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4994474 |
Alkyl- or aryl-aminoalkoxy-benzene-sulfonyl indoles
The present invention relates to aminoalkoxyphenyl derivatives of formula: ##STR1## and its N-oxide and pharmaceutically acceptable salts, in which: B represents a--S--, --SO-- or --SO 2 -- group,...
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4985448 |
Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition
Lactam compounds of the formula ##STR1## in which: R is hydrogen, alkyl or cycloalkyl; R 1 is hydrogen, alkyl, alkenyl or cycloalkyl; R 2 is alkyl, alkenyl, cyano or a carbonyl substituted...
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4977153 |
3-aminopropyloxyphenyl derivatives, pharmaceutical compositions containing them and method for the therapy of diseases
Compounds of formula (I), ##STR1## characterized in that R signifies optionally substituted heteroaryl-, heteroarylakyl or heteroarylalkenyl, R 1 signifies hydrogen or a substituent, R 2 is...
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4977178 |
Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side...
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4952598 |
3-phenyl indolinone derivatives, processes for their preparation, medicaments containing them, and their use
Calcium antagonists of the formula ##STR1## with R(1), R(2), R(3) and R(4) being, inter alia, H, alkyl, alkoxy, halogen, in some cases phenyl; m being 1-4; n being 0-3; X being CH 2 , O, S, CO,...
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4952599 |
Phenylthioureas, phenylisothioureas, phenylcarbodiimides, pesticidal compositions containing them and their use in pest control
Novel substituted phenylthioureas, phenylisothioureas and phenylcarbodiimides of formula I ##STR1## wherein R 1 is C 1 -C 10 alkyl, unsubstituted or substituted by one or more halogen atoms...
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4927843 |
Antiviral compositions
The invention relates to novel pharmaceutical compositions which are effective against a wide spectrum of viruses belonging to the Retroviridae family. The active ingredient of the compositions is...
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4912126 |
Producing anxiolytic activity and treating depression with 3(H)-indolones
The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
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4882329 |
Alkoxyphenylindolinone derivatives, medicaments containing them and their use
Calcium antagonists of the formula ##STR1## with R(1), R(2), R(3) and R(4) being, inter alia, H, alkyl, alkoxy, halogen, in some cases phenyl; m being 1-4; n being 0-3; X being CH 2 , O, S, CO,...
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4880805 |
Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R 6 and R 7 are hydrogen or...
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4873259 |
Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
Compounds of the formula: ##STR1## wherein R 1 is (1) hydrogen, (2) C 1 to C 4 alkyl, (3) C 2 to C 4 alkenyl, or (4) NR 2 R 3 , wherein R 2 and R 3 are independently selected from (1)...
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4863948 |
Isoindolinone sulfonamide anti-arrhythmic agents
A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkyl
amine derivatives have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic...
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4863949 |
Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them
The present invention provides compounds of the general formula: ##STR1## wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic radical, A is a straight-chained or branched...
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4861794 |
3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula ##STR1## and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H...
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4853408 |
4-phenylpropyl-indoles having antiarythmic activity
Novel 4-phenylpropyl-indoles of the formula ##STR1## wherein R and R 1 are individually selected from the group consisting of hydrogen, linear alkyl of 1 to 5 carbon atoms, branched alkyl of 3 to...
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4853409 |
3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula ##STR1## and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H...
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4847260 |
Composition for percutaneous administration
A composition for percutaneous administration containing a nicotinic ester represented by formula (I) ##STR1## or an isonicotinic ester represented by formula (II) ##STR2## wherein R and R' each...
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4847283 |
Ointment and method for treating skin lesions due to herpes virus
An ointment containing Indole or an Indole derivative such as Indican or Indomethacin as the active ingredient and a base. Also, a process for treating inflammations and lesions on the human skin...
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4840963 |
2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
Novel 2-sulfamoyl-1H-indoles and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in pharmaceutical compositions designed for systemic or topical...
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4839367 |
Antihypertensive amide compounds
Provided are antihypertensive compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the...
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4826847 |
Beta-blocking oxindole derivatives
The present invention provides oxindole derivatives of the formula: ##STR1## wherein the various substituents are defined hereinbelow. The above compounds display nitrate-like as well as...
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4808609 |
Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmic activity
A compound selected from the group consisting of hydroxyalkoxy-4-phenylpropyl-indoles of the formula ##STR1## wherein R and R 1 are individually selected from the group consisting of hydrogen,...
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4806551 |
N-dihydroindolylethyl-sulphonamides
New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These...
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4791131 |
Analgesic and antiinflammatory 1-acyl-2-oxindole-3-carboxamides
Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and...
