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7618650 |
Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
The invention concerns the combination of a short-acting hypnotic agent and a compound of formula (I):
Wherein X, Y, Z, A, B, D, Ar, R 1 and R 2 are as defined herein. The combination of this...
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7615572 |
Pyrrole and pyrazole DAAO inhibitors
Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia,...
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7612089 |
Tetrahydroisoquinolines as factor Xa inhibitors
The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
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7608633 |
Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2
The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A 2 , pharmaceutical preparations containing these compounds and a method of...
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7601751 |
Indole acetic acid acyl guanidines as β-secretase inhibitors
There is provided a series of substituted acyl guanidines of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and...
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7598287 |
Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the administration of an additional therapeutic...
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7572824 |
Methods for minimizing thioamide impurities
Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are...
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7572823 |
Heteroaryl carboxamide compounds
Compounds of formula I
their manufacture, pharmaceutical compositions containing them and their use as medicaments.
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7566736 |
Substituted indoles, compositions containing them, method for the production thereof and their use
Compounds of formula (I):
wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them,...
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7560591 |
Benzamidine derivatives having anti-inflammatory and immunosuppressive activity
Compounds which can be represented by the general formula (I) indicated below:
and in which:
A is selected independently from the carboxamide group, the thiocarboxamide group, and the...
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7560481 |
Indoles are cannabinoid receptor ligands
The present invention provides novel compounds of Formula (I)
which are CB 2 selective ligands useful for the treatment of pain.
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7557114 |
Heterocyclic-substituted phenyl methanones
The present invention relates to compounds of formula I
wherein R 1 and R 2 are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Compounds of the...
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7553974 |
Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same
Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2θ of 5.5°, 7.2°, 8.1°, 8.9°, and 16.3°, by...
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7550501 |
Compounds and methods for treating toll-like receptor 2-related diseases and conditions
The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
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7547723 |
Comprehensive pharmacologic therapy for treatment of a dysfunction
The comprehensive pharmacologic therapy for treatment of obesity is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or Phentermine in combination...
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7534897 |
Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. ...
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7534809 |
Phospho-indoles as HIV inhibitors
3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in...
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7531670 |
Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives
Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the...
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7531568 |
PPAR active compounds
Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα,...
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7524878 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
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7488747 |
Pyrrole and pyrazole DAAO inhibitors
Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia,...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7476690 |
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of...
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7459478 |
Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
Compounds of formula (I) and II) are provided
wherein: X is an alkali metal or a basic amine moiety; R 1 is alkyl, cycloalkyl, —CH 2 -cycloalkyl, pyridinyl, —CH 2 -pyridinyl, phenyl or...
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7456296 |
Method for preparation of crystalline perindopril erbumine
A process for preparation of crystalline perindopril erbumine of formula (II)
which exhibits the X-ray (powder) diffraction pattern like that shown in FIG. 2
The process comprises reacting...
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7456209 |
IAP binding compounds
IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in...
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7449489 |
Indolylalkylamino-methylidenecarbamate derivatives useful as GnRH antagonists
The invention relates to a group of novel indole compounds of Formula (I): wherein: R 1 , R 2 , R 4 , R 6 , R 6a , R 7 , R 8 , R 9 , R 10 , and A are as defined in the specification, which are...
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7449459 |
Inhibitors of soluble adenylate cyclase
The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
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7442805 |
Substituted sulfonamide-indoles
The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.
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7429612 |
Indoline compound and medicinal use thereof
The present invention provides an indoline compound represented by the formula (I)
wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and a...
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7429611 |
Indole inhibitors of 15-lipoxygenase
The present invention provides indole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds...
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7427619 |
Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
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7419998 |
Therapeutic methods and compositions involving isoflavones
Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R 1 is H, or R A CO where R A is...
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7419992 |
Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders
A method of treating angiogenesis-implicated disorders by selecting a subject predisposed to an angiogenesis-implicated disorder and then administering an effective amount of an endogenous aryl...
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7402604 |
Positive modulators of nicotinic receptor agonists
Compounds according to formula I:
wherein R 1 , W, R 2 , R 3 , X, R 4 and R 5 are as described in the specification, enantiomers thereof, pharmaceutically acceptable salts thereof, processes...
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7384979 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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7384973 |
Materials and methods for treating hypercholesterolemia
The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive...
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7384972 |
Phytochemicals for treatment of endometriosis
New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′diindolylmethane...
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7384971 |
Phytochemicals for the treatment of cervical dysplasia
New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′diindolylmethane...
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7384945 |
Indole or benzimidazole derivatives as CB1 inverse agonists
Provided are compounds of the formula I:
and pharmaceutically acceptable salts thereof, processes for making said compounds and pharmaceutically acceptable salts thereof, pharmaceutical...
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7368471 |
Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
This invention provides compounds of the formula:
wherein: X is a chemical bond, —CH 2 — or —C(O)—; R 1 is alkyl, cycloalkyl, —CH 2 -cycloalkyl, pyridinyl, —CH 2 -pyridinyl, phenyl...
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7365091 |
Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX
The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula:
useful as inhibitors of PHEX. These derivatives are...
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7365061 |
2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
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7361682 |
Indole derivatives as H3 inverse agonists
The present invention relates to compounds of formula I:
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof,...
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7361681 |
Method of treating amytrophic lateral sclerosis using melatonin
The present invention relates to the treatment of amyotrophic lateral sclerosis (ALS) and/or the improvement of motor function in individuals in need of such improvement using a melatonin compound...
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7348354 |
Cyclohexylurea compounds
Cyclohexylurea compounds corresponding to formula I
a method for producing them, pharmaceutical compositions containing them, and the use of such compounds as pharmaceutically active agents...
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7348353 |
Acetylene derivatives having mGluR 5 antagonistic activity
The invention provides compounds of formula (I) wherein m, n, A, R, R′, R″, R 0 , X and Y are as defined in the description, and their preparation. The compounds of formula (I) are useful as...
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7345085 |
Indoles having anti-diabetic activity
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that...
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7345068 |
Aromatic amino acid derivatives and medicinal compositions
1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt:
wherein,
R 1 is a hydrogen atom or an amino-protecting group, R 2 is a...
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7332521 |
Substituted indoles
The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them.
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