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7625949 |
Methods for treating retroviral infections
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c ...
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7625941 |
Ionic liquids
The present invention relates to compositions of matter that are useful as ionic liquids. The compositions of the invention are based on an N-substituted pyrrolidinone, said pyrrolidinone having a...
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7608637 |
Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP 4 agonist as an active ingredient. An EP...
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7608636 |
Medicines for treatment and prevention of neurogenic pain
A medicament for therapeutic and/or prophylactic treatment of neuropathic pain, which comprises a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an...
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7601753 |
Pyrrolidine melanocortin-specific compounds
Melanocortin receptor-specific pyrrolidine compounds having the structure:
and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
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7598288 |
Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
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7592364 |
Substituted gamma lactams as therapeutic agents
Therapeutic compounds, compositions, medicaments, and methods are disclosed herein.
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7585887 |
Active agent combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the groups...
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7585882 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I:
wherein R 1 , R 2 ,...
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7576102 |
Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation
The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general...
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7569598 |
Process for the preparation of the R,R (or S,S) configured glycopyrronium stereoisomer
The present invention relates to a process for the enrichment of the R,R- or S,S-configured glycopyrronium isomers and their thienyl derivatives having the R,S or S,R configuration.
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7557137 |
Gamma-lactams as beta-secretase inhibitors
There is provided a series of novel substituted gamma-lactams of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, their pharmaceutical compositions and methods of use....
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7550453 |
2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof
The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7547685 |
Therapeutic substituted pyrrolidone compounds
Compounds comprising
or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are...
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7544676 |
Sulfamoyl benzamides and methods of their use
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
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7491745 |
Pyrrole-Type compounds, compositions and methods for treating cancer or viral disease
The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder...
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7485664 |
Inhibitors of TACE
The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
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7485662 |
Therapeutic agent for diabetes mellitus
An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds...
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7485641 |
Substituted 3-amino-pyrrolidino-4-lactams
The invention provides compounds of formula (1),
and the pharmaceutically acceptable salt thereof, wherein R 1 , n and R 2 are as described herein; compositions thereof; and uses thereof.
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7482475 |
Therapeutic lactams
Disclosed herein is a compound having a structure
Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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7476747 |
Substituted gamma lactams as therapeutic agents
A compound comprising
or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein.
Methods, compositions, and medicaments...
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7465751 |
1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor...
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7462594 |
Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (II). Each variable is defined in the...
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7456210 |
Benzyloxy derivatives
The present invention relates to compounds of formula I
wherein R 1 and R 2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases,...
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7425575 |
Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones
The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I)
in which
A, B, Q, G, W, X, Y, Z and R 3 are as defined above, to processes and...
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7419999 |
Gamma lactams as prostaglandin agonists and use thereof
1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are...
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7414071 |
Methods of treatment with selective EP4 receptor agonists
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the...
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7402606 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
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7402605 |
8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
An 8-azaprostaglandin represented by formula (I)
(wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin...
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7396846 |
Growth hormone secretagogues
This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the...
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7345087 |
Aminocyclohexyl ether compounds and uses thereof
Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and...
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7345086 |
Uses of ion channel modulating compounds
Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods,...
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7345082 |
Phosphinic acids
The present invention relates to phosphinic acid derivatives of formula I
wherein R 1 , R 2 , R 3 and R 4 are described hereinabove. These compounds can be used in the treatment or prevention...
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7338975 |
Lactams as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7329685 |
1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases
The invention relates to compounds of formula (I):
wherein substituents are as defined.
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7326696 |
Amino-methyl substituted tetracycline compounds
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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7321063 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7312218 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
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7304088 |
Protease inhibitors
This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (I). Each variable is defined in the...
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7300929 |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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7297712 |
Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment
The present invention provides novel cationic amphiphiles capable of facilitating transport of biologically active molecules into cells wherein the said amphiphiles contain cyclic head group having...
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7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
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7288565 |
Azasugar compound
The present invention provides a compound represented by the formula (I) or a salt thereof:
wherein R 1 represents a hydrogen atom, a C 1-10 alkyl group optionally having a substituent, or a...
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7276531 |
G-lactam derivatives as prostaglandin agonists
A gamma-lactam diene of Formula I:
which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and...
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7256211 |
8-azaprostaglandin derivatives and medical use thereof
The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I)
(wherein, all the symbols have the same meanings as that of...
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7253205 |
Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 represent a variety of substituents, ring A is a phenyl or pyridyl...
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7253198 |
Hydroxyethylamine derivatives for the treatment of Alzheimer's disease
The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing...
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7244753 |
Cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least...
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7235581 |
4-pyrrolidino-phenyl-benzyl ether derivatives
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the...
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