|
Match
|
Document |
Document Title |
|
|
5885985 |
Guanidine derivatives useful in therapy
Guanidine derivatives of formula I ##STR1## wherein R 8 represents hydrogen, halogen, alkyl C1 to 6, nitro, trifluoromethyl, thioalkyl C1 to 6, hydroxy, alkoxy C1 to 6, or a group selected from...
|
|
|
5883118 |
Prostatic carcinoma
The present invention provides novel uses of compounds of general formula I ##STR1## wherein R 1 , R 4 and R 5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl lower...
|
|
|
5874446 |
Benzopyran derivatives
Novel benzopyran and benzoxazine derivatives represented by the general formula: ##STR1## wherein R 1 and R 2 represent a lower haloalkyl group, R 3 represents a hydrogen atom, etc., R 4 ...
|
|
|
5869478 |
Sulfonamido substituted benzopyran derivatives
|
|
|
5869520 |
Carbamoyloxylabdanes
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions...
|
|
|
5869067 |
Bi-aromatic compounds and pharmaceutical and cosmetic compositions
The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
|
|
|
5866424 |
Stable liquid urobilinogen control composition
The present invention addresses the need to ensure that clinical tests for urobilinogen in urine are properly working. The invention specifically provides a novel liquid urobilinogen composition...
|
|
|
5861429 |
13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests
Compounds of formula (I): ##STR1## wherein: R 1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is C(R 2 ) 2 or C(CH 2 ) m , in which R 2 is alkyl, and m is...
|
|
|
5858402 |
Methods for in vivo reduction of cyanide levels and compositions useful therefor
In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in...
|
|
|
5859046 |
Biologically active oreido derivatives useful in the treatment of multiple sclerosis
Use, in the preparation of a medicament for use in the treatment of multiple sclerosis, of a compound which is a ureido derivative of formula (I) ##STR1## wherein each of m and n, which are the...
|
|
|
5859042 |
Five membered heterocyclic compounds
The instant invention is related to 5-membered heterocyclic compounds and pharmaceutical compositions which possess inhibitory activity on 5 alpha-reductase.
|
|
|
5859045 |
Crystalline -! 3R 4R-trans-7 methoxy 2,2-dimethyl1-3-phenyl 1-4 4-12 pyrrolidin-1 -Y1!ethoxyl 1!chromane hydrogen fumarate
The present invention provides novel crystalline (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4- 2-(pyrrolidin-1-yl)e thoxy!phenyl}chromane, hydrogen fumarate useful for reducing or...
|
|
|
5856341 |
Benzo B! indeno 2,1-D! thiophene compounds, intermediates, processes, compositions and methods
The invention provides benzo b!indenothiophene compounds of formula I ##STR1## wherein, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , are as defined in the specification, intermediates, formulations, and...
|
|
|
5852051 |
Dipeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals
Compounds of the formula I ##STR1## in which R 1 , A and B have the meanings stated in the description, and the preparation thereof are described. The novel compounds are suitable for controlling...
|
|
|
5849798 |
Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'--...
|
|
|
5849776 |
Medicaments based on metronidazole or on a synergic mixture of metronidazole and clindamycin
The invention relates to the use of metronidazole, or preferably of a combination of metronidazole and clindamycin, as active principle for the manufacture of pharmaceutical compositions, more...
|
|
|
5849733 |
2-thio or 2-oxo flavopiridol analogs
Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and n are as defined in the disclosure. The compounds of formula...
|
|
|
5849755 |
3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them
3-amidochromanylsulfonyl(thio)ureas of the formula (I): ##STR1## which are valuable pharmaceutically active compounds for the treatment of disturbances of the cardiovascular system, in particular...
|
|
|
5843982 |
Fungicidal compositions comprising metalaxyl and fludioxonil
When used in admixture with fludioxonil, metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly enhanced fungicidal action against plant...
|
|
|
5843962 |
Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism
A method of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1##...
|
|
|
5843940 |
Benzothiophene compounds, compositions, and method
The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions...
|
|
|
5843959 |
Methods and bicyclic polyamine compositions for the treatment of inflammation
Methods for treating inflammatory conditions wherein the active agent is a polyamine having the formula set forth below: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein:...
|
|
|
5837720 |
N-2-(pyrrolidinyl-1)-1-phenethyl) acetamides as kappa receptor antagonists
A compound of formula (I): ##STR1## and its pharmaceutically acceptable salt, wherein R is hydrogen or hydroxy; Ar is unsubstituted or substituted phenyl; X is unsubstituted or substituted phenyl...
|
|
|
5837724 |
Method of enhancing cognition
Darifenacin, and its pharmaceutically acceptable salts, are useful in the treatment of cognitive impairment. The invention also discloses the use of combinations of darifenacin, or a...
|
|
|
5837702 |
4-arylamino-benzopyran and related compounds
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH 2 --, --C(O)--, --O--, --S-- or --N(R 8 )-- where R 8 is hydrogen,...