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4791129 |
1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents
1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
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4780477 |
Isatin compositions having anti-ulcer activities
This invention provides novel isatin compounds which are useful as therapeutic agents. The invention isatin compounds and the pharmaceutically acceptable salts thereof exhibit anti-ulcer activities...
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4774240 |
N-indolylethyl-sulphonic acid amides and their use
The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined in the specification and X is carboxyl, alkoxycarbonyl,...
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4742077 |
Bicyclic allylether derivatives, processes for their production and their use
Compounds of formula I ##STR1## wherein R 1 represents a group of formula ##STR2## whereby R 4 and R 5 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy or...
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4730004 |
Analgesic and anti-inflammatory 1-acyl-2-oxindole-3-carboxamides
Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and...
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4725616 |
1,3-dicarboxamide-oxindoles as antiinflammatory agents
1,3-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
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4721712 |
1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO)...
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4694017 |
2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity
Novel oxindole derivative and salt thereof represented by the general formula, ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a...
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4686224 |
Oxindole antiinflammatory agents
Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl...
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4678802 |
1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
1-Acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-acylcarbamoyloxindole with an isocyanate in the presence of a basic reagent.
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4654360 |
1,2,3-trisubstituted indoles for treatment of inflammation
Disclosed are compounds of the formula ##STR1## wherein the several groups are defined herein. These compounds are useful for treating inflammation.
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4652581 |
Tetrahydroindole derivative as medicament for cerebral apoplexy
1-Isopropyl-3-hydroxy-5-semicarbazono-6-oxo-2,3,5,6-tetrahyd
roindole, inclusive of pharmacologically acceptable salts thereof, is effective for prophylaxis and treatment of cerebral apoplexy.
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4650811 |
Ethenylphenol-indoles having antiarythmic utility
Novel ethenylphenol indoles of the formula ##STR1## wherein R and R 1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon...
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4642309 |
Indolin-2-one derivatives preparation thereof and intermediates for the preparation thereof
The present invention provides indolin-2-one derivatives of the general formula: ##STR1## wherein R 1 is a C 1 -C 6 alkyl radical or a radical of the general formula: ##STR2## in which A is a...
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4629733 |
Indolinones and pharmaceutical compositions containing same
The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by...
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4624963 |
Use of oxindole compounds for the treatment of epilepsy
Oxindole compounds of the formula I ##STR1## in which R 1 , R 2 , R 3 , R 1 ', R 2 ', R 3 ', R 4 , R 5 and R 6 have the meanings given, and physiologically acceptable salts thereof, for the...
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4588740 |
Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
A series of pharmaceutical compositions which contain 4-aminoalkyl-2(3H)-indolones has been demonstrated to have D 2 -agonist activity useful for treating congestive heart failure and...
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4569942 |
N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted...
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4558048 |
Method of treating diarrhoea using indole compounds
Substituted phenylindoles, useful as anti-diarrhoeal agents and having the formula: ##STR1## and the pharmaceutically-acceptable acid addition salts thereof; wherein R is hydrogen, chloro, bromo,...
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4556672 |
3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and...
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4554288 |
Use of bendazac and its salts in the treatment of retinitis pigmentosa
It was discovered that bendazac, or (1-phenylmethyl-1H-indazol -3-yl)oxy acetic acid, when administered in a form suitable to obtain therapeutic tissue concentrations, determine an improvement in...
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4542148 |
2-Oxo-3-phenyl indole derivatives, drugs having a neuroanabolic action containing them, and their use
Oxindole derivatives of the general formula I ##STR1## are described, and also processes for their preparation and drugs containing them. The new compounds exhibit a neuroanabolic action in various...
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4452808 |
4-Aminoalkyl-2(3H)-indolones
A series of new chemical compounds which are 4-aminoalkyl-2(3H)-indolones has been demonstrated to be D 2 -agonists useful for treating hypertension. A representative compound of the series is...
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4414224 |
Pharmaceutical composition and methods for producing dopamine agonist activity
Methods and compositions using as active ingredients 2-(3H)-indolones whose structures having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus are...
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4378363 |
Certain heterocyclic-carboxamido-phenoxy-aminopropanols, compositions containing same and methods of using same
This invention relates to new aminopropanol compounds having beta-adrenergic activity. In addition, the invention is directed to pharmaceutical compositions containing such compounds for the...
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4374846 |
N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility
Novel N-amino alkyl indole compounds are disclosed. These compounds correspond to the Formula I ##STR1## In said Formula R 1 indicates the hydrogen atom, an alkyl group with 1 to 4 carbon atoms,...
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