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7625949 |
Methods for treating retroviral infections
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c ...
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7619097 |
Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential...
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7618995 |
Derivatives of 4,5-diarylpyrrole, preparation method thereof and use of same in therapeutics
The invention relates to compounds having formula (I):
Wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the preparation method thereof and the use...
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7608633 |
Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2
The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A 2 , pharmaceutical preparations containing these compounds and a method of...
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7550491 |
Ionic liquids having [N(CF3)2]− anions
The present invention relates to salts comprising bis(trifluoromethyl)imide anions and saturated, partially or fully unsaturated, heterocyclic cations, to a process for the preparation thereof, and...
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7488832 |
Azolylacylguanidines as β-secretase inhibitors
The present invention provides an azolylacylquanidine compound of formula I
The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid...
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7473703 |
Heterocyclic arylsulfonamidobenzylic compounds
Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7411093 |
Aminocycloalkanes as DPP-IV inhibitors
The present invention relates to compounds of formula (I)
wherein R 1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for...
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7326696 |
Amino-methyl substituted tetracycline compounds
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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7323491 |
Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically...
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7323490 |
Pyrrole compounds and uses thereof
The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The...
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7300934 |
Benzamide nitriles
Compounds of the formula (I)
wherein m, n, A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein, together with methods for making the compounds and using the compounds for treatment...
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7297713 |
Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof
Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof,
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein. These compounds are...
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7291643 |
Cyanopyrrole-sulfonamide progesterone receptor modulators and uses thereof
Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof,
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein, are useful for...
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7250444 |
Pyrrole-based HMG-CoA reductase inhibitors
HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and...
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7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
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7241803 |
Compounds for inhibition of HIV infection by blocking HIV entry
A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC...
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7217707 |
Amide of R-2-(aminoaryl)-propionic acid for use in the prevention of leucocyte activation
N-(2-aminoaryl-propionyl)-amides of formula (1) are described.
The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7186749 |
Pyrrolo-naphthyl acids and methods for using them
The present invention relates to pyrrolo-naphthyl compounds of the formula
and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
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7186748 |
N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands
The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system:
wherein X is (CH...
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7179825 |
Retinoic acid mimetic anilides
The present invention is concerned with compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7160916 |
Method of increasing bone density or treating osteoporosis
This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula:
A...
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7153881 |
Compounds acting as melanocortin receptor ligands
The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system:...
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RE39420 |
1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses
Compounds of formula (I) and (II):
[wherein R is hydrogen, halogen or alkyl; R 1 is alkyl, amino or substituted amino; R 2 is optionally substituted phenyl; R 3 is hydrogen, halogen or...
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7122572 |
Calixpyrroles
The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates,...
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7122569 |
Ethylene glycol esters as photoactive agents
New compounds useful in photodynamic therapy are of the formula
and their 1,4-diene isomers
and the metallated and/or labeled and/or conjugated forms thereof
wherein each R 1 is...
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7112606 |
Heterocyclic arylsulfonamidobenzylic compounds
Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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7056938 |
Method for scavenging radicals with urocanic acid, derivatives and analogues
Upon exposure to UVB, the epidermal component trans-urocanic acid is not only photoisomerized into cis-urocanic acid, but will also, at least in part, be photooxidized into urocanic acid oxidation...
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7049334 |
Enhancement of learning and memory and treatment of amnesia
A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I):
A is H, R, or
...
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7034018 |
Substituted pyrrole mannich bases to combat pain and allergic reactions
The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R 1 =H, a C 1-10 -alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br—, Cl or OH radical bound...
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7001918 |
7-pyrrolyl tetracycline compounds and methods of use thereof
A compound of Formula (I): wherein variables R, R 1 , R 2 , R 3 and A are as defined in the
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6972287 |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound...
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6949536 |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula:
or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially...
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6943187 |
Pyrrolidine derivative hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.
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6916846 |
Coumermycin analogs as chemical dimerizers of chimeric proteins
Coumermycin analogs of general formula I:
wherein X, a linking group, is selected from the group consisting of alkyl, aryl, diaryl, substituted alkyl, substituted aryl, alkyl with...
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6911468 |
Tyrosine phosphatase inhibitors
A compound of the formula (I):
wherein X 1 and X 2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of R 1 and R 2 is a cycle...
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6887893 |
Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia
Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia.
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6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
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6821989 |
Method of treating certain cancers using an estrogen agonist/antagonist
The present invention provides methods of treating cancer of the liver, ovarian cancer, a desmoid tumor, glioma, pancreatic cancer, or renal cell carcinoma using an estrogen agonist/antagonist. The...
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6797694 |
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca ), and the use of such compounds for the...
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6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
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6759427 |
Synthesis and methods of use of tetrahydroindolone analogues and derivatives
A tetrahydroindolone derivative or analogue comprises a 9-atom bicyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety...
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6737423 |
Substituted heterocyclo-norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and medicaments comprising them
Substituted heterocyclo-norbornylaminoderivatives having: a) an exo-configuration nitrogen and an endo-fused five-membered ring or six-membered ring of the formula (I) or b) an exo-configuration...
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