|
Match
|
Document |
Document Title |
|
|
8168669 |
Therapeutic agent for inflammatory bowel disease and TNF-α production inhibitor
Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent ...
|
|
|
8143259 |
Cold menthol receptor antagonists
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein...
|
|
|
8143291 |
Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity
The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1-phosphate agonists or antagonists. As such, the compounds described herein are useful...
|
|
|
8138221 |
Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture
The present invention relates to pharmaceutically acceptable crystalline and amorphous salts of D-isoglutamyl-D-tryptophan as well as processes for their manufacture, pharmaceutical compositions...
|
|
|
8124585 |
Composition for relieving discomfort
The invention relates to a method of controlling feelings of pain in infants or diseased or elderly persons using a complete nutrition or a nutritional supplement. The method comprises...
|
|
|
8114440 |
Pharmaceutical compositions for the administration of aptamers
Pharmaceutical compositions comprising an aptamer and an amino acid ester or amide or an aptamer; a divalent metal cation; and a carboxylic acid, a phospholipid, a phosphatidyl choline, or a...
|
|
|
8101649 |
N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors
This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the...
|
|
|
8097645 |
Compounds for activating TGF-β signaling
Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described.
|
|
|
8092840 |
Dietary supplement and a method to enhance sleep and lucid dreaming
A nutritional supplement for enhancing sleep and lucid dreaming in humans. It contains a combination of ingredients in proportions calculated to enhance lucid dreaming. The primary ingredients are...
|
|
|
8093253 |
Leukotriene B4 inhibitors
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
|
|
|
8088800 |
4-(5-aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity
The present invention relates to compounds of formulae (I) and (II) useful as opioid receptor antagonists for the treatment of obesity, wherein p is 0, 1, or 2; y is 0, 1, or 2; and z is 0, 1, or...
|
|
|
8067401 |
Compounds and compositions for treating infection
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
|
|
|
8067416 |
Methods and compositions for the treatment of metabolic disorders
The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the specification describes methods and...
|
|
|
8063094 |
Anti-cytokine heterocyclic compounds
Heterocyclic compounds which are inhibitors of Mitrogen-Activated Protein Kinase-Activated Protein Kinase-2 (MAPKAP-K2) as described, in addition to their use in the treatment of cytokine mediated...
|
|
|
8044091 |
Phospho-indoles as HIV inhibitors
3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in...
|
|
|
8026271 |
Formulations of indol-3-yl-2-oxoacetamide compounds
This invention relates to an oral formulation containing an effective amount of the compound of the following formula I: d-alpha-tocopheryl polyethylene glycol 1000 succinate (“TPGS”); and 2-(...
|
|
|
8021681 |
Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
The present invention is directed to a method of treating a patient suffering from the metabolic syndrome and/or related disorders including obesity, Type 2 diabetes, pre-diabetes, hypertension,...
|
|
|
8017159 |
Phospholipid gel compositions for delivery of aptamers and methods of treating conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an...
|
|
|
8017645 |
Melatonin daily dosage units
The present invention relates to a disposable container for a medicament or cosmetic agent for topical application, containing a single dose of melatonin or of a melatonin derivative which...
|
|
|
8008295 |
Tyrosine kinase inhibitors
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The...
|
|
|
8003682 |
Indole compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group,R2 represents a linear or branched (C1-C6)alkyl group,and n represents from 1 to 6. Medicaments.
|
|
|
7998698 |
Method for predicting susceptibility to radiation pneumonitis
Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of...
|
|
|
7993666 |
Methods and compositions for treating pain comprising a statin
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a...
|
|
|
7989487 |
Estrogen receptor modulators and uses thereof
A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a...
|
|
|
7985764 |
Amide derivative or salt thereof
It was found that a compound according to the following formula: or a pharmaceutically acceptable salt thereof, has a strong antagonism for both the 5-HT2B and 5-HT7 receptors. In addition, the...
|
|
|
7977380 |
Inhibitors of plasma kallikrein
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
|
|
|
7973070 |
Monatin hydrate crystals
New (2R,4R) monatin monosodium salt hydrate crystals characterized by having specific characteristic X-ray diffraction peaks provide general-purpose, stable, and safe monatin sodium salt crystals...
|
|
|
7964629 |
Inhibitors of isoprenylcysteine carboxyl methyltransferase
The present invention relates, in general, to isoprenylcysteine carboxyl methyltransferase (Icmt) and, in particular, to inhibitors of Icmt and to methods of disease treatment using same.
|
|
|
7960428 |
Enantiomerically pure phosphoindoles as HIV inhibitors
3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided...
|
|
|
7960427 |
5-hydroxyindole-3-carboxylate derivatives and uses thereof
The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof,...
|
|
|
7956067 |
Composition comprising at least one higher aliphatic alcohol and an extract of Griffonia simplicifolia
Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of...
|
|
|
7951835 |
Crystals of non-natural-type stereoisomer salt of monatin and use thereof
The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
|
|
|
7951834 |
Angiotensin I-converting enzyme (ACE) inhibitors
This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via...
|
|
|
7943658 |
Indole indane amide compounds useful as CB2 agonists and method
Indole indane amides which are CB2 agonists are provided which have the structure wherein R1, R2, R3, R4 and R5 are as defined herein, which compounds are useful in treating autoimmune diseases,...
|
|
|
7939558 |
Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein...
|
|
|
7935377 |
Crystals of free (2R, 4R)-monatin and use thereof
A crystal of free (2R,4R)-monatin is useful as a sweet substance. The crystals resist absorption of water even under high humidity, are stable and exhibit a high degree of sweetness. Thus, such...
|
|
|
7928137 |
Meta-benzamidine derivatives as serine protease inhibitors
Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted...
|
|
|
7919519 |
S1P receptor modulating compounds and use thereof
The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with...
|
|
|
7902250 |
Compositions based on aminoacids, suitable for the treatment of heart failure
Compositions based on amino acids are described, in particular for oral or parenteral use, suitable for treating heart insufficiency. The compositions according to the invention comprise up to 75%...
|
|
|
7902251 |
Method for treating pain
The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the...
|
|
|
7897160 |
Conjugated fatty acid based emulsion and methods for preparing and using same
Stable emulsions comprising as a base one or more diene conjugated fatty acids. Amino acids and other macromolecules can be used to stabilize the emulsion. The emulsion is also useful as a carrier...
|
|
|
7888383 |
Organic compounds
There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, D, X, W, m and n are as described in the specification, process for...
|
|
|
7888384 |
Heterocyclic derivatives for modulation of calcium channels
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
|
|
|
7872040 |
Receptor blocker and vasodilator comprising indole derivative as active ingredient
It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine. The present invention...
|
|
|
7863335 |
Non-antibiotic intervention of chlamydial infection
Methods for treating or reducing the risk of transmission of chlamydia to a recipient by topically applying a metalloprotease inhibitor to a site on the recipient which is likely to be exposed to...
|
|
|
7863315 |
2-indolinone derivatives as selective histone deacetylase inhibitors
Provided herein are isolated compounds of formula I: processes for their preparation and isolation, as well as pharmaceutical compositions which comprise these therapeutic agents, and methods of...
|
|
|
7855225 |
17βHSD type 5 inhibitor
To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal...
|
|
|
7838548 |
Compounds and methods for treating toll-like receptor 2-related diseases and conditions
The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
|
|
|
7816394 |
Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same
Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin...
|
|
|
7803835 |
Substituted acetic acid derivatives
The present invention relates generally to substituted acetic acid derivatives and methods of using them.
|