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7544709 |
Derivatives of andrimide and moiramide B having antibacterial properties
The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or...
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7517880 |
Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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7504430 |
Maleiimide anti-tumor phosphatase inhibitors
The present invention features maleiimide compounds, pharmaceutical compositions of maleiimide compounds and methods of treating a patient suffering from cancer, the method comprising administering...
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7446118 |
3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof
The present invention provides compounds of the formula:
or pharmaceutically acceptable salts, solvates or prodrugs thereof,
wherein p, Ar, R 1 , R 2 , R 3 , R a , R b , R c , R d and R e ...
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RE40525 |
Hepatitis C inhibitor tri-peptides
A racemate diastereoisomer and optical isomer of a compound of formula (I):
wherein B is H, a C 6 or C 10 aryl, C 7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally...
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7348357 |
Arylamides
The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people...
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7329634 |
3-Phenyl substituted 3-substituted-4ketolactams and ketolactones
The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I)
in which Q, W, X, Y, A, B and G are as defined in the disclosure, to...
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7297712 |
Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment
The present invention provides novel cationic amphiphiles capable of facilitating transport of biologically active molecules into cells wherein the said amphiphiles contain cyclic head group having...
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7294649 |
Methamphetamine derivatives and conjugates for immunoassay
Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the...
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7288565 |
Azasugar compound
The present invention provides a compound represented by the formula (I) or a salt thereof:
wherein R 1 represents a hydrogen atom, a C 1-10 alkyl group optionally having a substituent, or a...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7189756 |
Pyrrolidine derivatives
The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with...
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7186739 |
Stabilized activated derivatives of carbamic acid, their process of preparation and their use for the preparation of ureas
A carbamate compound is disclosed.
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7173059 |
Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same
Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7109232 |
Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
The present invention relates to novel mixture and maleic and succinic acid derivatives from mycelium of Antrodia Camphorata and the medical use thereof. The present invention relates to the...
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7084138 |
Active ingredient combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the groups...
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7060692 |
Active ingredient combinations comprising insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the groups...
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7056889 |
Compounds that bind P2Y2 or P2Y1 receptors
The invention provides peptides and compounds that can bind to P2Y 2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7026350 |
Water-soluble drugs and methods for their production
The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of...
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RE38934 |
Method and reagents for N-alkylating ureides
A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I
with an alkylating agent of structure III
in the presence of a basic catalyst...
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6982097 |
Biocidal compositions and methods of using same
This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using...
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6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
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6962943 |
Gabusectin derivatives, processes for preparing them and their use
The present invention relates to compounds of the formula (I)
which are formed by the microorganism ST 003236 (DSM 14476) during fermentation, to a process for preparing and derivatizing them,...
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6960610 |
Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
The present invention provides methods which may effectively be used in the treatment and prevention of early cardiac and early cardiovascular diseases, for example of ischemic origin, such as left...
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6960474 |
Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator
Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the...
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6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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6903131 |
3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
Disclosed are compounds of the formula (I)
or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and...
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6774140 |
Iminocyclitol inhibitors of hexoaminidase and glycosidase
Designed iminocylitols that have potent inhibition activity with respect to hexominidases and glycosides are disclosed.
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6765003 |
3-Arylsulfonyl-2 (substituted methyl) propanoic acid derivatives as matrix metalloproteinase inhibitors
Compounds which are 3-arylsulfonyl-2-methyl propanoic acid derivatives of formula (I): wherein X is HO—NH— or HO—, R1 is selected from phenyl, 4-chlorophenyl, 4-florophenyl, 4-cyanophenyl,...
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6759430 |
Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress
The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O 2 − ) scavenger, their preparation and their use in the treatment of conditions...
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6719520 |
Method and compounds
A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the...
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6716872 |
Substituted pyrrolidine-2,3,4-trione 3-oxime derivatives which are active as NMDA receptor antagonists
Novel substituted pyrrolidine-2,3,4-trione compounds of formula I and methods for preparing the compounds. Also disclosed are pharmarceutical compositions comprising the compounds and methods of...
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6656964 |
Method of inhibiting phosphodiesterases with substituted alkanohydroxamic acids
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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6649616 |
Substituted phenylcyclohexanecarboxamides and their use
The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention...
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6642267 |
Substituted 1,5-dihydropyrrol-2-one derivatives active as NMDA receptor antagonists for treatment of states of pain
A substituted 1,5-dihydropyrrol-2-one compound of formula I: and methods for preparing the compounds. Also disclosed are pharmarceutical compositions comprising the compounds and methods of...
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6599921 |
Non-steroidal estrogen receptor ligands
Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor...
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6579900 |
Anandamide amidase inhibitors as analgesic agents
Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method and novel compounds can be used to reduce pain in...
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6576632 |
Biaryl compounds useful as anticancer agents
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
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6566384 |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.
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6486169 |
Botanical drug for treatment and prevention of alzhimer's disease
The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide...
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6476062 |
Chemokine receptor antagonists
Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium...
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6476053 |
Mycobacterial inhibitors
The invention provides the use of certain succinimide compounds in the treatment of mycobacterial diseases.
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6472419 |
1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents
The present invention relates to new 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) in which A, B, G, X, Y and Z have the meanings given in the description, to processes for...
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6455573 |
Glycosidase inhibitors and methods of synthesizing same
A method for synthesizing Salacinol, its stereoisomers, and non-naturally occurring selenium and nitrogen analogues thereof having the general formula (I): The compounds are potentially useful...
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6451844 |
Use of menthyl-2 pyrrolidone-5-carboxylate as an insect repellent
The use of menthyl 2-pyrrolidone-5-carboxylate as an insect repellent, usually by application to a substrate or into an air space. The menthyl 2-pyrrolidone-5-arboxylate can be used as a...
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6451843 |
Arylphenyl-substituted cyclic keto enols
The present invention relates to novel arylphenyl-substituted cyclic ketoenols, their preparation and the use of such ketoenols as pesticides and/or herbicides. The novel arylphenyl-substituted...
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6451836 |
Method of inhibiting liver glycogen phosphorylase with 2-alkylpyrrolidines
The present invention relates to (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine and other substituted 2-methylpyrrolidines and their use for inhibiting liver glycogen phosphorylase.
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