Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca 2+ -channel...
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7456209 |
IAP binding compounds
IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in...
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7446125 |
Derivatives of nitroproline compounds, processes of manufacture and uses in the treatment of integrin mediated disorders
This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also...
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7419936 |
Optically active 2,5-bisaryl-Δ1-pyrrolines and their use as pest control agents
Novel optically active Δ 1 -pyrrolines of the formula (I)
in which
R 1 , R 2 , R 3 , R 4 , and m are each as defined in the description, a plurality of the processes for preparing these...
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7417062 |
Substituted arylamides
Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
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7402684 |
Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation
The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of...
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7399748 |
Antitumor therapy comprising distamycin derivatives
The present invention relates to an administration schedule comprising the intravenous administration of a α-halogen-acryloyl distamycin derivative, or a pharmaceutically acceptable salt thereof....
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7396854 |
Use of serotonergic compound for a method of treatment of hot flushes in post-menopausal women
The present invention relates to a method of treatment of hot flushes with a 5-HT 2C receptor agonist and in particular to the use of the selective 5-HT 2C receptor agonists...
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7393864 |
Use of ClC3 chloride channel blockers to modulate vascular tone
The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking...
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7381742 |
Optically active polymaleimide derivatives and process for their production
Optically active maleimide derivatives of the formula:
(where the various substituents are as defined in the description) are used as separating media for separating optical isomers and...
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7358274 |
Methods for treating or preventing cancer using Benzopyranone Compounds
This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
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7351719 |
Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
The present invention relates to amide compounds of general formula I
wherein the groups and residues A, B, b, W, X, Y, Z, R 1 , R 2 and R 3 have the meanings given in claim 1 . Moreover the...
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7351718 |
Substituted pyrrolidine and related compounds
This invention is directed to compounds of formula I:
wherein R 1 -R 5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof....
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7348356 |
Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
Disclosed are compounds of formula (I)
which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is...
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7335681 |
Amino ceramide-like compounds and therapeutic methods of use
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of...
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7335680 |
Pyrrolidine derivatives as prostaglandin modulators
Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful...
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7335659 |
Substituted 10-aryl-11H-benzo[b]fluorenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors
This invention provides a compound, or its possible salt, having the formula,
wherein: R e and ′R e are OH, optionally independently etherified or esterified; Z is —CH 2 CH 2 — or...
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7323490 |
Pyrrole compounds and uses thereof
The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The...
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7288566 |
N-hydroxyformamidine derivatives
An N-hydroxyformamidine compound of the following formula or a pharmaceutically acceptable salt thereof:
wherein R 1 , A and R are as defined herein. The compounds inhibit 20-HETE-producing...
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7279472 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune...
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7255984 |
Combination therapy for osteoporosis
Pharmaceutical combination compositions including certain estrogen agonists/antagonists and prostaglandins or prostaglandin agonists/antagonists. The compositions are useful for the treatment of...
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7250415 |
1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors
The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives...
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7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
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7226917 |
Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia
Compounds of formula (I) as defined herein:
are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form)...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214714 |
20-hydroxyeicosatetraenoic acid production inhibitors
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof
[wherein R 1 represents a substituted morpholino group, a substituted...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7202269 |
GlyT2 modulators
Certain α-, β-, and γ-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus,...
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RE39558 |
5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis
Compounds of this formula
are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
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7199158 |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula:
wherein R 1 –R 6 , R 7 , R 7′ , R 8 , R 30 –R 34 , X′, Y, Y′, t, x, and n are as defined herein, are...
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7189758 |
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
A compound of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
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7186750 |
Optically active maleimide derivatives, optically active polymaleimide derivatives, process for their production, separating media comprising the optically active polymaleimide derivatives and method of separating optically active compounds using them
Optically active maleimide derivatives of the formula:
(where the various substituents are as defined in the description) are used as separating media for separating optical isomers and...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7169768 |
Method of decreasing atherosclerosis and its complications
A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
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7166601 |
Substituted diamine derivatives useful as motilin antagonists
The present invention relates to novel substituted diamine derivatives for the formula
wherein R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , A, Y and n are as described in the...
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7151115 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, e, m, R 1 , R 2 , R 3 , R 4a , R 4b , R 5 , R 6 , R 7 and R 8 are as defined in the specification. The compounds of formula I...
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