|
Match
|
Document |
Document Title |
|
|
6982275 |
Process for producing optically active sulfoxide derivative
The present invention relates to a production method of an optically active form of a compound represented by formula (II)
wherein ring A is a benzene ring optionally having substituent(s); R 1...
|
|
|
6969729 |
Use of isatin derivatives as ion channel activating agents
The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of...
|
|
|
6964977 |
Oxindole derivatives
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
|
|
|
6930124 |
Compounds derived from oxindoles and their therapeutic application in cancer treatment
The invention relates to compounds of formula (I)
in which R 5 is chosen from the group consisting of:
in which R 2 is a C 1 -C 3 alkyl group
in which X may be Cl, Br, or F
in...
|
|
|
RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
|
|
|
6906090 |
Compositions and methods for treating mycobacterial diseases
The invention provides the use of certain isatin and oxindole derivatives in the preparation of a medicament for use in the treatment of mycobacterial disease.
|
|
|
6878733 |
Formulations for pharmaceutical agents ionizable as free acids or free bases
The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the...
|
|
|
6864277 |
1,3-dihydro-2H-indol-2-one derivatives, method for preparing same and pharmaceutical compositions containing them
The invention relates to compounds of formula:
and to solvates and/or hydrates thereof, with affinity for and selectivity towards the Vreceptors or both the V 1b and V 1a receptors of...
|
|
|
6861442 |
PYK2 and inflammation
The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to...
|
|
|
6858641 |
Substituted indolinones
The present invention relates to indolinones substituted in the 6-position of general formula
wherein
R 1 to R 5 and X are defined as in claim 1, the isomers and the salts thereof,...
|
|
|
6858623 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Het and X are defined herein. The...
|
|
|
6855730 |
3-methylidenyl-2-indolinone modulators of protein kinase
The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore...
|
|
|
6855710 |
Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
The present invention relates to new substituted indolinones of general formula
wherein
X and R 1 to R 5 are defined as in claim 1, the isomers and the salts thereof which have valuable...
|
|
|
6855729 |
Treatment of fibromyalgia and related fatigue syndromes using antagonists or partial agonists of 5HT1a receptors
The present invention provides a method for treating fibromyalgia and/or chronic fatigue syndrome by administering an antagonist or partial agonist of 5HT1 a receptors.
|
|
|
6849654 |
5-methoxy-carbonylamino-N-acetyltryptamine compounds and derivates thereof
Compositions comprising 5-methoxy-carbonylamino-N-acetyltryptamine compounds and derivatives thereof for the treatment of depression are disclosed.
|
|
|
6846839 |
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for...
|
|
|
6815440 |
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course...
|
|
|
6815439 |
Substituted aza-oxindole derivatives
Substituted aza-oxindole derivatives useful as cyclin dependent kinase II inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar...
|
|
|
6800649 |
Method for inhibiting c-jun expression using JAK-3 inhibitors
The invention provides a method for inhibiting c-jun activation in mammalian or avian cells comprising contacting the cells with a substance that inhibits the activity of Janus family kinase 3...
|
|
|
6794395 |
Substituted indolinones, their manufacture and their use as medicaments
The present invention relates to substituted indolinones of general formula wherein R 1 to R 6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the...
|
|
|
6794407 |
Methods for treating circadian rhythm phase disturbances
A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed...
|
|
|
6765012 |
3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
|
|
|
6762180 |
Substituted indolines which inhibit receptor tyrosine kinases
Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells....
|
|
|
6756399 |
Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents
The present invention provides a method for treating and preventing an epithelial cell-derived cancer in a subject in need thereof, comprising administering to the subject an amount of a...
|
|
|
6716870 |
Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions...
|
|
|
6710068 |
Phenylindoles for the treatment of HIV
The invention as disclosed herein is a method and composition for the treatment of HIV in humans and other host animals, that includes the administration of an effective HIV treatment amount of a...
|
|
|
6706751 |
Dihydroindole and tetrahydroquinoline derivatives
The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are...
|
|
|
6696482 |
Formulations for hydrophobic pharmaceutical agents
The present invention features formulations, including liquid, semi-solid or solid pharmaceutical formulations, that improve the oral bioavailability of hydrophobic pharmaceutical agents, such as...
|
|
|
6689806 |
Indolinone compounds as kinase inhibitors
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to...
|
|
|
6670388 |
Fatty acid synthase inhibitors
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
|
|
|
6656964 |
Method of inhibiting phosphodiesterases with substituted alkanohydroxamic acids
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
|
|
|
6642251 |
Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected...
|
|
|
6638963 |
Methods for treating circadian rhythm disorders
A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production so...
|
|
|
6596732 |
1,3-dihydro-2h-indol-2-one, preparation method and pharmaceutical compositions containing same
The invention relates to compounds of formula: and their solvates and/or hydrates exhibiting an affinity and a selectivity for arginine-vasopressin V 1b receptors or for both V 1b and V 1a ...
|
|
|
6576636 |
Method of treating a liver disorder with fatty acid-antiviral agent conjugates
The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.
|
|
|
6576656 |
Oxindole derivative
An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen,...
|
|
|
6566389 |
Therapeutic uses of melatonin
A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an...
|
|
|
6562858 |
Method for treating depression
The present invention discloses a method for the treatment of depression in a human being identified as having depression. This method comprises the administration of a therapeutically effective...
|
|
|
6544970 |
Cyclic regimens utilizing indoline derivatives
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
|
|
|
6514992 |
Caspases and apoptosis
The present invention is to novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of Caspases for use in the treatment of apoptosis, and disease states...
|
|
|
6506763 |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
The present invention relates to novel 3-(substituted)-2-indolinones compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore...
|
|
|
6498176 |
3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase...
|
|
|
6486192 |
Indole compounds useful for treating bacterial infections
This invention relates to the use of certain indole compounds, which are active as inhibitors of the fatty acid synthase FabH, for the treatment of bacterial infections.
|
|
|
6479528 |
Methods for inhibiting or reversing tau filament formation polymerization
Methods for inhibiting and/or reversing tau filament formation or polymerization are provided. These methods can be used for treating certain neurological disorders in vivo by administering...
|
|
|
6472406 |
Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
|
|
|
6469042 |
Fluoro oxindole derivatives as modulators if KCNQ potassium channels
There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I wherein R 1 , R 2 , R 3 and R 4 each are independently hydrogen, C 1-4 alkyl, halogen, fluoromethyl,...
|
|
|
6455541 |
Suppression, by 5-lipoxygenase inhibitors, of bone resorption
The present invention focuses upon a method for inhibiting bone resorption. This method involves administering a 5-lipoxygenase inhibitor to a subject in an amount inhibiting the effects of an...
|
|
|
6436949 |
Heterocyclically substituted benzamides and their use
Heterocyclically substituted benzamides of the formula I are described, where R 1 , R 2 , R 3 , R 4 , R 5 , X, m and n have the meanings given in the description. The novel compounds are useful...
|
|
|
6436965 |
PDE IV inhibiting amides, compositions and methods of treatment
Compounds represented by formula I: as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by...
|
|
|
6410584 |
Method for inhibiting neoplastic cells with indole derivatives
A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
|