Patents in Class 514/416

Matches 1 - 50 out of 209

1 2 3 4 5 >

Match	Document	Document Title
1	7615563	Compositions useful as inhibitors of voltage-gated sodium channels The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
2	7612065	Inhibitors of c-JUN N-terminal kinases (JNK) The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
3	7601729	Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein: A represents bond, C 1-6 alkyl or CH═CH—C 1-4 alkyl; B represents bond, O, S, SO, SO 2 , CO, CR 7 R 8 , CO 2 R 14 , CONR 14 R 15 , N(COR 14 )(COR 15 ),...
4	7589117	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as...
5	7582670	Methods of treating an inflammatory-related disease The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of...
6	7557114	Heterocyclic-substituted phenyl methanones The present invention relates to compounds of formula I wherein R 1 and R 2 are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Compounds of the...
7	7531569	Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which...
8	7528165	Indole compounds This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L 1 , L 2 , R 1...
9	7504427	Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof,...
10	7485643	Bicyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 20 , R 21 , and R 22 are as defined in...
11	7482472	Substituted isoindoles and their use The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and...
12	7482336	Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment...
13	7468387	Crystalline forms of imidoalkanpercarboxylic acids Imidoalkancarboxylic acids of formula (I) are described, wherein A, X and M are as defined in the application, said acids being in a crystalline form which in contact with water gives rise to...
14	7456183	Guanidino compounds Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, S═O, SO 2 , S, O, (CR 6 R 7 ) n ,...
15	7427638	(+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:, and methods of synthesis and compositions thereof Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4 -acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs,...
16	7417063	Bicyclic heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, L 1 , L 2 , X 1 , X 2 , X 3 ,...
17	7405237	Isoindoline compounds and methods of their use Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases...
18	7390821	Methods of reducing angiogenesis The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
19	7378438	Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory...
20	7354948	Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
21	7348352	Diindolylmethane for the treatment of HPV infection New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized...
22	7345062	Substituted acylhydroxamic acids and method of reducing TNFαlevels Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
23	7320992	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
24	7276518	Substituted cyclohexane-1,4-diamine compounds Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds.
25	7268147	Compounds useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
26	7262208	Hydroxypropyl amides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
27	7244759	Isoindoline compounds and methods of making and using the same The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders....
28	7220775	Compound useful for the treatment of neuropathic pain This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor and are useful for the treatment of neuropathic pain and other abnormalities....
29	7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G...
30	7192968	Ethylenediamine derivatives The invention relates a compound represented by the formula (1): Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 ( 1...
31	7160917	Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof The present invention relates to spirobenzofuran lactam derivatives of the formula I which are formed during fermentation by the microorganism Stachybotris atra ST002348, DSM 14952, processes...
32	7115647	Method of inhibiting neoplastic cells with indole derivatives A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
33	7112602	Methods of treating undesired angiogenesis with 2-methyl-EM-138 The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric....
34	7109243	Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
35	7101867	Benzofuran derivatives, their production and use Compounds represented by the formula: wherein R 1 and R 2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R 1 and R 2 may form, together with the adjacent carbon atom, a...
36	7098235	Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds Prodrugs of glycogen phosphorylase inhibiting compounds are provided which are useful in treating diabetes, having the formula I G(—O 2...
37	7078428	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as...
38	7078400	20-HETE synthase inhibitor The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
39	7056932	Heterocyclyl substituted 1-alkoxy acetic acid amides The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R 1 to R 6 and A are as defined in the description and in the claims, as...
40	7045534	Methods of reducing angiogenesis The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
41	7037901	Radiosensitization by indolocarbazole derivatives The present invention is based on the discovery of a composition that provides radiosensitization effect. Specifically the composition contains an indolocarbazole derivative. The present invention...
42	7008636	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance...
43	6977268	Methods and compositions for inhibition of angiogenesis with EM-138 The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs,...
44	6936606	Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 and X are defined herein. The...
45	6911464	N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel N-alkyl-hydroxamic acid-isoindolyl compounds, pharmaceutical compositions of these compounds, and methods of using these compounds and compositions for treatment or...
46	6900194	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of...
47	6864254	Inhibitor for 20-hete-yielding enzyme An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
48	6849655	Aqueous liquid formulations An aqueous liquid formulation which comprises a compound of formula I: wherein Y is a hydroxy group, a carboxyl group, an acyloxy group or an alkoxycarbonyl group; R is a lower alkyl group or...
49	6846832	2,3-dihydro-isoindol-1-one derivatives 2,3-Dihydro-isoindol-1-one derivatives, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them, for the prevention and treatment of diseases...
50	6806285	5-Hydroxyl indole derivatives for treating glaucoma Novel 3-(2-aminopropyl)-H-indol-5-ols useful for lowering and controlling IOP and treating glaucoma are disclosed.

Matches 1 - 50 out of 209

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