Matches 351 - 400 out of 1288 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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6348488 Remedies for motor dysfunction and GAPDH expression inhibitors  
Remedies for motor dysfunction and GAPDH expression inhibitors containing as the active ingredient N-[3-[N-(4-chlorophenylmethyl)carbamoyl]propanoyl]-L-prolina l. Since it has an effect of...
6348464 Pyrrolecarbonylimino derivatives as naaladase inhibitors  
The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity,...
6342517 Potassium channel activators and their use  
Novel thienopyran compounds are disclosed, useful as anti-hypertensive agents and for asthma treatment. One group of the compounds has a heterocyclic ring spiro-connected at the 7-position of the...
6340704 Cell differentiation inducing amide derivatives, their production and use  
The present invention provides a compound represented by the formula: wherein R 1 is an amino group which may be substituted; R 2 is a hydrogen atom or a lower alkyl group which may be...
6333042 Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained  
A substance P antagonist is used in a cosmetic composition to treat sensitive skin. More specifically, a cosmetic composition containing a substance P antagonist is used to prevent and/or combat...
6333340 Small molecule sulfonamides for vision and memory disorders  
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal using...
6329417 Hepatitis C inhibitor tri-pepitides  
Racemates, diastereolsomers and optical isomers of a compound of formula (I): ##STR1## wherein B is H, a C 6 or C 10 aryl, C 7 -16 aralkyl; Het or (lower alkyl)-Het, all of which optionally...
6329148 Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells  
A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the...
6316494 cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes  
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
6316467 Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides  
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
6316473 Two surfactant-containing medicinal composition  
Provided is a medicinal composition having a very satisfactory drug release profile and a very satisfactory drug absorption profile after oral administration characterized by its comprising an...
6313164 Dithiolin derivatives, their preparation and their therapeutic effect  
Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R 1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an...
6306890 Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors  
A compound of the formula ##STR1## where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.
6303569 Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents  
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: ##STR1## wherein: B is H, OH, OSiR 13 , a...
6294551 N-linked sulfonamides of heterocyclic thioesters  
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as...
6291484 Benzothiophenes  
This invention provides novel benzothiophene compounds of the formula I: ##STR1## which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as...
6291509 Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole compound  
A product containing: (a) an immunosuppressant agent (A) and (b) at least one immunosuppressant 2,2'-bi-1H-pyrrole compound (B) having formula (I) wherein R 1 is hydrogen, phenyl, C 1 -C 20 ...
6291511 Biarylalkanoic acids as cell adhesion inhibitors  
Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
6288105 Antithrombotic agents  
This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical...
6288058 Substituted tetracyclic tetrahydrofuran derivatives  
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
6284784 Substituted 2-pyrrolidinone activators of PKC  
Compounds of formula I: ##STR1## wherein R 1 and R 2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for...
6281229 Heat shock factor activity inhibitors  
A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor...
6281228 Heterocyclic inhibitors of microsomal triglyceride transfer protein and method  
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including...
6277833 Substituted triols  
Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
6277878 Substituted indole compounds as anti-inflammatory and analgesic agents  
This invention provides a compound of the following formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein R 1 is H or C 1 -4 alkyl; R 2 is C(L')R 3 or So 2 R 4 ; Y is a...
6274569 Pesticidal compositions  
An agrochemical composition, comprising at least two active ingredient components together with a suitable carrier, wherein component I is I) fludioxonil...
6274601 Methods of inhibiting ulcerative mucositis  
A method of inhibiting ulcerative mucositis comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are independently...
6271252 Cyclic amino acid derivatives as cell adhesion inhibitors  
Cyclic amino acid derivatives of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated...
6265428 Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin  
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
6262079 Prevention and treatment of cardiovascular pathologies  
A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): ##STR1## wherein Z is CO or a covalent bond; Y is H or O(C 1 -C 4 )alkyl, R 1 and...
6258826 Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome  
Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and...
6255306 4-indole derivatives as serotonin agonists and antagonists  
The present invention relates to compounds of the formula ##STR1##
6251919 Heterocyclic substituted aniline calcium channel blockers  
6251921 Antithrombotic diamines  
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of...
6251931 Inhibitors of gap junction communication  
Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a...
6245783 Method of using neurotrophic sulfonamide compounds  
This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme...
6235791 Use of amines to produce drugs for preventing tumor cell proliferation  
The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of...
6228867 Antagonists of gonadotropin releasing hormone  
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
6225324 Antidepressant heterocyclic compounds  
Compounds of formula I are useful antidepressant agents ##STR1## demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or...
6221838 Methods of treating neuropeptide Y-associated conditions  
This invention describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an analog of an obesity protein. This invention further describes...
6218423 Pyrrolidine derivatives for vision and memory disorders  
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using pyrrolidine...
6218411 Therapeutics for diabetic complications  
An agent for treating or ameliorating diabetic complications which contains at least one potassium channel activator as an active ingredient. The drug is expected to show a therapeutic or...
6214860 Synergistic antitumor composition containing a naphthalensulphonic acid derivative  
A pharmaceutical composition for use in antineoplastic therapy in mammals, including humans, comprising a biologically active ureido compound of formula (I) ##STR1## wherein each of m and n,...
6211225 Heterocyclic aminopyrrolidine derivatives as melatonergic agents  
There is provided a novel series of heterocyclic aminopyrrolidine compounds of Formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 , W, Z and the wavy bond {character pullout} are as defined herein...
6211201 Multivalent salts of pyridostigmine and related compounds  
A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some...
6200957 Antagonists of gonadotropin releasing hormone  
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
6197795 Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors  
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-α...
6197790 Benzothiophene compounds, intermediates, compositions, and methods  
A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I ##STR1## wherein R 1a is --H...
6197789 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues  
A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): ##STR1## wherein Z is CO or a covalent bond; Y is H or O(C 1 -C 4 )alkyl, R 1 and...
6194405 Method of using substituted tetracyclic tetrahydrofuran derivatives  
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
Matches 351 - 400 out of 1288 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >