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7553865 |
Indomethacin external preparation
An object of the present invention is to provide an indomethacin external preparation that has an excellent use feeling and excellent absorbability and causes no phase separation into an oil layer...
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7550624 |
Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same
Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol,
and methods of using the same...
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7491744 |
Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet...
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RE40546 |
1,3-Propane diol esters and ethers and methods for their use in drug delivery
The invention relates to compounds of formula:
wherein R 1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon...
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7417035 |
Phospholipid derivatives of non-steroidal anti-inflammatory drugs
Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the...
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7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7182942 |
Vaccine immunotherapy for immune suppressed patients
A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide...
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7153499 |
Vaccine immunotherapy for immune suppressed patients
The present invention provides a formulation for inhibiting metastasis which includes 150–600 units of IL-2, a nonsteroidal anti-inflammatory drug (NSAID), and cyclophosphamide. The present...
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7115647 |
Method of inhibiting neoplastic cells with indole derivatives
A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
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7045531 |
Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
The invention relates to the identification of pharmacological agents to be used in the treatment of Alzheimer's disease and related pathological conditions. Methods and compositions for treatment...
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6911466 |
Aβ42 lowering agents
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ 42 lowering agent to a mammal under conditions in which levels...
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6867236 |
Method of preventing of delaying the onset and progression of Alzheimer's disease and related disorders
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of...
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6762182 |
Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
A method of altering specificity of cyclooxygenase-inhibiting compounds that have a COOH moiety by changing the various COOH containing compounds, such as indomethacin, into ester derivatives or...
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6730329 |
Zinc containing compositions for anti-viral use
One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one...
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6686388 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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6683112 |
Gabapentin prodrugs and formulations
The present invention relates to novel prodrugs of gabapentin and to pharmaceutical formulations and sustained release formulations containing the prodrugs.
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6667310 |
Substituted guanidine derivatives
The present application provides guanidine derivatives of the formula (I) wherein R 1 , R 2 , R 3 , A and Z are as defined herein.
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6620853 |
Methods and compositions for prevention and treatment of restenosis with non-steroidal anti-inflammatory drugs
Methods and compositions for the prevention and/or treatment of vascular restenosis, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal...
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6620813 |
Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and...
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6566346 |
Oral skin improving agent, skin improving method, and food composition for improving skin
There are provided an oral skin improving agent that exhibits good skin improving effects when orally ingested, suppresses problems of discoloration and generation of unpleasant odor during...
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6444665 |
Method for treating pain
The present invention provides a method for treating pain using an atypical antipsychotic compound.
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6420394 |
Topically applied pharmaceutical formulation
The present invention relates to a novel pharmaceutical formulation for the topical application of drugs, particularly non-steroidal anti-inflammatory drugs (NSAID's), comprising a therapeutically...
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6399647 |
Amide derivatives for antiangiogenic and/or antitumorigenic use
A method of treating animals having cancer by administration of secondary amide derivatives of various COOH-containing drugs, such as COOH-containing NSAIDs, for instance, indomethacin.
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6323218 |
Agents for use in the treatment of Alzheimer's disease
The invention relates to the identification of pharmacological agents to be used in the treatment of Alzheimer's disease and related pathological conditions and compositions for treatment of...
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6235770 |
Indolyl-substituted phenylacetic acid derivatives
The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives...
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6204245 |
Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one...
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6180601 |
Low molecular weight hyaluronic acid with peptide or protein
The invention relates to freeze-dried soft, flexible and continous matrix of low-molecular weight hyaluronic acid or salt thereof, in which the molecular weight of the hyaluronic acid is preferably...
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6160018 |
Prophylactic composition and method for alzheimer's Disease
A method of preventing or delaying the onset of symptoms of Alzheimer's Disease includes the step of administering to a patient in need of such treatment a composition having an effective...
