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4490386 |
Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole -2-carboxylic acids, preparation of, and medical compositions thereof
Phosphate salts of the substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid are produced by treating a suitably substituted octahydro-1H-indole with phosphoric acid. The phosphate...
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4482567 |
N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C 2 -C 16 alkyl, C 3 -C 8 cycloalkyl, C 2 -C 16 ...
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4479963 |
1-Carboxyalkanoylindoline-2-carboxylic acids
1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula ##STR1## R=H, alkyl, alkoxy, halogeno or CF 3 ; R'=H or R-phenyl; m=0 or 1; p,q=0 to 2; and...
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4472387 |
Pharmaceutical compositions capable of increasing cerebral serotonin concentration
A pharmaceutical composition suitable for increasing cerebral serotonin concentration, comprising a serotonin precursor selected from the group consisting of 5-hydroxytryptophan and derivatives of...
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4455316 |
Polyprenyl esters of acemethacins and anti-inflammatory method of use thereof
Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicylic acid, anthranilic acid...
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4451590 |
Organic friction material
Disclosed herein is an organic friction material comprising 5 to 25% by volume of metallic fiber, 3 to 40% by volume of activated carbon, 3 to 15% by volume of carbon fiber, 7 to 47% by volume of...
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4448785 |
N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof
Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. α-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are...
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4444778 |
Method and composition for treating atherosclerosis
A method of improving the arteriosclerotic condition in an animal having arteriosclerosis or having a high risk of developing arteriosclerosis, which method comprises administering an effective...
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4434160 |
Nutrient solution for complete parenteral feeding and for increased energy production
A nutrient solution for complete parenteral feeding and for increased energy production, for administration to patients in the post-aggression phase, which contains, in aqueous solution, per 25...
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4431645 |
Antihypertensive agents
Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 and R 4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B...
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4425355 |
Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-indole with a...
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4419345 |
Sleep-inducing pharmaceutical composition and method
A highly effective sleep-inducing pharmaceutical composition that causes few, if any, side-effects contains an amino acid and a cation in certain proportions. The amino acid may be tryptophan,...
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4412994 |
Mannich-base hydroxamic acid prodrugs, compositions and use
Novel prodrug forms of known non-steroidal anti-inflammatory agents are disclosed, said prodrugs having the structural formula ##STR1##
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4404217 |
3-Indolyl alkylene amino propanols and cardiovascular compositions thereof
The present invention relates to the chemical products of general formula: ##STR1## in which R 1 and R 2 designate hydrogen; halogen, lower alkyl or lower alkoxy; R 3 and R 4 designate...
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4393081 |
Methyl 3-acetamido-2-(5-methoxy-indol-3-yl) propanoate and hypotensive use thereof
Disclosed is the novel compound methyl 3-acetamido-2-(5-methoxyindol-3-yl) propanoate which is useful as an anti-hypertensive agent.
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4378363 |
Certain heterocyclic-carboxamido-phenoxy-aminopropanols, compositions containing same and methods of using same
This invention relates to new aminopropanol compounds having beta-adrenergic activity. In addition, the invention is directed to pharmaceutical compositions containing such compounds for the...
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4377595 |
Process for reducing depression
The level of norepinephrine in neuronal synapses is regulated in order to treat depression by administering a neutral amino acid composition to a human wherein an increased brain level of...
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4363815 |
Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions
Preventive as well as therapeutic treatment to alleviate the symptoms of skin disorders associated with disturbed keratinization or inflammation with one or more alpha or beta hydroxy-acids and...
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4342769 |
2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants
This invention relates to compositions of matter classified in the art of chemistry as substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles, various derivatives thereof, and to the...
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4329356 |
Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane
Fluoxetine alone or a combination of fluoxetine and l-5-hydroxytryptophan, preferably also with a peripheral decarboxylase inhibitor, is administered to hypertensive mammals to lower blood pressure.
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4328309 |
Method for producing tripdiolide, triptolide and celastrol
A process for the production of tripdiolide, triptolide and celastrol comprises the steps of: (a) preparing a cellular inoculum from Tripterygium wilfordii Hook F; (b) inoculating a nutrient growth...
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4299838 |
Tryptophan derivatives having an increased effect on the central nervous system
Tryptophan derivatives represented by the general formula: ##STR1## in which R denotes an acetyl group, M denotes an alkali metal or alkaline-earth metal (more particularly lithium or magnesium)...
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4296119 |
Process and composition for reducing blood pressure in animals
Blood pressure in animals is reduced by administering tyrosine, a tyrosine precursor, tryptophan or mixtures thereof, either alone or in combination with a substance which is known to reduce blood...
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4291048 |
Method of treating tumors and cancerous cachexia with L-tryptophan
A method of inhibiting the growth of tumors by inhibiting gluconeogenesis and thereby interrupting the process of cachexia by the internal administration of compositions containing L-tryptophan to...
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4285962 |
Pharmaceutical compositions having anti-ulcer activity
Pharmaceutical compositions are described which exhibit anti-ulcer activity. They contain as the active ingredient an effective amount of 5-methoxy-2-methyl-3-indolylacetohydroxamic acid of formula...
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4283410 |
3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
Disclosed are compounds characterized by the structural formula: ##STR1## Various compounds circumscribed by the foregoing formula in which: R is H, CH 3 or CH 2 CH 3 , R' is H, or ##STR2## X...
