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6194440 |
Small molecule carbamate or urea hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using small molecule carbamates and ureas.
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6194450 |
Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'--...
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6187752 |
Method for treating schizophrenia employing an ace inhibitor
A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or...
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6180626 |
Vascular-permeability suppressants
A vascular permeability suppressant includes an oxaspirooctane derivative of the general formula (I): ##STR1## [wherein, R 1 represents, for example, lower alkylcarbamoyl group or protected...
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RE37035 |
Phenylacetic acid benzylamides
Phenylacetic acid benzylamides having the following general structure ##STR1## wherein the substituents are defined herein, are disclosed, which compounds are hypoglcemic agents.
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6177408 |
Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
A compound which is a distamycin derivative of formula (I), wherein n is 2, 3 or 4; R 0 is C 1 -C 4 alkyl or C 1 -C 3 haloalkyl; R 1 and R 2 , which may be the same or different, are each...
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6174898 |
Method of treating filariae
The present invention relates to a novel method for treating a mammal suffering from filariae.
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6174879 |
Aminocyclohexylesters and uses thereof
Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a...
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6172102 |
Pyrrole derivatives and medicinal composition
The invention relates to a pharmaceutical composition comprising a pyrrole derivative of the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate of either of them, as...
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6166015 |
Pyrrolidine derivatives-CCR-3 receptor antagonists
This invention relates to certain 3-aminomethylpyrrolidine derivatives of Formula (I): ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their...
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6166082 |
Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have...
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6166068 |
Immunomodulator, cell adhesion inhibitor, and agent for treating, and preventing autoimmune diseases
Autoimmune diseases, cell adhesion inhibition and immunomodulation are treated or effected by a method, comprising, treating a patient with a therapeutically effective amount of a...
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6160004 |
C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10...
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6156787 |
Substituted thienlycyclohexanone derivatives for enhancing cognition
The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof: ##STR1## where A is C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 alkynyl, C 3 -6 cycloalkyl, arylC 1 -6...
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6153624 |
Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders
The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formula ##STR1## wherein R 1 and R 2 are, independently from each other, hydrogen, lower alkoxy,...
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6147092 |
Lipophilic benzothiophenes
The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R 1 is N-pyrrolidinyl or N-piperidinyl; R 2 and R 3 are independently hydrogen,--CO--(C 10 -C 22 alkyl),...
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6140338 |
Chemokine receptor antagonists
The present invention relates to a compound of the general formula: ##STR1## wherein each of R 1 and R 2 which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower...
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6140321 |
Polymorphs of donepezil hydrochloride and process for production
Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the...
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6136844 |
5-aroylpyrrol-2-ylmethylarene derivatives
Compounds selected from the group of compounds represented by formula I: ##STR1## where: R 10 is represented by the formula (A), (B), or (C): ##STR2## R 20 is represented by the formula (U), (V),...
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6136847 |
Water-soluble trioxanes as potent and safe antimalarial agents
Biologically-active, water soluble, 3-substituted trioxanes of the formula ##STR1## wherein R represents a COOH-- substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl...
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6133288 |
Pentacyclic compounds, intermediates, processes, compositions, and methods
The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR 5 --; Y is --O--, --S--, --CH 2 --, --CH 2 CH 2 --, --CHCH--, or --NR 5 --; B...
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6133307 |
Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
The novel compounds of formula (I) of the instant invention are selective kappa opioid agonists useful in the treatment of arthritis, hypertension, pain, inflammation, migraine, inflammatory...
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6133279 |
Therapeutic agents for renal diseases and organ preservatives
Herein disclosed are therapeutic agents for renal diseases and organ preservatives containing a compound represented by the general formula (1): ##STR1## wherein X represents an oxygen atom or a...
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6124341 |
Endothelin antagonists
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of...
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6124319 |
3,3-disubstituted piperidines as modulators of chemokine receptor activity
The present invention is directed to 3,3-disubstituted piperidines of the formula I: ##STR1## (wherein X, Y, Z, Ar, R, m and n are defined herein) which are useful as modulators of chemokine...
