Matches 201 - 250 out of 337 < 1 2 3 4 5 6 7 >
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5470878 Cell signaling inhibitors  
Therapeutic compounds have the formula: (X)j-(non-cyclic core moiety), j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate,...
5466443 Herbal-based oral composition and process for producing the same  
An herbal-based oral composition for promoting darkening of human hair color upon periodic retention of the composition within the oral cavity includes an herbal mixture included at a level of from...
5455262 Mercaptosulfide metalloproteinase inhibitors  
Novel mercaptosulfide matrix metalloproteinase inhibitors of the Formula I, ##STR1## wherein: n is 0 or 1; R 1 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl,...
5424329 Indole-2-carboxamides as inhibitors of cell adhesion  
3-Substituted-indole-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory...
5422361 Stable cream and lotion bases for lipophilic drug compositions  
A cosmetically elegant, physically and chemically stable base in the form of an oil-in-water emulsion for use in cream and lotion lipophilic drug containing- pharmaceutical compositions containing...
5407961 α-substituted benzenemethanamine derivatives and pharmaceutical use  
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
5382593 New 3-(hydroxybenzylidenyl)-indolin-2-ones  
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the description, its Z and E isomers, its optical...
5380722 Indole carboxamides  
Novel indole-carboxamides of the formula ##STR1## and their non-toxic pharmaceutically acceptable acid addition salts having remarkable anti-arrhytmic properties.
5374652 2-oxindole compounds which are useful as tyrosine kinase inhibitors  
Aryl- and heteroarylethenylene derivatives of formula ##STR1## wherein Y is a mono- or bicyclic ring system chosen from (A), (B), (C), (D), (E), (F) and (G) ##STR2## R is a group of formula R 1 ...
5373019 Pharmaceutical lactam compositions for inhibition of erythrocyte and thrombocyte aggregation  
The present invention provides compounds and pharmaceutical compositions containing indolones of the general formula: ##STR1## These indolones where no and the pharmaceutical compositions...
5350761 Indolyl substituted hydroxylamine derivatives  
Disclosed are the compound of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C 3 -C 7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl,...
5312820 Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines  
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT 1 and AT 2 activity useful in the treatment of hypertension and...
5308839 Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline  
A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase...
5288749 Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors  
The present invention provides tertiary and secondary amine compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and...
5288743 Indole carboxylate derivatives which inhibit leukotriene biosynthesis  
Compounds of the structure ##STR1## where A is straight or branched divalent alkylene or divalent cycloalkylene, R 1 is selected from hydrogen; alkylthio; optionally substituted phenylthio;...
5284841 Benzo-fused lactams promote release of growth hormone  
There are disclosed certain novel compounds identified as benzo-fused lactams ##STR1## which promote the release of growth hormone in humans and animals. This property can be utilized to promote...
5273993 Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals  
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O) 2 NR 1 R 2 ] z wherein A...
5272170 Tetralones with pharmacological activity  
The present invention relates to new tetralones having the formula I: ##STR1## wherein: R 1 and R 2 represent hydrogen, halogen, cyano, C 1 -4 alkyl, C 1 -4 alkoxy, trifluoromethyl,...
5268385 Method for treating schizophrenia  
This invention provides a method for treating the symptoms of schizophrenia by interacting selectively with presynaptic dopaminergic D 2 receptors without appreciably activating postsynaptic...
5254595 Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them  
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
5250565 Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-inhibiting compounds  
Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula ##STR1## in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted...
5227395 Anti-platelet aggregating agent  
The use of 1-phenoxycarbonyl-2-pyrrolidinone derivatives as an anti-platelet aggregating agent. The derivatives are of the formula ##STR1## wherein R is a C 1 -C 6 alkyl group, a C 1 -C 6 ...
5212320 Indole derivatives and their use for testosterone 5-alpha-reductase-mediated diseases  
Indole derivatives of the formula ##STR1## and pharmaceutical compositions thereof. They are useful for treating or preventing testosterone 5-alpha-reductase-mediated diseases, such as alopecia,...
5206261 Oxindole derivative  
The present invention provides an oxindole derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and...
5198012 Phosphate activators for cyclohexenone herbicides  
A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a...
