|
Match
|
Document |
Document Title |
|
|
6541503 |
Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors
Compounds of formula (I): wherein X is N, CH, CCF 3 , or C(C 1-12 aliphatic); R 4 is sulfonic acid, C 1-12 aliphatic-sulfonyl, sulfonyl-C 1-12 aliphatic, C 1-12 aliphatic-sulfonyl-C 1-6 ...
|
|
|
6531467 |
Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing...
|
|
|
6528506 |
Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viablility of an organ for transplantation, and enhancing...
|
|
|
6503543 |
Tryptophan source from plants and uses therefor
Compositions are described comprising at least partially defatted meal from a plant source naturally containing tryptophan, preferably squash seeds, and a carbohydrate source provided in an amount...
|
|
|
6500841 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
|
|
|
6500854 |
Chondrongenesis promotors and indolin-2-one derivatives
A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: wherein R 1 represents a halogen atom, a lower alkyl group, a lower...
|
|
|
6489353 |
C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of...
|
|
|
6479493 |
Methods for treatment of type I diabetes
Substituted condensation products of -benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of type I diabetes.
|
|
|
6469044 |
Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
A method of treating a patient suffering from a dependence on, tolerance of, or addiction to at least one benzodiazepine comprises administering melatonin to said patient on a daily basis in an...
|
|
|
6465516 |
Method of stimulating nitric oxide synthase
A method for treating a subject who would benefit from increased nitric oxide production comprising administering inhibitors of Hmg-CoA-Reductase is disclosed for the treatment of diseases related...
|
|
|
6455569 |
Connective tissue softening
The use of Matrix Metalloproteinase Inhibitors in the prevention or treatment of connective tissue softening and also for the maintenance of sutures in such connective tissues. The connective...
|
|
|
6455541 |
Suppression, by 5-lipoxygenase inhibitors, of bone resorption
The present invention focuses upon a method for inhibiting bone resorption. This method involves administering a 5-lipoxygenase inhibitor to a subject in an amount inhibiting the effects of an...
|
|
|
6451839 |
Indole sPLA2 inhibitors
A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
|
|
|
6448285 |
Indolecarboxylic compounds and their use as pharmaceutical compounds
The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this...
|
|
|
6444697 |
Synthetic compounds for treatment of inflammation
Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also...
|
|
|
6444700 |
Product and method to reduce stress induced immune suppression
In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress....
|
|
|
6436984 |
Melatonin derivatives and medicine containing same
The invention concerns melatonin derivatives of formula (I) wherein: R 1 represents H, a C 1 -C 4 alkyl group or a C 1 -C 4 alkoxy group; R 2 represents H or a C 1 -C 4 alkyl group; R 3 ...
|
|
|
6433001 |
1H-indole-3-glyoxylamide sPLA2 inhibitors
A class of novel 1H-indole-3-glyoxylamides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as...
|
|
|
6410584 |
Method for inhibiting neoplastic cells with indole derivatives
A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
|
|
|
6395768 |
Uses for indole-3-propionic acids and salts and esters thereof
The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Furthermore, a...
|
|
|
6391908 |
Oxime amide indole type sPLA2 inhibitors
A class of novel oxime indoles is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
|
|
|
6391917 |
Dialkyl ureas as calcitonin mimetics
Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of...
|
|
|
6387907 |
Use of serotonin agonists to alleviate disordered breathing episodes in a mammal
The invention includes compositions for alleviating or preventing a disordered breathing episode. The composition of the invention comprises a serotonin re-uptake inhibitor, a TRH agonist and an...
|
|
|
6362165 |
Hydroxyphenyl derivatives with HIV integrase inhibitory properties
An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts...
|
|
|
6362236 |
Inhibition of lipoprotein oxidation
Hydroxylated derivatives of cholesterol lowering agents inhibit the oxidation of lipoproteins, and are thus useful for preventing the progression of atherogenesis and resultant vascular diseases,...
|
|
|
6358496 |
Indolin derivatives as sun protection agents
There is described the use of indoline derivatives of formula wherein R 1 is hydrogen; C 1 -C 5 alkyl; C 1 -C 18 alkoxy; or halogen; R 2 is C 1 -C 8 alkyl; C 5 -C 7 cycloalkyl; C 6 -C 10 aryl;...
|
|
|
6350777 |
Description anti-mitotic agents which inhibit tubulin polymerization
Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor...
