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7138423 |
Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
The present disclosure relates to chemical compounds and their use in treatment of human diseases. A particular embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7138426 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7135484 |
Azabicyclic compounds are central nervous system active agents
Compounds of formula (I)
are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
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7135479 |
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
Compounds of the Formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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7132442 |
6H-thieno[2, 3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as gonadotrophin...
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7132434 |
Metalloproteinase inhibitors
Compounds of the formula (I), useful as metal-loproteinase inhibitors, especially as inhibitors of MMP12
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7129265 |
Synergistic effects of amlodipine and atorvastatin metabolite as a basis for combination therapy
The combination of amlodipine with atorvastatin metabolite shows a synergistic antioxidant effect on lipid peroxidation in human low-density lipoproteins and membrane vesicles enriched with...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7109186 |
HIV integrase inhibitors
The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7105565 |
Pyrrolcarboxamides and pyrrolcarbothioamides and their agrochemical uses
The invention relates to novel pesticidal pyrrolcarboxamide of the formula (I), wherein X is oxygen or sulfur; R 1 is CF 3 , CF 2 H or CFH 2 ; R 2 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7101893 |
(2-Carboxamido)(3-amino)thiophene compounds
A method of treatment of hyperproliferative disorders comprises administering an effective amount of a compound represented by Formula II:
or a pharmaceutically acceptable salt thereof.
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7098238 |
Degradation fragments
A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y 1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO 2 R 4 , —CO 2 R...
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7098222 |
Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
Compounds of formula (I)
wherein R 1 or R 2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L 2 and L 3 , to a heteroaromatic core, and X, X′,...
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7094791 |
Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in...
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7094801 |
Chalcone derivatives and their use to treat diseases
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7091235 |
Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
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7091204 |
Sulfonamides
The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
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7087638 |
Pyrrolecarboxamides and pyrrolethioamides as fungicides
Novel pyrrole derivatives of formula I
wherein
X is oxygen or sulfur; R 1 is C 1 –C 4 alkyl unsubstituted or substituted, with the exception of CF 3 ; C 3 –C 6 cycloalkyl unsubstituted or...
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7083801 |
Stabilized haloalkynyl microbicide compositions
Antimicrobial compositions based on haloalkynyl active ingredients that are chemically stable in the presence of chelated metal ion are disclosed. Particularly preferred is the use of metal ion...
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7084136 |
Drug composition antagonistic to both PGD2/TXA2 receptors
A compound of the formula (I):
wherein A is alkylene optionally having an unsaturated bond; R is —C(═O)—R 1 ; R 1 is hydroxy or the like; m is 0 or 1; p is 0 or 1; X 1 and X 3 are each...
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7078430 |
HMG CoA-reductase inhibitors
The invention relates to particular hydroxyl and protected hydroxyl derivatives of compounds known to be useful as HMG CoA-reductase inhibitors. In particular, herein are provided hydroxyl and...
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7078414 |
Derivatives of 3-guanidinocarbonyl-1-heteroaryl-pyrrole, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-pyrrole derivatives of formula (I) wherein R 1 to R 3 and Ar are as defined herein, pharmaceutical compositions comprising such...
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7074818 |
Crystalline forms VI and VII of Atorvastatin calcium
The present invention relates to novel crystalline forms of atorvastatin calcium and to the methods of their production and isolation. More specifically, the present invention relates to novel...
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7074785 |
Δ1-pyrrolines used as pesticides
Novel Δ 1 -pyrrolines of the formula (I)
in which
R 1 , R 2 , R 3 , A, R 4 and m have the meanings given in the description,
a number of processes for preparing these substances, and their...
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7067509 |
Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the...
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7060725 |
Substituted sulfamate anticonvulsant derivatives
The present invention is directed to novel compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, processes for the...
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7060722 |
Proline derivatives and use thereof as drugs
The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that...
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7056944 |
Pyrazole compositions useful as inhibitors of erk
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where R 1-4 , Q, and T are described in the specification. The compounds are useful for treating...
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7056935 |
Rotamase enzyme activity inhibitors
This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal...
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7056889 |
Compounds that bind P2Y2 or P2Y1 receptors
The invention provides peptides and compounds that can bind to P2Y 2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.
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7049323 |
Amidoheterocycles as modulators of the melanocortin-4 receptor
Novel azetidinyl and pyrrolidinyl compounds are ligands of melanocortin-4 receptors and are useful for treating conditions responsive to the modulation of melanocortin-4 receptors such as obesity,...
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7045535 |
Compounds useful for inhibiting paramyxovirus neuraminidase
Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:
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7034051 |
Fused bicyclic carboxamide derivatives and methods of their use
Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.
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7030151 |
Atorvastatin calcium in a pharmaceutical form composition thereof and pharmaceutical formulation comprising atorvastatin calcium
Atorvastatin calcium, the substance known by the chemical name (R—(R*,R*))-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-((phenylamino)carbon
yl)-1H-pyrrole-1-heptanoic acid hemi...
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7026357 |
Diphenylurea compounds
Compound of formula (I):
and medicinal products containing the same are useful as dual α 2 /5-HT 2c antagonist receptors.
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7026352 |
Physiologically active substances
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide...
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RE39049 |
Methods for inhibiting bone loss
The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse...
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7005442 |
8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
The present invention provides a compound represented by the general formula I;
wherein A, Ar, X, Z, n, x, y, R and R 3 are as defined in the specification.
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6992083 |
Benzoxazol derivatives
The invention relates to compounds of formula
wherein
R is phenyl, unsubstituted or substituted by halogen or —CH 2 N(CH 3 )(CH 2 ) n OCH 3 , or
is benzyl, lower alkyl, lower...
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6989384 |
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds,...
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6984637 |
Cyclic amine derivatives-CCR-3 receptor antagonists
This invention relates to certain cyclic amine derivatives of Formula (I)
that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods...
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6984656 |
Core modified porphyrins
The present invention is directed to novel photosensitive compounds that can be replicated with great certainty and provide applications for photodynamic therapy.
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6984658 |
Oligo/polysuccinimides, process for producing thereof and their use
The invention is directed to oligo/polysuccinimides prepared from alkyl or alkenyl succinic anhydride, containing two or more imide groups, a method for producing such oligo-polysuccinimides, and...
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6984651 |
Piperidine amides as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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6962942 |
Azacycloalkanone serine protease inhibitors
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
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6953793 |
Substituted pyrazoles
Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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