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6756396 |
Ethylene glycol esters as photoactive agents
New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof wherein each R 1 is independently...
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6756399 |
Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents
The present invention provides a method for treating and preventing an epithelial cell-derived cancer in a subject in need thereof, comprising administering to the subject an amount of a...
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6747053 |
Heteroaryl nitriles
The present invention relates to compound of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or...
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6747052 |
Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: wherein X, Ar 1 , R 2 -R 6 and R 12 ...
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6743770 |
Nutritional supplement for the management of stress
A nutritional supplement to be incorporated into the diet of an individual under stress (e.g., chronic stress) is described, comprising a low-glycemic-index carbohydrate, alpha lactalbumin-enriched...
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6740674 |
Use of proteasome inhibitors to treat dry eye disorders
Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
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6734205 |
Substituted guanidine derivatives
A compound represented by the following formula: wherein R is a substituted or unsubstituted benzene ring, a fused polycyclic hydrocarbon ring which is substituted or unsubstituted, a monocyclic...
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6723744 |
Indole carboxylic acids as thyroid receptor ligands
A compound of the formula wherein W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 13 are as defined herein, useful in the treatment of obesity, overweight condition, hyperlipidemia,...
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6716605 |
Indole derivatives having an antiviral activity
A compound of the formula: wherein R 1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R 2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the...
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6716852 |
Amino acid derivatives and use thereof as NEP, ACE and ECE inhibitors
The invention relates to compounds of formula (I): wherein 0≦n≦3, 0≦m≦6, R 3 and R 4 together form phenyl, B represents heteroaryl, R 1 and R 2 represent hydrogen or groups as...
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6713501 |
Supplement for dialysis patients
Use of a tablet diet supplement for administration to a dialysis patient comprising a mixture of L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-threonine,...
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6706752 |
sPLA2 inhibitors
A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA 2 medicated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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6703412 |
Method of treating sleeplessness with melatonin on an acute basis
A method of treating sleeplessness in a human comprising administering to said human suffering from said sleeplessness an effective sleep-inducing amount of not greater than about 5 mg of melatonin...
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6696479 |
Crystalline forms
Novel crystalline forms of Fluvastatin sodium hydrates were found, referred to hereinafter as polymorphic Forms C, D, E and F. Furthermore, the present invention is directed to processes for the...
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6696481 |
Salt of perindopril and pharmaceutical compositions containing it
The present invention relates to a new salt of perindopril and to pharmaceutical compositions containing it, and Medicaments for treatment of hypertension and heart failure.
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6693096 |
Treatment of inflammation-associated disorders using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a member...
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6670388 |
Fatty acid synthase inhibitors
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
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6660742 |
Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins
The present invention relates to novel achiral seco-analogues of DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II, III, IV...
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6656473 |
Tryptophan source from plants and uses thereof
Compositions are described comprising at least partially defatted meal from a plant source containing protein-bound tryptophan, preferably squash seeds, and, optionally, a carbohydrate source...
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6656964 |
Method of inhibiting phosphodiesterases with substituted alkanohydroxamic acids
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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6656963 |
Indole-3-carbinol (I3C) derivatives and methods
The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and...
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6638963 |
Methods for treating circadian rhythm disorders
A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production so...
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6638966 |
Use of melatonin analogues for induction of general anesthesia
Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
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6630501 |
Phosphinic pseudo-peptides that may be used as matrix zinc metalloprotease inhibitors
The invention relates to pseudo-peptides according to the formula: wherein R 1 is a group inhibiting an amine function, or an amino acid residue or peptide with an inhibited terminal amino...
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6620836 |
Antiarrhythmic and tranquilizer composition and treatment
A composition employing a small amount of the hormone melatonin combined with a magnesium compound is formed into a lozenge or into a timed release tablet to act as an antiarrhythmic agent. As a...
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6620850 |
Materials and methods for treatment of neurological disorders involving overactivation of glutamatergic ionotropic receptors
The subject invention pertains to methods for treatment of neurological conditions related to, or which can be affected by, modulation of glutamate receptor (GluR) activity. The treatment can be...
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6613760 |
Indole derivatives and their use as MCP-1 receptor antagonists
The present invention relates to certain novel compounds, including their production, their formulation as pharmaceutical compositions, and their therapeutic uses. In particular, the invention...
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6613792 |
Treatment of premenstrual syndrome and menopause
A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol;...
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6610729 |
Hydroxamic acid derivatives and medicinal utilization thereof
The present invention relates to a hydroxamic acid derivative of the formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a...
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6610683 |
Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the...
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6610728 |
Method for treatment of non-rheumatoid arthritis
A method is disclosed for the treatment of non-rheumatoid arthritis by administering to a mammal in need thereof a therapeutically effective amount of an sPLA 2 inhibitor.
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6605633 |
IL-8 receptor antagonists
The present invention relates to novel compounds which inhibit the action of CXC chemokines, such as IL-8, Gro, NAP-2, ENA-78 etc., on their receptors, to the process for their preparation and to...
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6602487 |
Methods and tests for producing and for inhibiting coronary artery vasospasms
Methods for producing coronary vasospasms and for inhibiting coronary vasospasms are disclosed. Both in vivo and in vitro methods are disclosed. The methods are useful as tests for determining the...
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6596753 |
Compounds of the indolecarboxylic family and use thereof
The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this...
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6596752 |
Inhibitors of α4β1 mediated cell adhesion
The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of α 4 β 1 mediated adhesion to either VCAM or CS-1 and which can be used for...
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6593347 |
Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
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6589975 |
Synthetic compounds for treatment of inflammation
Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also...
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6589970 |
6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
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6583169 |
N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R 1 and R 2 represents hydrogen or lower alkyl; G, R 3 , R 4 , R 5 , R...
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6579899 |
Composition for treatment of stress
A method of treating stress in a patient showing stress related symptoms is disclosed, where the method comprises administering to the patient an effective amount of a serotoninergic drug or...
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6576638 |
Use of substance P antagonists in the treatment of the adenocarcinomas
It is described the use of antagonists of neuro kynin receptors (NK-1; substance P receptors) in order to establish a new drug effective in the treatment of adenocarcinomas, such antagonists being...
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6576252 |
Anti-stress composition intended for incorporation mainly in nutritional vehicles
A composition to provide a calming stress hormone regulating and immune stimulation effect, which includes a combination of linoleic and linolenic acids, within certain ratios; at least one...
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6569888 |
Anti-inflammatory indole derivatives
Compounds of formula (I) or a pharmaceutically acceptable salt, in vivo hydrolysable ester, or an N—C 1-6 alkyl or N,N-di-(C 1-6 alkyl)amide thereof, where X is CH 2 or SO 2 ; R 1 is an aryl...
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6562858 |
Method for treating depression
The present invention discloses a method for the treatment of depression in a human being identified as having depression. This method comprises the administration of a therapeutically effective...
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6562782 |
Oligocycloalkanoid compounds and methods of use
The present invention related to an oligocycloalkanoid compound comprising formula (I) wherein m, n, and o are independently an integer from 0 to 2; A 1 through A 10 are independently a direct...
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6555569 |
Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection
A pharmaceutical composition containing a glycogen phosphorylase inhibitor of Formula I or IA as defined herein is administered to a mammal to treat infection.
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6555568 |
Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids
Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in...
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6552066 |
Protein tyrosine kinase inhibitors for treating osteoarthritis
Disclosed is a method of treating an individual or animal with osteoarthritis. The method comprises administering to the individual or animal a therapeutically effective amount of a protein...
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6552065 |
Deacetylase inhibitors
The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
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6548521 |
Inhibitors of metazoan parasite proteases
Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one...
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