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7595339 |
CB1 modulator compounds
Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases...
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7595338 |
Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing...
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7576082 |
Oxindole derivatives
The invention describes compounds of the general formula I
or the pharmaceutically acceptable salts thereof,
wherein R 1 , R 2 , R 3 and X are herein described,
a process for their...
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7560480 |
Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
The present invention relates to alkyl-containing 5-acylindolinones of general formula
wherein R 1 to R 3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures...
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7547703 |
Indoline derivatives substituted in the 6-position, their preparation and their use as medicaments
The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula
in which
R 1 to R 6 and X are as defined in claim 1 , to their tautomers,...
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7517899 |
Phenylaminopropanol derivatives and methods of their use
The present invention is directed to phenylaminopropanol derivatives of formula I:
or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their...
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7514457 |
Substituted aryloxymethyl bicyclicmethyl acetamide compounds
Compounds of the general formula (I):
pharmaceutical compositions comprising a compound of general formula (I); and methods of treating disease conditions caused by overactivation of the VR1...
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7504428 |
2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
The present invention a method of treating anxiety by administering compounds that are active on the GABA B receptor, having formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as...
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7465750 |
Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods
This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a...
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7414054 |
3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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7410994 |
Indole derivatives as anti-inflammatory agents
This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I:
wherein A is a —CH 2 —, —O—, —S—, or...
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7399780 |
3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3
The present invention provides new compounds of formula Ia and Ib: as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said...
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7396852 |
Compound having indolocarbazole moiety and divalent linkage
A compound including at least one type of an optionally substituted indolocarbazole moiety and at least one divalent linkage.
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7378439 |
Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di-n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and...
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7345084 |
Indole derivatives useful as progesterone receptor modulators
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by...
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7342040 |
5-fluorooxindole-3-carboxylic acid ester
A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2):
wherein R 1 is a group selected from the group consisting of an unsubstituted or substituted alkyl group having 1...
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7338966 |
Substituted oxindole derivatives as tyrosine kinase inhibitors
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
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7332516 |
Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
The present invention encompasses compounds of Formula I (I)
or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a...
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7314887 |
Thrombopoietin activity modulating compounds and methods
Disclosed herein are compounds of Formula (I), (II), and (III)
pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same,...
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7307099 |
4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents
This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-die
none compounds, and analogs thereof, including compounds of the following formula, which are, inter...
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7276516 |
CB1 antagonist compounds
Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases...
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7262206 |
Cycloalkyl—containing 5-acylindolinones, the preparation thereof and their use as medicaments
The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula
wherein R 1 to R 3 are defined as in claims 1 to 6 , the tautomers, the enantiomers, the...
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7256186 |
Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula:
wherein:
R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —XC(O)Y,...
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7250442 |
Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising...
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7217733 |
ACE inhibitor derivatives
ACE inhibitor nitroderivatives of formula (I):
A—(X 1 —ONO 2 ) s (I)
...
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7217732 |
Cannabinoid receptor agonists
A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein:
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , L 1 , L 2 , M, n, p, X, Y and Z are as described in the specification;...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7211600 |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers...
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7186745 |
Indolone derivatives having vascular damaging activity
This invention relates to the use of compounds of Formula (I) as vascular damaging agents: wherein X is selected from: —O—, —S—, —S(O)—, —S(O 2 )—, —N(R 5 )—, —C(O)—,...
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7176231 |
Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
The present invention relates to aryl-containing 5-acylindolinones of general formula
wherein R 1 to R 3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures...
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7169803 |
N-substituted prodrugs of fluorooxindoles
The present invention provides novel N-substituted fluorooxindoles having the general Formula I
wherein the wavy bond
represents the racemate, the (R)-enantiomer or the (S)-enantiomer and...
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7166635 |
3-imino-2-indolones for the treatment of depression and/or anxiety
This invention is directed to indolone derivatives which are selective antagonists for the GalR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective...
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7157488 |
N-(2-Arylethyl) benzylamines as antagonists of the 5-HT6 receptor
The present invention provides compounds of formula I
pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT 6 receptor. The...
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7138425 |
Phthalimide carboxylic acid derivatives
The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine,...
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7115649 |
Methods of treating skin disorders using thio-oxindole derivatives
The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein...
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7115647 |
Method of inhibiting neoplastic cells with indole derivatives
A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
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7112603 |
Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions...
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7098236 |
3-(arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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7098234 |
Indole derivatives, process for preparation of the same and use thereof
Indole derivatives represented by formula (I):
(wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an...
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7087627 |
Combinations for the treatment of diseases involving angiogenesis
Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or...
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7084169 |
Aminoalkoxyindoles and methods of use
The invention provides compound of the Formula:
and pharmaceutically acceptable salts or prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , m and n are as defined herein. The invention also...
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7084168 |
Indoline derivatives
This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including...
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7084167 |
Calcium receptor active molecules and method for preparing same
The invention concerns compounds of general formula (I) wherein: the group X represents a —NR4, —CH═N or —CHR5-NR4-group; the group Y represents an oxygen or sulphur atom or a NR, —CR5,...
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7081470 |
Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
This invention is directed to indolone derivatives which are antagonists for the GALR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of...
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7074814 |
3-substituted indoles and derivatives thereof as therapeutic agents
The present invention provides indoles of Formula I:
wherein R 1 and R 2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are...
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7071217 |
Substituted oxindole derivatives as tyrosine kinase inhibitors
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
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7015242 |
Methods for treating hyperactive gastrointestinal motility
This invention provides methods for the treatment or inhibition of hyperactive gastrointestinal motility in a mammal utilizing compounds having the formula:
where R, and R 1 to R 6 are...
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6989401 |
Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic...
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6982275 |
Process for producing optically active sulfoxide derivative
The present invention relates to a production method of an optically active form of a compound represented by formula (II)
wherein ring A is a benzene ring optionally having substituent(s); R 1...
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6969729 |
Use of isatin derivatives as ion channel activating agents
The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of...
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