5198461 Isatine derivatives, their preparation and use  
A method of treatment with compounds having the formula ##STR1## R 1 is hydrogen, C 1 -6 -alkyl which may be branched, C 3 -7 -cycloalkyl, benzyl, phenyl which may be substituted, acyl, hydroxy, C...
5192792 Isatine derivatives, and their method of use  
A method of treatment of central nervous system disorders with compounds having the formula ##STR1## and isomers thereof wherein R 1 , R 2 , R 4 , R 5 , R 6 , and R 7 and as defined in the...
5192791 Fused ring heterocycles and pharmaceutical compositions containing same  
A novel class of pyrrolidin-2-one and piperidin-2-one compounds in which the nitrogen atom is bonded to an oxyphenyl radical having tertiary-alkyl and tri-methylsilyl substituents. The compounds...
5179119 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof  
This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R 1 , R 2 and R 3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or...
5177102 Polyisoprene compounds and salts thereof  
There are given disclosures on a polyisoprene compound of the formula ##STR1## wherein Y is S, O, NH or ##STR2## l is an integer of 2-10, Z is a group of ##STR3## R 1 and R 2 are same or...
5169860 Antitumor compositions and methods of treatment  
This invention provides the use of certain benzofuransulfonamide, benzothiophenesulfonamide, and indolesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided...
5164404 Hydrazone derivatives and their use  
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory...
5155110 Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition  
The present invention is novel selected hydroxamic acid derivatives of fenamic acids having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating...
5137909 Indole derivative and method of production thereof  
An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R 1 , R 2 , R...
5132319 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5132312 Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors  
Disclosed are novel 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy...
5128352 Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides  
Certain N-(substituted)-1-heteroaryl-oxindole-3-carboxamides wherein the N-substituent is thienyl, furyl, phenyl or substituted phenyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and...
5124347 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents  
The present invention is for selected novel compounds which are indoles substituted at the 3-position with [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene as well as pharmaceutical...
5124327 HIV reverse transcriptase  
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds or pharmaceutical...
5122537 Arylvinylamide derivatives and pharmaceutical use  
The invention relates to new arylvinylamide derivatives of formula ##STR1## wherein Y is a bicyclic ring system chosen from (A), (B), (C), (D), and (E); ##STR2## in which m is zero, 1 or 2; R is...
5118703 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides  
Certain enol ethers and esters of the formula ##STR1## where X and Y are each hydrogen, fluoro or chloro; R 1 is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, phenylalkanoyl,...
5114952 Isoquinolinylsulfonamides as anti-arrhythmic agents  
A series of novel alkanesulphonamidophenyl-N-alkyl-N-(heterocyclic-alkyl)alkyl amine derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in...
5086070 4-benzyl-1H-indoles and anti-arrthymic use thereof  
Novel 4-benzyl-1H-indoles of the formula ##STR1## in all diastereoisomeric forms and mixtures thereof having antiarhythmic activity.
5081138 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith  
Compounds having the formula: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5075302 Mercaptoacyl aminolactam endopeptidase inhibitors  
Mercaptoacyl aminolactam inhibitors of endopeptidases of the formula ##STR1## wherein Y is -(CHR 5 ) n (CR 3 R 4 )- or -(CR 3 R 4 ) p X(CR 3 R 4 ) q -, wherein two substituents selected...
5041460 Heter-aliphatic carboxamides  
This invention provides a series of novel heter-aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >CCH--N<, >N--CHC<, >CN--N< and...
5025005 Lipid derivatives, their production and use  
Novel lipid derivatives of the formula ##STR1## [wherein R 1 is alkyl or alkylcarbamoyl; R 2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R 3 is...
5019587 Bicyclic carboxamides, compositions containing same and use thereof  
The present invention provides compounds of the general formula (I) which inhibit the aggregation of erythrocytes or thrombocytes ##STR1## wherein A is hydrogen or C 1 -C 6 -alkyl, C 2 -C 6 ...
5008283 Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase  
This invention relates to the use of tenidap, 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)-indole-1-ca rboxamide, and the pharmaceutically-acceptable base salts thereof to inhibit activation of...
5006547 Tenidap as an inhibitor of the release of elastase by neutrophils  
This invention relates to the use of tenidap, 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)-indole-1-ca rboxamide, and the pharmaceutically-acceptable base salts thereof to inhibit the release...
Matches 201 - 250 out of 337 < 1 2 3 4 5 6 7 >