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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6063807 |
Cyclo-oxygenase inhibitor and amidine derivatives salts, preparation method therefor, use thereof as drugs, and pharmaceutical compositions containing said salts
Cyclo-oxygenase inhibitor and amidine derivative salts, preparation methods therefor, pharmaceutical compositions containing said salts and the use thereof particularly as NO synthase and...
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6051566 |
Anti-reactive anti-asthmatic activity of non-steroidal anti-inflammatory drugs by inhalation
Non-steroidal anti-inflammatory drugs proved to be effective drugs for combating and preventing asthma if administered by inhalation. Useful are for instance acetylsalicylic acid, and indomethacin,...
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6011055 |
Treatment of cystic disease with compounds which stimulate TNF-α production in vivo
A method for treating polycystic kidney disease in an individual in need thereof. This method includes identifying a mammal having a cystic disease and administering to the mammal a...
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5985860 |
System for transdermal delivery of pain relieving substances
Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other...
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5981555 |
Compositions, kits and methods for administration of antilipemic drugs
The present invention concerns composition, kits and methods for reducing the flushing effect (cutaneous erythema) of an antilipemic drug, for treating hyperlipemia, for improving the effectiveness...
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5952367 |
Method of treating pain cause by bursitis tendinitis arthritis
Disclosed herein is a method of treating pain caused by bursitis, tendinitis, arthritis, and the like, comprises ingesting an effective amount of a non-steroidal anti-inflammatory drug, and...
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5939455 |
Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
This invention provides a method of augmenting the therapeutic activity of an oxyalkylene-containing compound, butyric acid, a butyric acid salt or butyric acid derivative by administering an...
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5929095 |
Method of inhibiting secretory effects caused by Cholera
The administration of the PAF antagonists BN 52021 and SR 27417, in combination with cyclooxygenase antagonist indomethacin are disclosed as effective in inhibiting the secretory effects caused by...
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5908848 |
Synergistic composition of codine and ibuprofen to treat arthritis
The invention relates to the use of a non-steroidal anti-inflammatory drug together with an opioid analgesic in the manufacture of a medicament for the treatment of arthritis.
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5811410 |
Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
A method of administering a medicinal agent and an effective amount of a form of hyaluronic acid for decreasing side effects associated with using the agent alone in treating a disease or condition...
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5792786 |
Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof
The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably...
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5773453 |
Methods for administration of antilipemic drugs
The present invention concerns methods for reducing cutaneous flushing in a patient to whom niacin is administered. According to the present method, two or more doses of a nonsteroidal...
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5763452 |
Pharmaceutical compositions and usages
The invention relates to the use of a non-steroidal anti-inflammatory drug together with an opioid analgesic in the manufacture of a medicament for the treatment of arthritis.
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5747521 |
N-cinnamoyl-2-methyl-5-methoxy-3-indoleacetic acid ester, and pharmaceutical preparation containing the same
The present invention relates to a new N-cinnamoyl-2-methyl-5-methoxy-3-indoleacetic ester represented by the following general formula (I). It is manufactured by causing...
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5736536 |
Method for treating vascular leak syndrome
A novel method for preventing, stabilizing or causing regression of vascular leak syndrome is disclosed. The method comprises administering to a patient in need thereof a compound selected from the...
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5674888 |
Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
The invention concerns the recognition that certain non-steroidal anti-inflammatory agents can overcome or ameliorate limitations on trabecular meshwork cell division produced by environmental...
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5663192 |
Heterocyclic neuropeptide Y receptor antagonists
This invention provides methods for treating or preventing a condition associated with an excess of neuropeptide Y which methods comprise administration of one or more substituted benzofurans,...
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5650394 |
Use of urinastatin-like compounds to prevent premature delivery
The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by...
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5643960 |
Method of delaying onset of alzheimer's disease symptoms
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The method involves the administration to...
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5621005 |
Aqueous pharmaceutical suspension for substantially water insoluble pharmaceutical actives
The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a...
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