|
|
|
6342243 |
Method of fattening up a ruminant
An amino acid and/or a peptide are orally administrated to a neonatal ruminant whose fermenting function of the rumen has not yet developed thereby effecting a significant increase in the...
|
|
|
6340699 |
SPLA2 inhibitor compounds for treatment of disease
The present invention is directed to compounds for treating inflammatory bowel disease. More specifically, the present invention is directed to 1H-indole-3-glyoxyamide compounds a sPLA 2 ...
|
|
|
6337344 |
Indole derivatives as inhibitors or factor Xa
The present invention relates to the inhibition of blood clotting proteins, and more particularly, to indole derivatives of formula (I), in which R 1a , R 1b , R 1c R 1d , R 2 , R 3 , R 4 and A...
|
|
|
6337094 |
Aqueous solution for the parenteral nutrition
The invention refers to an aqueous solution for the parenteral nutrition of mammals consisting of: a) a pattern of amino acids calculated on the basis of 100 g/l of amino acids: Isoleucine 4.0-5.5...
|
|
|
6335360 |
Tripeptidyl peptidase inhibitors
The invention is relative to a compound of formula (I) and its use as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the...
|
|
|
6335021 |
Composition for controlling mood disorders in healthy individuals
The use of acetyl L-carnitine and its pharmacologically acceptable salts is disclosed for producing a composition suitable for controlling mood disorders mainly in young individuals who are not...
|
|
|
6335323 |
Compositions for the treatment of peripheral neuropathies containing antidepressants and/or monoamine oxidase inhibitors and/or vitamin B12 and/or precursors or inducers of a neurotransmitter
Methods and compositions for treatment of a patient suffering from a form of peripheral neuropathy are disclosed. The method comprises administering to the patient any one of the following...
|
|
|
6325991 |
Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
The present invention relates to methods of treating periodontal disease in a mammal. The methods include administering to an animal an s effective amount of an inhibitor of sPLA 2 . The inhibitors...
|
|
|
6323234 |
Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
|
|
|
6323235 |
Benzene-condensed heterocyclic derivatives and their uses
Novel compounds having strong TXA 2 receptor antagonist activities and PGI 2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA 2 , are...
|
|
|
6310050 |
Therapeutic use of compounds with β3-agonist activity
The invention relates to the method of use of compounds with B 3 -agonist activity for inhibiting uterine contractions, preventing or slowing down premature labor, or for the treatment and/or...
|
|
|
6310074 |
Substituted dimeric compounds
The invention relates to compound of formula (I): A--G 1 --Cy--G 2 --Cy'--G 3 --B (I) wherein: A represents a grouping NR 1 C(Q)R 2 , C(Q)NR 2 R 3 or NR 1 C(Q)NR 2 R 3 , B...
|
|
|
6306890 |
Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
A compound of the formula ##STR1## where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.
|
|
|
6302837 |
Benzothiophene, benzofuran and indole compounds
A compound selected from those of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR 3 wherein R 3 is as defined in the description, Y represents oxygen, sulphur, NR 3 , or...
|
|
|
6300364 |
Medicinal compositions with cholesterol-lowering effect
Pharmaceutical compositions having a cholesterol-lowering effect which comprises as the active ingredient a compound having a PPAR (peroxisome proliferator-activated receptor)δ activating effect...
|
|
|
6300341 |
2-substituted heterocyclic sulfonamides
The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair...
|
|
|
6300363 |
Indole compounds as COX-2 inhibitors
This invention provides a compound of the following formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C 1 -4 alkylidene; Q...
|
|
|
6288071 |
1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
|
|
|
6277833 |
Substituted triols
Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
|
|
|
6277877 |
Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
Compounds of Formula (I) ##STR1## wherein R 6 is carboxy, (C 1 -C 8 )alkoxycarbonyl, benzyloxycarbonyl, C(O)NR 8 R 9 or C(O)R 12 as glycogen phosphorylase inhibitors, pharmaceutical...
|
|
|
6277878 |
Substituted indole compounds as anti-inflammatory and analgesic agents
This invention provides a compound of the following formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein R 1 is H or C 1 -4 alkyl; R 2 is C(L')R 3 or So 2 R 4 ; Y is a...
|
|
|
6274616 |
N,N-diethylglycolamido ester prodrugs of indole sPLA2 inhibitors
The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl-3-ylmethyl)-2
-methyl-1H-ind ol-4-yl)oxy)acetic acid N,N-diethylglycolamido ester, is disclosed together with its use as a highly...
|
|
|
6271245 |
Hydroxamic acid derivatives
The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such...
|