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4255442 |
2-[(Methylsulfinyl)]-3-phenylindoles
This invention relates to 2-[(methylsulfinyl)acetyl]-3-phenylindoles, to derivatives thereof, and to their use in treating rheumatoid arthritis and other disease states susceptible to treatment...
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4252803 |
Indole compounds and use thereof
Compounds are disclosed of general formula (I): ##STR1## wherein R 1 and R 2 each independently represents a hydrogen atom, or an aryl, aralkyl, cycloalkyl, fluoroalkyl or alkyl group, which...
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4235919 |
1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof
The compounds of formula I ##STR1## wherein R is a group ##STR2## wherein A is alkylene of 2 to 5 carbon atoms, X is a bond, oxygen or sulfur, R 3 is hydrogen, hydroxy, alkoxy of 1 to 4...
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4229463 |
Unsaturated fatty acid hydrazides
Mono- or poly-unsaturated fatty acid hydrazides, e.g. cis,-9-octadecenoic acid, 2-(o-methylphenyl)-hydrazide are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g....
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4211782 |
Pharmaceutical combination
Combinations comprising an anti-aggregatory substance together with one or more of an anti-oxidant and a thromboxane A 2 synthetase inhibitor are disclosed. Combinations are useful for the...
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4206220 |
Prodrugs for the improved delivery of non-steroidal anti-inflammatory agents
Novel prodrug forms of carboxylic acid, non-steroidal, anti-inflammatory agents are disclosed, having the structural formula ##STR1## wherein ##STR2## represents the acyloxy residue of any...
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4189494 |
Reducing free fatty acid of the blood and suppressing appetite
The present invention provides a new use of the compounds of formula I, ##STR1## wherein R 1 is lower alkyl, cycloalkyl having 3 to 4 carbon atoms, phenylalkyl of 8 to 10 carbon atoms or...
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4185108 |
Antiosteoporotic agents
It is disclosed that compounds of the formula: ##STR1## wherein Y represents (CO) m in which m has a value of 0 or 1; n has a value of 0 or 1; and X represents S, NH or O; provided that there...
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4181740 |
Indolyl acetic acid derivative
The present invention provides 1-(p-azidobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid and its pharmaceutically acceptable salts and esters and processes of preparation.
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4177277 |
Method for alleviating hypertension
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering an effective amount of a compound having the general formula ##STR1##...
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4161530 |
Pharmaceutical combination preparations as hypnotics
Pharmaceutical Combination Preparations useful as hypnotics which contain as pharmacological active compounds a beta-receptor-blocking compound and L-tryptophane or a non-toxic salt thereof.
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4148895 |
Basically substituted indole derivatives
The present invention relates to basically substituted indole derivatives and to a process for their manufacture. The novel compounds are valuable medicaments which exhibit hypotensive and...
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4105777 |
Indoles
Indoles of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen, halogen, --CF 3 , alkyl of 1 to 8 carbon atoms and alkoxy of 1 to 8 carbon atoms, R 2 is in the 2,3...
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4100160 |
Therapeutic compositions comprising alpha-hydroxy analogs of essential amino acids and their administration to humans for promotion of protein synthesis and suppression of urea formation
Compositions containing the hydroxy analogs of certain essential amino acids are formulated for therapeutic use, particularly in the treatment of renal disorders, hepatic failure and conditions of...
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4100293 |
Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
Treatment of hepatic disorders, such as are characterized by hyperammonemia and portal-systemic encephalopathy, is advocated using compositions comprising keto analogs of certain essential amino...
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4100161 |
Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
Compositions containing the keto analogs of certain of the amino acids essential for humans are therapeutically employed in the treatment of patients confined to low or restricted protein diet,...
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4093733 |
Parenteral suspensions
Improved anti-inflammatory suspensions for parenteral applications, comprising 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl acetic acid as active ingredient.
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4069338 |
Indole derivatives and process for their preparation
Indole derivatives of the formula ##STR1## wherein R 1 , R 2 and R 3 are identical or different and each is H or alkyl of 1 - 6 carbon atoms, R 4 is H or methyl and R 5 is methyl, phenyl or...
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4069337 |
2-Substituted-indole-1-lower-alkanecarboxamides having anti-secretory or anti-ulcer activity
2-Substituted-indole-1-lower-alkanecarboxamides, prepared by amidation of the corresponding acid or ester; by hydrolysis or thiohydrolysis of the corresponding carbonitrile; by alkylation of a...
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4053624 |
Indole-2-carbaldehyde compounds and blood sugar reducing compositions
New indole-2-carbaldehyde compounds of the formula ##STR1## wherein R 1 is lower alkyl R 2 is hydrogen, halogen, or lower alkyl or alkoxy, With the proviso that when R 2 is halogen or...
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4029807 |
Compounds 5-hydroxytryptophan glutamate and its derivatives
The invention relates to the compound 5-Hydroxytryptophan Glutamate, having anti-depressive action.
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4025650 |
Method and composition for preventing nutritional deficiency
A method of providing high-protein nutrition which comprises ingestion of a pre-digested protein composition containing all of the essential amino acids and having a palatable taste and odor.
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4000297 |
N-p-chlorobenzoyl tryptophane, salts and compositions thereof
Pharmaceutically active L-tryptophane compounds comprising the compound of the formula: ##STR1## AND ITS CALCIUM, MAGNESIUM AND ALUMINUM SALTS. These compounds exhibit superior pharmacologic...
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3997670 |
1-Dioxolanylpropyl-3-indoleacrylic acid esters
1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding...
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