Matches 151 - 200 out of 337 < 1 2 3 4 5 6 7 >
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5849782 Methods of inhibiting neurodegenerative diseases  
Methods for inhibiting a nitric oxide-mediated pathological condition and a neurodegenerative disease such as Parkinson's disease, Huntington's disease, Alzheimers's disease, and amyotrophic...
5849710 Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors  
The present invention relates to indol-3-ylmethylene-2-oxindole derivatives which are useful as tyrosine kinase inhibitors. The compounds are suitable for use as anti-proliferative agents,...
5849756 Pharmaceutical composition and method for modulating the immune reaction  
Pharmaceutical compositions for the modulation of the immune reaction of warm blooded animals that are derivatives of the 2-oxindole-3-acetic acid or the...
5840745 Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors  
Novel hydrosoluble 3-arylidene-2-oxindole derivatives, having tyrosine kinase inhibitor activity, encompassed by general formula (I), wherein m is zero, 1 or 2; A is a bicyclic ring chosen from...
5834504 3-(2'-halobenzylidenyl)-2-indolinone compounds for the treatment of disease  
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5817690 4-aminoethoxy indolone derivatives  
A compound of the formula I: ##STR1## in which Y is hydrogen, halogen or lower alkoxy; R 1 is hydrogen, lower alkyl or aryl(lower)alkyl; R 2 is hydrogen, lower alkyl or --(CH 2 ) n X p Ar,...
5807883 2-oxoindoline derivative  
Disclosed is a 2-oxoindoline derivative represented by the formula (I): ##STR1## wherein Ring A represents a benzene ring which is substituted in the 5-position or 6-position by a lower alkyl group...
5801181 Amino alcohol substituted cyclic compounds  
Therapeutic compounds have the formula: (X)j--(core moiety), J being an integer from one to three, the core moiety having at least one, five- to seven-membered ring and X being a racemic mixture,...
5795902 3-substituted 2-oxindole-1 carboxamide pharmaceutical compositions  
The present invention relates to a pharmaceutical preparation comprising: (A) at least one triglyceride or propylene glycol diester of fractionated coconut oil fatty acids; and (B) at least one...
5789404 3-substituted 1-arylindole compounds  
3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or...
5783605 Helper inducers for differentiation therapy and chemoprevention of cancer  
Cancer cells are blocked from entering differentiation pathways because of abnormal methylation enzymes, which are responsible for keeping cancer cells in cycling state. Effective differentiation...
5780498 Endothelin receptor antagonists  
The present invention provides novel compounds represented by the general formula I: ##STR1## wherein R 1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a...
5776969 Treatment of sleep disorders  
Disorders of sleep are treated with a combination of a serotonin reuptake inhibitor and a serotonin 1A receptor antagonist.
5776932 1,3,5-tribsubstituted indazole derivatives, processes for preparing, and for pharmacological treatment therewith  
1,3,5-trisubstituted indazole derivatives of the formula ##STR1## wherein R1 is H, (b) a C 1 -6 straight or branched, substituted or unsubstituted alkyl residue, (c) a C 3 -7 cycloalkyl residue,...
5767139 Indoles which have steroid 5-α reductase inhibitory activity  
The present invention provides compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, together with pharmaceutically compositions containing, uses of, processes for...
5766578 Axillary malodor neutralization  
A method of neutralizing axillary malodor by contacting the malodor with a sulfhydryl reactant.
5763465 7-(2-aminoethyl) benzothiazolones  
There are disclosed compounds of formula I, Ar--CH 2 CH 2 --NH--CR 1 R 2 --X--Y I in which Ar represents a group, ##STR1## X represents a C 1 -12 alkylene chain optionally...
5731326 PDGF antagonists II  
Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal a non-peptide PDGF antagonist such as...
5728712 3,4-disubstituted-phenylsulphonamides and their therapeutic use  
3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.
5728723 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present  
The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in...
5721245 4- 3-indolyl!-1H-pyrrolone  
A compound of the formula ##STR1## wherein R is hydrogen or hydroxy, R 1 and R 2 taken together are a group of the formula --(CH 2 ) m -- and R 7 is hydrogen or R 1 and R 7 taken together are...
5714509 Inhibitors of bacterial sialidase and methods of making and using the same  
A sialidase inhibitor of the shown formula I: ##STR1## where dashed lines d 1 and d 2 , X 1 , R 1 , R 2 , R 6 , R 3 , R 4 and R 5 are as described in the specification; or an analog,...
