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7635712 |
Salinosporamides and methods for use thereof
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
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7629376 |
3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I
The present invention discloses and claims compounds of formula (I) and formula (II)
as inhibitors of human casein kinase Iε, and methods of using the compounds of formula (I) and formula (II)...
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7579371 |
Methods of using [3.2.0] heterocyclic compounds and analogs thereof
Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a...
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7572606 |
Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve,...
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7544814 |
[3.2.0] Heterocyclic compounds and methods of using the same
Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their...
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7514468 |
Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to indolinone derivatives substituted in the 6 position of general formula
wherein
R 1 to R 6 and X are defined as in claim 1 , the tautomers, enantiomers,...
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7514466 |
Purification of progesterone receptor modulators
Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R 1 are defined herein.
The methods include mixing the compound of formula I and a solvent; adding a base to...
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7442804 |
Process for the preparation of furopyrroles
The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally...
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7419975 |
Organic compounds
Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7199081 |
Aqueous compositions for seed treatment
An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight:
a) 2–10% of a...
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7179834 |
Salinosporamides and methods for use thereof
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
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7081464 |
Topical compositions of cyclic amides as immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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6835719 |
Pesticidal composition
An environmentally safe pesticidal liquid suspension composition including a mixture of sulfur combined with pyrethrins and/or pyrethroids is provided. The pesticidal composition is effective to...
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6780887 |
Anti-ischemic compounds
The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating...
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6677317 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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6677310 |
Ring-expanded nucleosides and nucleotides
The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded (“fat”) heterocyclic ring, in place of purine, and an unmodified or modified...
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6583144 |
Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same
Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can...
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6583171 |
Antineoplastic agents
Compounds, isolated from the bacteria Xenorhabdus bovienil , have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing...
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6583170 |
2-Phenyl-1-&lsqb 4-(amino-1-yl-alk-1-ynyl)-benzyl&rsqb -1H-indol-5-ol and estrogen formulations
The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol compounds which are useful as estrogenic agents,...
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6518281 |
Immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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6492366 |
Cyano-indole serotonin-reuptake inhibitor compound
A compound selected from those of formula (I): wherein: R 1 and R 2 each independently represent hydrogen or, alkyl, T 1 and T 2 each independently represent alkylene, G represents a...
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6458825 |
Lactacystin analogs
Compounds related to lactacystin and lactacystin lactone, pharmaceutical compositions containing the compounds, and methods of use.
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6451841 |
Method of diffusing an acaricidal composition comprising permethrin and tetramethrin, and the use of a catalytic combustion flask for implementing such a method
The invention relates to a method of combating insects and parasites, and in particular acarids, the method comprising a step of diffusing a composition that includes permethrin in a solvent. The...
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6441019 |
Cyclocarbamate and cyclic amide derivatives
This invention provides compounds of the formula: wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N;...
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6395764 |
2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists
This invention involves compounds having the following structure: wherein: a) R 1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R 2 and R 3 are each independently selected...
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6365608 |
Fungicide mixtures based on pyridine carboxamides
Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR 1 R 2 I in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered...
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6355668 |
Bicycloloactam compounds, use thereof and intermediates for preparing thereof
A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly...
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6288104 |
Pharmaceutical compositions containing mesembrine and related compounds
There is disclosed the use of mesembrine and related compounds (e.g. mesembranol, mesembranone) as scrotonin-uptake inhibitors, pharmaceutical compositions comprising such compounds or dry material...
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6271199 |
Treatment of infarcts
This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-κB via the ubiquitin...
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6218421 |
Method of promoting smoking cessation
A method for promoting smoking cessation, which method comprises administrating an effective, non-toxic amount of ropinirole or a pharmaceutically acceptable salt or solvate thereof to a human in...
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6201008 |
Pesticidal composition
The present invention provides a pesticidal composition which comprises 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluromethylpy
rrole-3-carbon itrile and at least one pyrethroidal compound as...
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6158438 |
Model of heart failure
A method of chronically instrumenting an animal enabling one to simulate congestive heart failure. This invention also relates to method for assessing the effects of a test compound on cardiac...
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6160003 |
1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically...
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6130241 |
Insect-repellent formulations
The invention provides an insect- or acarid-repellent formulation comprising a compound of formula (I), wherein R represents straight or branched chain C 2 -10 alkyl, straight or branched chain C 2...
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6121306 |
Method of making (1S, 4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R, 4S), 1-azabicyclo[2.2.1]heptan-3-one
Racemic (±)-1-azobicyclo[2.2.1]heptan-3-one may be efficiently resolved into its (1S,4R)- and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one isomers by formation of di-p-toluoyl hemitartrate salts by...
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6075044 |
Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases
The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.
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6042842 |
Cosmetic composition comprising a novel pigment
The present invention relates to cosmetic compositions, in particular make-up cosmetic compositions, comprising a novel red pigment with an intense and saturated color which does not generate free...
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6020360 |
Anticancer property of dithiolopyrrolones
The invention is drawn to a novel use of a group of known compounds with the formula shown below, ##STR1## wherein R 1 , R 2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl,...
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5990105 |
Benzosulfone derivatives
The present invention relates to novel compounds of the general formula ##STR1## wherein R 1 is hydrogen; R 2 is hydrogen, trifluoromethyl or lower alkyl; R 3 is hydrogen or amino; or R...
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5962503 |
Use of cholinesterase inhibitors in the treatment of xerostomia
There is provided the use of a cholinesterase inhibitor in the manufacture of a medicament for topical administration for use in the treatment of xerostomia
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5927283 |
Allosteric modifiers of hemoglobin
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including...
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5906207 |
Method for simulating heart failure
A method of chronically instrumenting an animal enabling one to simulate congestive heart failure. A method for assessing the effects of a test compound on cardiac function and systemic vascular...
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5866582 |
Fungicidal combination of a dicarboximide compound and cyprodinil
Fungicidal combination comprising a compound A which is iprodione, vinclozoline or procymidone, and a compound B which is cyprodinil, also known as 2-phenylamino-4-cyclopropyl-6-methylpyrimidine,...
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5843981 |
Method for killing dust mites and preventing associated allergies
A mixture of a pyrethrin, a pyethroid, and one or more synergists is applied to dust mites in a substrate, such as carpeting, in order to kill the dust mites.
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5827872 |
Xenomins novel heterocyclic compounds with antimicrobial and antneoplastic properties
The invention is drawn to novel antibiotics, xenomins of the formula shown below, ##STR1## wherein R 1 =hydrogen; R 2 =an unsubstituted acyl group; R 3 =hydrogen or alkyl, produced by...
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5776970 |
Tryptophan derivatives as protein tyrosine kinase blockers and their use in the treatment of neoplastic diseases
Tryptophan derivatives substituted by a hydrophobic group, e.g. carbobenzoxy, at the N-terminus, and a hydrophilic group, e.g. --COOH, --SO 3 H or --PO 3 H, at the C-terminus, were found to be...
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5767128 |
1,3-dihydro-2H-pyrrolo 2,3-b!pyridin-2-one compounds
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , W and Y are as defined in the description, its geometric and/or optical isomers, and its...
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