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9040575 Combination for the treatment of osteoarthritis  
The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a...
9034913 Process for annealing amorphous atorvastatin  
Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
9029406 N-carboxyalkylauristatins and use thereof  
The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these...
9018206 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
9018237 Methods for improved wound closure employing olivamine and endothelial cells  
The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition...
9012454 Sexual dysfunction  
This document provides methods and materials related to treating mammals (e.g., humans) having a sexual dysfunction that is refractory to treatment with a PDE V inhibitor. For example, methods and...
9006249 Substituted aminobutyric derivatives as neprilysin inhibitors  
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for...
9006283 Methods of modifying amyloid β oligomers using non-peptidic compounds  
Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers. Also disclosed...
8987322 Pharmaceutical formulations for carrier-mediated transport statins and uses thereof  
The present invention relates to formulations comprising therapeutically effective amounts of at least one acid-stable, carrier-mediated transport statin, at least one poorly water-soluble,...
8987306 Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold  
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use....
8980936 Phenoxy-pyrrolidine derivative and its use and compositions  
The present invention is directed to the compound 2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenox y)pyrrolidin-1-yl)ethanone, its use as an inhibitor of stearoyl CoA desaturase and to...
8980868 Oral forms of a phosphonic acid derivative  
Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic...
8969397 Systems and methods to treat pain locally  
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting...
8957000 Use of sarmentine and its analogs for controlling plant pests  
Methods and compositions for controlling plant pests, particularly weeds and/or plant phytopathogens using sarmentine and/or analogs thereof are disclosed.
8951999 Compounds  
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as...
8945623 Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use  
The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive...
8933115 Stabilized statin formulations  
The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.
8927533 Thio derivatives bearing lactams as potent HDAC inhibitors and their uses as medicaments  
The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in...
8927460 Biocide compositions comprising derivatives of pyroglutamic acid  
Described are agrochemical compositions, comprising (a) esters and/or amides of pyroglutamic acid, and (b) biocides. The compositions are clear and exhibit an improved stability even when stored...
8927590 Synthesis of pyrrolidine compounds  
Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxyli c acid hydrochloride, and methods for...
8916550 Compounds for modulating TRPV3 function  
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
8916605 Compounds and methods for treating cancer and viral infections  
The present application relates to the use of one or more compounds of Formula (I) or pharmaceutically acceptable solvates or prodrugs thereof, for treating cancer or for treating or preventing a...
8895607 Inhibitors of the amino acid transporters ASCT1 and ASCT2  
The present invention relates to a compound of Formula (I) or (II) or a salt thereof, wherein R is described herein. The compounds are novel hydroxy-proline analog inhibitors of the ASCT1 and...
8883852 Radioprotective agents  
Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an...
8877799 Inorganic salt complexes of vildagliptin  
The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further...
8871784 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them  
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced...
8871798 Tricyclic pyridyl-vinyl pyrroles as PAR1 inhibitors  
This disclosure relates to compounds of formula I: wherein R1, R2, R3, R4, X and Y have the meanings denoted in the disclosure. The compounds of formula I have antithrombotic activity and in...
8871208 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof  
A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of...
8859590 Inhibitors of BACE1 and methods for treating Alzheimer's disease  
Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described.
8859537 Pharmaceutical composition for treating and/or preventing a pathology associated with an obsessional behavior or with obesity  
This invention relates to the use of a ligand of the 5-HT4 receptor or of a pharmaceutically acceptable salt of this ligand and to a nucleic acid coding for a 5-HT4 receptor or of a functionally...
8853256 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8846616 Alpha-melanocyte stimulating hormone as topical anti-inflammatory agent for the treatment of allergic contact dermatitis and eczema  
A method is presented for treating an inflammatory skin disorder in a human comprising: topically applying to the skin a composition comprising alpha-melanocyte stimulating hormone (αMSH) or an...
8840923 Slow-release pharmaceutical formulation and process for its preparation  
Slow-release excipients which comprise an association of at least one glycogen and at least one alginate with an alkaline-earth metal salt are useful for the preparation of slow-release...
8835480 Inhibitors for steroid response elements and related methods  
The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The invention also relates to methods to treat diseases related to ARE-,...
8822527 Substituted biaryl alkyl amides  
Disclosed herein are substituted biaryl alkyl amide compounds, methods of synthesizing substituted biaryl alkyl amide compounds and methods of treating diseases and/or conditions with substituted...
8822496 Dosage regimens for HCV combination therapy  
The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin...
8822463 Methylcyclohexane derivatives and uses thereof  
A novel methylcyclohexane derivative, and a pharmaceutical composition including the same that is effective for the prevention or treatment of pain.
8809311 Nutritional supplements  
A process for improving the health of a subject, the process comprising orally administering a composition comprising hydroxytyrosol to the subject to provide the subject with a daily dose of...
8802659 Bicyclic aryl sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
8802142 Pharmaceutical compositions comprising levetiracetam and process for their preparation  
The present invention relates to a pharmaceutical composition comprising levetiracetam as active ingredient and 2.0 to 9.0% per weight of disintegrant, 0.0 to 3.0% per weight of gliding agent, 0.5...
8802718 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8796315 Methods for improved wound closure employing olivamine and human umbilical vein endothelial cells  
The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition...
8791100 Aryl benzylamine compounds  
The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
8785443 Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof  
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical...
8785419 Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same  
Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit...
8785475 Lipoic acid derivatives  
Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive...
8772329 Compounds from mycelium of Antrodia cinnamomea and use thereof  
The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus...
8765681 IAP BIR domain binding compounds  
Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are...
8765794 Compositions and methods for wound care  
The present disclosure relates to compositions for and methods of repairing the stratum corneum, compositions and methods for inhibiting excessive transepidermal water loss, compositions for and...
8759365 Organic compounds  
The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be...