|
|
|
5834460 |
Serine derivative
A serine derivative represented by the general formula (I) ##STR1## (symbols in the formula represent the following meanings; X: a sulfur atom or an oxygen atom, Y: a nitrogen atom or CH, R 1...
|
|
|
5834488 |
Dihydrobenzo B! indeno 2, 1-D! thiophene compounds, intermediates, processes, compositions and methods
The invention provides dihydrobenzo b!indenothiophene compounds, intermediates, processes, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis,...
|
|
|
5830869 |
Thiadiazole amide MMP inhibitors
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase...
|
|
|
5827876 |
Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo b!-thiophenes
This invention relates to 3-(4-acrylamidobenzoyl)benzo b! thiophenes, to the process for their preparation, to pharmaceutical compositions and to their use for modifying the balance between bone...
|
|
|
5827875 |
Inhibitors of microsomal triglyceride transfer protein and method
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the...
|
|
|
5827844 |
Lipophilic benzothiophenes used for treating endometriosis
The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R 1 is N-pyrrolidinyl or N-piperidinyl; R 2 and R 3 are independently hydrogen, --CO--(C 10 -C 22 alkyl),...
|
|
|
5824650 |
Topical composition containing a substance P antagoinst
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating...
|
|
|
5821263 |
Sulfenamide taxane derivatives
This invention provides a novel series of taxane derivatives which are characterized by the C3' nitrogen bearing one or two sulfur substituents. The new derivatives are antitumor agents useful in...
|
|
|
5817324 |
Use of arylpyrroles for the control of resistant insect populations
There is provided a method for the control of pyrethroid-resistant insects and the protection of animals therefrom which comprises contacting said insects with a toxic amount of a formula I...
|
|
|
5811448 |
Substituted chromanysulfonyl (thio) ureas, processing for their preparation and pharmaceutical uses thereof
Substituted chromanylsulfonyl(thio)ureas, processes for their preparation, their use in pharmaceutical preparations, and pharmaceutical preparations comprising them Chromanylsulfonyl(thio)ureas of...
|
|
|
5804595 |
Kappa opioid receptor agonists
The invention provides certain amino acid conjugates of substituted 2-phenyl-N- 1-(phenyl)-2-(1-heterocycloalkyl- or heterocycloaryl-)ethyl!acetamides useful for selectively agonizing kappa opioid...
|
|
|
5792763 |
Serotonin 5-HT.sub.1F agonists
This invention provides novel 5-HT 1F agonists of formula ##STR1## where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and...
|
|
|
5789405 |
Oxaspiro(2,5)octane derivative
An oxaspiro 2,5!octane derivative of the formula: ##STR1## useful in inhibiting angiogenesis in solid tumors.
|
|
|
5780502 |
Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
The present invention provides novel uses of compounds of general formula I ##STR1## wherein R 1 , R 4 and R 5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, C 1 -6 alkyl, C 1 -6...
|
|
|
5770612 |
Methods of treating menstrual symptoms and compositions there for
The present invention provides a method of alleviating one or more menstrual symptoms in a woman comprising administering to said woman in need of treatment an effective amount of a compound having...
|
|
|
5767116 |
Bicyclic aromatic compounds as therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or --O--; B is methylene or --O--; and g is 0, 1, 2, 3 or 4; R 1 , R 2 , R 3 , R 4 , U, Q...
|
|
|
5760030 |
Benzothiophene compounds and methods of use
The instant invention provides novel benzothiophene compounds, pharmaceutical formulations, and methods of use.
|
|
|
5756539 |
3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders
A method of inhibiting one or more psychiatric disorders is disclosed comprising administering a compound of formula I ##STR1## wherein R 1 , R 4 and R 5 are individually hydrogen, hydroxy,...
|
|
|
5753691 |
Agents for inhibiting the production of IL-1β and the release of TNFα
The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1β and the release of TNFα. Those derivatives are useful in the treatment...
|
|
|
5753629 |
Distamycin A analogues as antitumour or antiviral agents
The present invention relates to compounds of formula (I) ##STR1## The compounds of the invention are useful as antitumor or antiviral agents.
|
|
|
5741799 |
Heterocyclic thrombin inhibitors
Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R 1 , R 2 , R 3 , G, G x , R 6 ', Ra, Xa, R 6 , Rb, R 3 , p, Q, A and R 4 are as defined herein.
|
|
|
5739155 |
Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents
Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the control of insects and acarids are described. A method for the insecticidal and acaricidal use of said...
|
|
|
5731328 |
Methods of inhibiting plasminogen activator inhibitor 1
A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are...
|
|
|
5726202 |
Benign prostatic hypertrophy
The present invention provides novel uses of compounds of general formula I ##STR1## wherein R 1 , R 4 and R 5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower...
|
|
|
5726195 |
Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1- 5- 4- (5-nitro-2-thienyl)ethynyl!ph...
|