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6509379 |
Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides
Phenylacetic acid derivatives of the formula I where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful...
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6506788 |
N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving...
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6500856 |
Cyclic AMP-specific phosphodiesterase inhibitors
Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other...
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6495590 |
Use of amtolmetin guacyl for the production of anti-inflammatory drugs for intestinal inflammations
The present invention relates to the use of amtolmetin guacyl for the production of an anti-inflammatory drug for intestinal inflammations. Furthermore, the uses of amtolmetin guacyl for the...
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6486169 |
Botanical drug for treatment and prevention of alzhimer's disease
The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide...
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6486151 |
N-oxides of heterocyclic esters, amides, thioesters, and ketones
This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their...
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6486193 |
3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
The present invention provides novel 3-substituted pyrrolidines of the formula useful in as inhibitors of matrix metallo-proteinases (MMPs). Pharmaceutical compositions containing said compounds...
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6479524 |
Substituted aryl and heteroaryl derivatives, their production and their use as medicines
Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrol
idinocarbonyl)-phenyl]-propargylamino}benzamidine, (b)...
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6479518 |
Zwitterionic tachykinin receptor antagonists
The present invention is directed to certain novel compounds represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein R 3 , R 5 , R 6 , R 7 , R 8 , R 11 , R 12...
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6476061 |
Fungicides containing pyrrolidones as their active agents
The invention relates to fungicides containing compounds of formula (I) as their active agents, the radicals in said formula (I) having the following meanings: R 1 is hydrogen, C 1 -C 6 -alkyl, C...
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6469047 |
Tyrosine derivatives
The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
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6465471 |
Cinnamic acid derivatives
Compounds of formula (1) are described: in which Het is a heteroaromatic group, Alk 1 is an optionally substituted aliphatic or heteroaliphatic chain and R is a carboxylic acid or a derivative...
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6462072 |
Cyclic ester or amide derivatives
This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods...
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6462073 |
N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases...
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6455574 |
Therapeutic combination
This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a pharmaceutically acceptable salt thereof, kits...
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6455531 |
Hydroxamic acid derivatives
Compounds having therapeutic utility are of the formula wherein NB 2 is heterocycloalkyl and R 1 and R 2 are each various substituents or a cyclic group.
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6451844 |
Use of menthyl-2 pyrrolidone-5-carboxylate as an insect repellent
The use of menthyl 2-pyrrolidone-5-carboxylate as an insect repellent, usually by application to a substrate or into an air space. The menthyl 2-pyrrolidone-5-arboxylate can be used as a...
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6448286 |
Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
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6444700 |
Product and method to reduce stress induced immune suppression
In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress....
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6433002 |
Pesticidal 1-polyarylpyrroles
A compound of formula (I): compositions containing them and methods of use to control pests.
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6432969 |
N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
The present invention relates to certain N-(substituted glycyl)-2-cyanopyrrolidines of formula I wherein Y is as defined herein, in free form or in acid addition salt form. Compounds of formula...
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6429215 |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
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6429213 |
Cyclic hydroxamic acids as metalloproteinase inhibitors
The present application de gibes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2...
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6426355 |
Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
Compounds having the formula: wherein R 1 -R 5 , X and G are described herein and which are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus,...
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6417219 |
Hetero-substituted cyclic amine metalloprotease inhibitors
The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular,...
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6407135 |
Conjugates of dithiocarbamates with pharmacologically active agents and uses therefor
In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or “DC”) and pharmacologically active agents (e.g., NSAIDs)....
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6403584 |
Substituted nipecotyl derivatives as inhibitors of cell adhesion
Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
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6399628 |
N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
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6399649 |
Compositions and methods for the treatment of chronic lymphocytic leukemia
Methods for treating patients with CLL with pharmaceutical agents are disclosed. The methods of the present invention can be used in patients that have not responded to standard treatment. In...
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6399629 |
Efflux pump inhibitors
Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such...
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6399648 |
N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-Oxides of...
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6395758 |
Small molecule carbamates or ureas for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule...
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6395737 |
Malonic acid derivatives, processes for their preparation, for their use and pharmaceutical compositions containing them
New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I, wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings...
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6387894 |
Use of CRF antagonists and renin-angiotensin system inhibitors
The present invention relates to compositions and methods of achieving a therapeutic effect including, but not limited to, the treatment of congestive heart failure or hypertension in an animal,...
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6387943 |
Vancoresmycin, a process for its production and its use as a pharmaceutical
The present invention relates to a compound named Vancoresmycin which is obtainable by cultivation of the microorganism HIL-006734 (DSM 12216), and to its pharmaceutically acceptable salts. The...
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6384056 |
Heterocyclic thioesters or ketones for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic...
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6380241 |
Treatment of diseases using endothelin antagonists
A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing...
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6369077 |
Protease inhibitors
This invention relates to compounds of formula (I): wherein: Y is Ar or NR 1 R 2 ; R 1 is R″, R″C(O), R″C(S), R″SO 2 , R″OC(O), R″R′NC(O), or R″R′NC(S); R 2 is H, C 1-6...
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6369069 |
Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament
The invention relates to compounds of the formula (I), in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4,...
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6365621 |
Remedies or preventives for intractable epilepsy
A therapeutic or preventive agent for intractable epilepsy comprising as an active ingredient a compound represented by R 2 —CH 2 CONH—R 1 (I), wherein R 1 is a phenyl group or a pyridyl...
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6365620 |
Trifluoromethylpyrrolcarboxamides
The invention relates to pesticidal trifluoromethylpyrrolcarboxamides of formula I wherein R 1 is hydrogen, halogen, C 1-4 haloalkyl or C 1-4 alkyl, R 2 is C 1-4 alkyl, C 1-4 haloalkyl, C 1-4...
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6365592 |
Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B)
The invention encompasses compounds represented by formula I: as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.
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6362165 |
Hydroxyphenyl derivatives with HIV integrase inhibitory properties
An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts...
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6362236 |
Inhibition of lipoprotein oxidation
Hydroxylated derivatives of cholesterol lowering agents inhibit the oxidation of lipoproteins, and are thus useful for preventing the progression of atherogenesis and resultant vascular diseases,...
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6362174 |
Reduced dipeptide analogues as calcium channel antagonitsts
The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke,...
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6362215 |
Composition for laying hens containing calcium L-pidolate
The invention concerns the use of calcium L-pidolate for obtaining an agent improving the quality of eggshells and a composition capable of being administered to laying hens. Said composition is...
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6348464 |
Pyrrolecarbonylimino derivatives as naaladase inhibitors
The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity,...
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6346547 |
N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general...
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6339101 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
This invention relates to novel compositions and uses of a N-linked sulfonamide of an N-heterocylic carboxylic acid or isostere thereof for treating a vision disorder or improving vision or...
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6337394 |
Compounds
There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R x , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases,...
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