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6689807 |
HMG CoA reductase inhibitors for promoting angiogenesis
This invention relates to methods and compositions for the treatment of conditions associated with vascular insufficiency, and to methods and compositions for screening assays to select agents that...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6686386 |
Use of a RAR-&ggr -specific agonist ligand for increasing the rate of apoptosis
The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-γ type, which are characterized as...
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6683112 |
Gabapentin prodrugs and formulations
The present invention relates to novel prodrugs of gabapentin and to pharmaceutical formulations and sustained release formulations containing the prodrugs.
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6680341 |
Stable pharmaceutical formulation comprising a HMG-CoA reductase inhibitor
Atorvastatin and pravastatin may be destabilized by the environmental factors, their degradation may also be accelerated by interactions with other pharmaceutical ingredients, such as fillers,...
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6673801 |
Dihydroxyhexanoic acid derivatives
Dihydroxyhexanoic acid derivatives of the general formula are useful to treat inflammation and other immune disorders.
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6653336 |
Combination of hypertensin converting enzyme inhibitor with a diuretic for treating microcirculation disorders
The present invention relates to the use of a combination of an antiotensin-converting enzyme inhibitor (CEI) and of a diuretic for the treatment of arteriolo-capillary microcirculatory disorders...
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6649603 |
Cyclylamine sulfonamides as β3-adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are...
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6649639 |
Antipicornaviral compounds, compositions containing them, and methods for their use
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical...
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6645995 |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
Described are compounds of formula I wherein at least one of the bonds in the five-membered ring is a double bond; B is any alpha or beta amino acid connected to the ring with an amide or...
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6641810 |
Methods of using geldanamycin and FK506 to treat peripheral nerve damage
FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid...
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6635650 |
Substituted dimeric compounds
The invention relates to compounds of formula (I): A-G 1 -Cy-G 2 -Cy-G 3 -B (I) wherein: A represents NR 1 C(Q)R 2 , C(Q)NR 2 R 3 or NR 1 C(Q)NR 2 R 3 , B represents NR 1 C(Q)R 2 , C(Q)NR 2 R 3...
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6630502 |
Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
A method is provided for slowing the progression of atherosclerosis in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients by administering a...
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6630504 |
Phenoxyphenylheterocyclyl derivatives as SSRIs
The invention provides compounds of general formula (I) wherein R 1 is H or C 1 -C 6 alkyl; R 2 and R 3 , together with the interconnecting atoms form a 4 to 8-membered saturated ring containing...
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6616933 |
Excitatory amino acid inhibitors for treating sensitive skins
Sensitive human skin/scalp/mucous membrane conditions, for example skin irritation and/or dry patches and/or erythemas and/or dysaethetic sensations and/or sensations of heating and/or pruritus,...
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6613793 |
Anticancer activity of imino acid conjugates or methylglyoxal
The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of...
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6613794 |
Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
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6610719 |
Use of prostaglandin (PGE2) receptor a (EP4) selective agonists for the treatment of acute and chronic renal failure
This invention is directed to methods and compositions of treating acute or chronic renal failure or dysfunction, or conditions caused thereby, comprising administering prostaglandin agonists,...
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6610682 |
Pharmaceutical compositions and methods for the treatment of arteriosclerosis
A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme...
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6605636 |
Atorvastatin hemi-calcium form VII
The present invention provides a novel form of atorvastatin hemi-calcium designated Form VII and novel processes for its preparation whereby another crystalline form of atorvastatin hemi-calcium is...
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6605641 |
20-HETE antagonists and agonists
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of...
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6599930 |
Coniosetin and derivatives thereof, process for the preparation and the use thereof
The present invention relates to novel active substances (coniosetin and coniosetin derivatives) of the formula I which are produced by the microorganism Coniochaeta ellipsoidea Udagawa (DSM...
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6599931 |
Test system for characterizing the compatibility of bioactive substances and polyvinylpyrrolidone
A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and...
