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7625949 Methods for treating retroviral infections  
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c ...
7625941 Ionic liquids  
The present invention relates to compositions of matter that are useful as ionic liquids. The compositions of the invention are based on an N-substituted pyrrolidinone, said pyrrolidinone having a...
7608637 Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient  
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP 4 agonist as an active ingredient. An EP...
7608636 Medicines for treatment and prevention of neurogenic pain  
A medicament for therapeutic and/or prophylactic treatment of neuropathic pain, which comprises a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an...
7601753 Pyrrolidine melanocortin-specific compounds  
Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
7598288 Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma  
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
7592364 Substituted gamma lactams as therapeutic agents  
Therapeutic compounds, compositions, medicaments, and methods are disclosed herein.
7585887 Active agent combinations with insecticidal and acaricidal properties  
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the groups...
7585882 Phosphodiesterase 4 inhibitors  
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R 1 , R 2 ,...
7576102 Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation  
The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general...
7569598 Process for the preparation of the R,R (or S,S) configured glycopyrronium stereoisomer  
The present invention relates to a process for the enrichment of the R,R- or S,S-configured glycopyrronium isomers and their thienyl derivatives having the R,S or S,R configuration.
7557137 Gamma-lactams as beta-secretase inhibitors  
There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, their pharmaceutical compositions and methods of use....
7550453 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof  
The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
7550448 Therapeutic compounds  
Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
7547685 Therapeutic substituted pyrrolidone compounds  
Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are...
7544676 Sulfamoyl benzamides and methods of their use  
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
7491745 Pyrrole-Type compounds, compositions and methods for treating cancer or viral disease  
The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder...
7485664 Inhibitors of TACE  
The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
7485662 Therapeutic agent for diabetes mellitus  
An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds...
7485641 Substituted 3-amino-pyrrolidino-4-lactams  
The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R 1 , n and R 2 are as described herein; compositions thereof; and uses thereof.
7482475 Therapeutic lactams  
Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
7476747 Substituted gamma lactams as therapeutic agents  
A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments...
7465751 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists  
This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as muscarinic receptor...
7462594 Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases  
This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (II). Each variable is defined in the...
7456210 Benzyloxy derivatives  
The present invention relates to compounds of formula I wherein R 1 and R 2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases,...
7425575 Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones  
The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R 3 are as defined above, to processes and...
7419999 Gamma lactams as prostaglandin agonists and use thereof  
1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are...
7414071 Methods of treatment with selective EP4 receptor agonists  
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the...
7402606 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss  
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
7402605 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient  
An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin...
7396846 Growth hormone secretagogues  
This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the...
7345087 Aminocyclohexyl ether compounds and uses thereof  
Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and...
7345086 Uses of ion channel modulating compounds  
Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods,...
7345082 Phosphinic acids  
The present invention relates to phosphinic acid derivatives of formula I wherein R 1 , R 2 , R 3 and R 4 are described hereinabove. These compounds can be used in the treatment or prevention...
7338975 Lactams as modulators of chemokine receptor activity  
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
7329685 1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases  
The invention relates to compounds of formula (I): wherein substituents are as defined.
7326696 Amino-methyl substituted tetracycline compounds  
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
7321063 Sulfonamide inhibitors of aspartyl protease  
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
7312218 Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors  
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
7304088 Protease inhibitors  
This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (I). Each variable is defined in the...
7300929 Mediators of hedgehog signaling pathways, compositions and uses related thereto  
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
7297712 Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment  
The present invention provides novel cationic amphiphiles capable of facilitating transport of biologically active molecules into cells wherein the said amphiphiles contain cyclic head group having...
7291620 N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease  
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
7288565 Azasugar compound  
The present invention provides a compound represented by the formula (I) or a salt thereof: wherein R 1 represents a hydrogen atom, a C 1-10 alkyl group optionally having a substituent, or a...
7276531 G-lactam derivatives as prostaglandin agonists  
A gamma-lactam diene of Formula I: which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and...
7256211 8-azaprostaglandin derivatives and medical use thereof  
The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of...
7253205 Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents  
The present invention relates compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 represent a variety of substituents, ring A is a phenyl or pyridyl...
7253198 Hydroxyethylamine derivatives for the treatment of Alzheimer's disease  
The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing...
7244753 Cyclooxygenase-2 selective inhibitors, compositions and methods of use  
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least...
7235581 4-pyrrolidino-phenyl-benzyl ether derivatives  
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the...