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6124277 |
Antithrombotic agents
This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
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6124311 |
Methods for treating resistant tumors
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran,...
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6121309 |
Fused-ring carboxylic acid derivatives
The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a...
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6121293 |
Benzothiophene compounds, compositions, and methods
The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions...
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6121310 |
Aflatoxin contamination inhibitor and aflatoxin contamination-inhibiting method
An aflatoxin contamination inhibitor, which contains an actibiotic Blasticidin A of the following chemical formula (1) or its salt, ##STR1## and at least one selected from a solid carrier, a liquid...
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6110947 |
Pyrrolidinyl hydroxamic acid compounds and their production process
A compound of the formula: ##STR1## and it pharmaceutically acceptable salt, wherein A is hydrogen, hydroxy or OY, where Y is a hydroxy protecting group; Ar is phenyl optionally substituted with...
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6107311 |
Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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6106864 |
Pharmaceutical formulations containing darifenacin
There is provided a pharmaceutical dosage form adapted for administration to the gastrointestinal tract of a patient, comprising darifenacin, or a pharmaceutically acceptable salt thereof, and a...
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6103713 |
Therapeutic treatment for autoimmune diseases
Methods for inhibiting activation and/or proliferation of T cells and B cells and for treating autoimmune diseases and/or disease manifestations are disclosed, particularly using the isozyme...
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6103757 |
Methods for treating arrhythmia using acetate buffer solutions of amiodarone
Disclosed herein are methods for treating human patients suffering from arrhythmia comprising administration to the human a solutions containing a 3-diethylaminoethoxybenzoyl-benzofuran in acetate...
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6096764 |
Methods for inhibiting detrimental side-effects due to GnRH of GnRH agonist administration
A method of inhibiting detrimental side-effects of GnRH or GnRH agonist administration in a mammal which comprises the administration to a mannal in need thereof of an effective amount of a...
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6096766 |
3-benzylaminopiperidines as tachykinin receptor antagonists
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6075023 |
Method for combatting fish mycoses and one-celled ectoparasites
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6071947 |
Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
The present invention relates to substituted (1H-indol-2-yl)-5[(2H-pyrrol-2-ylidene) methyl]-1H-pyrrole compounds and their use as immunomodulating agents, to the preparation of the compounds and...
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6066662 |
Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
The invention provides hydroxylamine derivatives of formula (I) wherein A, R 1 , R 2 and R 3 have the significance given in the description, which are matrix metalloproteinase inhibitors and...
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6066652 |
Method for treating diseases of the inner ear using adamantane derivatives
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6060488 |
Benzothiophenes for treating estrogen deficiency
This invention is related to novel benzothiophene compounds of formula I: ##STR1## where R, R 1 , R 2 , X and m are as defined in the specification, which are useful for the inhibition of the...
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6057341 |
Bi-aromatic dibenzofuran derivatives and their use in human and veterinary medicine and in cosmetics
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6057357 |
Peripherally selective kappa opioid agonists
The compounds of the instant invention as those of Formula I ##STR1## or a pharmaceutically acceptable salt thereof are peripherally selective kappa opioid agonists that are useful in treating...
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6057342 |
Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof,...
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6051593 |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
The present invention relates to novel 3-(cycloalkanoheteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity...
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6043269 |
cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
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6040317 |
Sulfonamide fibrinogen receptor antagonists
A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases...
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6037340 |
Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds
Methods for preparing thiophene and pyrrole-based heterocyclic compounds are disclosed. Also disclosed are libraries of thiophene and pyrrole-based heterocyclic compounds, methods for preparing the...
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RE36617 |
(Substituted aralkyl) heterocyclic compounds
A (substituted-aralkyl)heterocyclic compound of the formula I ##STR1## wherein R 1 is an azido, carbamoyl, cyano, formyl, hydroxy or nitro radical, a 1-6C 1-hydroxyalkyl, alkoxy, alkylcarbamoyl,...
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