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6596755 |
Oral formulation of methylglyoxal and its imino acid conjugates for human use
The invention relates to an oral formulation of methylglyoxal and/or its imino acid conjugates for human use and methods for preparing the compositions. Particularly, the invention relates to...
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6596754 |
Preventives/remedies for multiple organ failure
The present invention relates to a preventive and/or therapeutic drug for hypercytokinemia, liver diseases, and syndromes caused by the aggravation of sepsis, containing an anti-thrombin agent...
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6596752 |
Inhibitors of α4β1 mediated cell adhesion
The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of α 4 β 1 mediated adhesion to either VCAM or CS-1 and which can be used for...
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6593312 |
Cyclic α-amino-&ggr -hydroxyamide compounds
A compound of formula (I): wherein: represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R 1 and R 4 , which may be identical or different, each...
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6593347 |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
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6589962 |
Alpha-hydroxy-gamma-&lsqb &lsqb (carbocyclic-or heterocyclic-substituted)amino&rsqb carbonyl&rsqb alkanamide derivatives and uses thereof
Certain α-hydroxy-γ-[[(carbocyclic- or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives are described as inhibitors of HIV protease and inhibitors of HIV replication. These...
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6586438 |
Antidiabetic formulation and method
A low dose antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes in drug naive patients, which includes a combination of metformin (employed in a...
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6579889 |
Substituted isonipecotyl derivatives as inhibitors of cell adhesion
Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
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6576657 |
Amidino derivatives and their use as thrombin inhibitors
There is provided compounds of formula I, wherein R 1 , R x , Y, R y , n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
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6573267 |
Useful aroyl aminoacyl pyrrole compounds
This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of...
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6548533 |
Ureido substituted pyrrolidines
The invention is directed to physiologically active compounds of formula (I): wherein one of A 1 , A 2 and A 3 represents NR 2 and the others represent C(R 3 )(R 4 ); R 1 represents R 5 Z 1...
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6548451 |
Use of derivatives of 2-oxopyrrole as crop protection agents and novel 2-oxopyrroles
The invention relates to the use of 2-oxopyrroles of general formula (I) and their agriculturally usable salts as crop protection agents and to novel 2-oxopyrroles of formula (I). The substituents...
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6541491 |
4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors
Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R 1 is for example H and further values as defined in the specification; R 2 is for example H and...
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6534538 |
Method for slowing heart valve degeneration
The present invention involves a method for slowing heart valve degeneration in which an inhibitor of hydroxymethylglutaryl CoA reductase is administered.
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6534537 |
Use of HMG-COA reductase inhibitors to prevent and treat BPH
A method of preventing and treating benign prostatic hypertrophy or benign prostatic hyperplasia wherein the method involves administering to a human or an animal a sufficient amount of a HMG Co-A...
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6534536 |
Alkylsulfonamido heterocyclic thrombin inhibitors
Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl,...
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6525099 |
N-substituted sulfonamide derivatives
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
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6521644 |
Compositions for promoting growth
Inhibitors of dipeptidyl peptidase IV and pharmaceutical compositions comprising these inhibitors are useful in the treatment of short stature due to Growth-Hormone deficiency and for promoting...
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6521659 |
Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in...
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6521626 |
Thiocarboxamide derivatives
Compounds of formula (1): wherein R 1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or...
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6518299 |
Substituted pyrrolidine compounds useful as neuraminidase inhibitors
Certain substituted pyrrolidine compounds, pharmaceutically acceptable salts thereof, and their method of preparation are disclosed as well as use as influenza virus neuraminidase inhibitors.
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6515011 |
Thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. where R 3 ...
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6515023 |
Thrombin receptor antagonists
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which...
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6512004 |
Promoters of neural regeneration
The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent...
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6509359 |
Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors
A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.
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6509379 |
Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides
Phenylacetic acid derivatives of the formula I where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful...
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