5684034 1H-indole-3-acetamide sPLA.sub.2 inhibitors  
A class of novel 1-indole-3-acetamides represented by the formula; ##STR1## is disclosed together with the use of such indole compounds for inhibiting sPLA 2 mediated release of fatty acids.
5679700 Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents  
Novel phosphinic acid-containing peptidyl compounds of formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis,...
5674888 Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division  
The invention concerns the recognition that certain non-steroidal anti-inflammatory agents can overcome or ameliorate limitations on trabecular meshwork cell division produced by environmental...
5670507 Method for reversing multiple drug resistant phenotype  
There is disclosed a method for reversing the multiple drug resistant (MDR) phenotype in tumors insensitive to hydrophobic chemotherapeutic drugs due to over expression of mdr-1, comprising...
5663188 Synergistic therapeutic compositions of angiotensin I converting enzyme inhibitors and angiotensin II antagonists and methods  
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
5663192 Heterocyclic neuropeptide Y receptor antagonists  
This invention provides methods for treating or preventing a condition associated with an excess of neuropeptide Y which methods comprise administration of one or more substituted benzofurans,...
5658904 1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same  
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
5612368 O-arylmethyl-N-(thio)acylhydroxylamines  
The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar, X, R 1 and R 2 are as defined in the description and a medicinal product containing the same in order...
5610174 Use of α.sub.1A -selective adrenoceptor agonists for the treatment of urinary incontinence  
The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the...
5607959 Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents  
Compounds of formula (I) where R 1 is thienyl, phenyl or furyl, X and Y are halogen or hydrogen and Q is alkoxy or amino are useful as analgesic and antiinflamatory agents. ##STR1##
5602169 3-substituted oxindole derivatives as potassium channel modulators  
There is provided novel substituted 3-phenyl oxindole derivatives of the formula ##STR1## wherein R is hydrogen, hydroxy or fluoro; R 1 , R 2 , R 3 and R 4 each are independently hydrogen,...
5599832 Indoles as insecticides and acaricides  
There are provided methods for the control of insects and the protection of crops from the damage caused thereby which comprise the use of compositions comprising an indole compound of formula I...
5597814 Use of salicylic acid for regulating skin wrinkles and/or skin atrophy  
The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional...
5583130 Benzo-fused lactams promote release of growth hormone  
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth...
5578633 N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present  
The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I)...
5576330 Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents  
The new use of a compound of formula (I) ##STR1## wherein Y is a bicyclic ring selected from naphthalene, tetralin, quinoline, isoquinoline and indole; n is zero or an integer of 1 to 3; R 1 ...
5565484 Benzenesulphonylindole derivatives for the preparation of medicines  
The invention relates to use of at least one indole derivative of general formula: ##STR1## or of one of the pharmaceutically acceptable salts thereof, in which: Am is selected from radical (a) and...
5565460 Therapeutic purine agents for parkinson's disease  
The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound...
5556874 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties  
2-Thioindoles (2-selenoindoles) and analogous 2-indolinethione (2-indolineselenone) and polysulfide (selenide) compounds, salts thereof, methods of production, intermediates in their production,...
5545656 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease  
This invention relates to the use of certain 3-substituted 2-oxindole-1-carboxamides and their pharmaceutically acceptable base salts for the treatment or prevention of Alzheimer's disease in...
RE35279 Hydantoin derivatives  
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives...
5510379 Sulfonate ACAT inhibitors  
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
5502072 Substituted oxindoles  
The present invention relates to novel substituted oxindoles of the formula I as defined below and related compounds, pharmaceutical compositions comprising such compounds, and the use of such...
5498625 Substantially pure enantieners of 2-azabicyclo(2.2.1)hept-5-en-3-one  
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic...
5494928 Indole derivatives  
The invention releates to indole derivatives of the formula ##STR1## wherein R 1 to R 4 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl or trifluoromethyl, R 5 and R 6 are,...
5488057 2-oxindole compounds which have useful tyrosine kinase activity  
The present invention provides novel aryl- and heteroarylethenylene derivatives which are useful as tyrosine kinase activity inhibitors.
5480912 Method of treating HIV-1 with α-substituted benzenemethanamine derivatives  
The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and...
Matches 151 - 200 out of 337 < 1 2 3 4 5 6 7 >