|
Match
|
Document |
Document Title |
|
|
7446125 |
Derivatives of nitroproline compounds, processes of manufacture and uses in the treatment of integrin mediated disorders
This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also...
|
|
|
7439257 |
Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein m, n, X, Y, R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to the use of same in therapeutics.
|
|
|
7429613 |
Process for the preparation of atorvastatin and intermediates
A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phe
nylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptano
ic acid, R-substituted ester 9...
|
|
|
7427619 |
Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
|
|
|
7425641 |
Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to carboxylic acid amides of general formula
wherein
R 1 to R 5 , Ar, m and n are defined as in claim 1 , the tautomers, stereoisomers, mixtures thereof,...
|
|
|
7425576 |
Compounds as inhibitors of hepatitis C virus NS3 serine protease
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
|
|
|
7423058 |
Inhibitors of hepatitis C virus NS3 protease
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
|
|
|
7423170 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
|
|
|
7419974 |
Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
The present invention relates to the compounds of formula (I):
in which A is a group of formula (a) or (b)
in which R represents a hydrogen or halogen atom, an —S(O) z (C 1 -C 4 )alkyl...
|
|
|
7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
|
|
|
7411091 |
N-acyl-N′-benzyl-alkylendiamino derivatives
This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C 2 -C 8 alkyl chain; X is...
|
|
|
7410995 |
N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked...
|
|
|
7407974 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
|
|
|
7402606 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
|
|
|
7399869 |
Fibroblast activation protein inhibitor compounds and methods
Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP....
|
|
|
7396851 |
Heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of β-thalassaemia
The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a...
|
|
|
7388017 |
Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
|
|
|
7381727 |
Pyrrole derivatives, their preparation and their therapeutic use
The invention concerns compounds of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are as defined herein. The invention also concerns the method for preparing said...
|
|
|
7378440 |
Substituted benzoylureido-o-benzoylamides, process for their preparation and their use
The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of...
|
|
|
7378419 |
9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives
The invention relates to compounds of formula (I), wherein R 1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl,...
|
|
|
7378409 |
Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
|
|
|
7368469 |
Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic...
|
|
|
7365061 |
2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
|
|
|
7365092 |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
The present invention relates to compounds of formula I:
or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus...
|
|
|
7361663 |
N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa
This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing...
|
|
|
7351702 |
Caspase inhibitors and uses thereof
This invention provides compounds of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; next to R 3 represents a single or double bond;...
|
|
|
7348346 |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
The present invention relates to compounds of formula (I),
which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II...
|
|
|
7348356 |
Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
Disclosed are compounds of formula (I)
which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is...
|
|
|
7342041 |
3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
|
|
|
7338976 |
Heterocyclic esters or amides for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic...
|
|
|
7323489 |
Proline ester and preparation containing the same for percutaneous administration
A proline ester represented by the following formula (I):
wherein R 1 represents a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, or a lower alkoxy-lower alkoxy-lower alkyl group...
|
|
|
7323490 |
Pyrrole compounds and uses thereof
The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The...
|
|
|
7317008 |
Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The...
|
|
|
RE40000 |
Method of treatment for decreasing mortality resulting from congestive heart failure
A method of treatment using a compound of Formula I:
wherein:
R 1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R 2 is hydrogen,...
|
|
|
7314875 |
Tricyclic aromatic and bis-phenyl sulfinyl derivatives
The present invention provides compounds of the structure:
wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases...
|
|
|
7309714 |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
|
|
|
7307070 |
Microbicidal compositions
There are described the use of α-(4-chlorophenyl)-α-(1-cyclopropylethyl)-1H-1,2,4-triazol
e-1-ethanol as a microbicide for the protection of industrial materials, and compositions containing this...
|
|
|
7300929 |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
|
|
|
7294644 |
CB 1 receptor inverse agonists
The present invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and X are as defined in the description and claims, and pharmaceutically acceptable salts...
|
|
|
7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
|
|
|
7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
|
|
|
7285570 |
Compositions and methods for regulating mammalian keratinous tissue
Skin care compositions and methods for regulating the condition of mammalian keratinous tissue containg an effective amount of a dialkanoyl hydroxyproline compound and a second skin care compound...
|
|
|
7282517 |
Method of manufacturing glimepiride and the respective intermediate
A method of manufacturing glimepiride of formula I wherein trans-4-methylcyclohexylamine pivalate of formula VII is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or...
|
|
|
7282484 |
Anti-tumor agents
A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to...
|
|
|
7282514 |
Reactive probes for two-photon fluorescent imaging and sensing
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
|
|
|
7282510 |
Small molecule inhibitors of rotamase enzyme activity
This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated...
|
|
|
7276492 |
Use of ACE inhibitors for treatment of patients suffering from behavioral disorders
A method for the treatment of a patient suffering from an endogenous behavioral disorder in order to ameliorate at least some behavioral aspects of the disorder, the method comprising administering...
|
|
|
7268158 |
6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
|
|
|
7265150 |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
This invention relates to novel compositions and uses of N-heterocyclic carboxylic acids and carboxylic acid isosteres for treating a vision disorder, improving vision, treating memory impairment...
|
|
|
7265146 |
Integrin receptor inhibitors
Provided are compounds of formula (I)
wherein A, Q, W, X, Y, Z, R 1 to R 4 , m and n are as defined herein. Compounds of the invention bind to α 4 integrin receptors and thereby inhibit...
|