Patents in Class 514/415

Matches 1 - 50 out of 881

Match	Document	Document Title
1	7619095	Process for the preparation of indolone derivative A process for the preparation of 4-[2-(Di-n-propylamino)ethyl]-2,3-dihydro-1H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formula I involving new intermediates of...
2	7618967	Indane compounds The invention provides novel indane compounds which are useful in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD), cognitive disorders,...
3	7612099	Vinylogous acid derivatives The invention is concerned with vinylogous acids derivatives of formula (I) wherein A and R 1 to R 6 are as defined in the description and in the claims, as well as physiologically acceptable...
4	7612065	Inhibitors of c-JUN N-terminal kinases (JNK) The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
5	7608723	Indole and benzimidazole derivatives The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
6	7608634	Substituted pyrrolines as kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating...
7	7605168	PDE4B inhibitors Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for...
8	7601751	Indole acetic acid acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and...
9	7601750	Small molecule inhibition of a PDZ-domain interaction Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and...
10	7595343	Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
11	7592373	Amide compounds with MCH antagonistic activity and medicaments comprising these compounds Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R 1 , R 2 , and R 3 have the meanings given in claim 1 , pharmaceutical compositions these compounds, and methods of preventing or...
12	7582773	Substituted phenyl indoles The present invention relates generally to substituted phenyl indoles and methods of using them, for example as PAI-1 inhibitors.
13	7582770	Viral polymerase inhibitors An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
14	7582672	Compounds for the treatment of CRTH2-mediated diseases and conditions The present invention provides indole derivatives that antagonize prostaglandin D 2 , and that can be used to treat inflammatory diseases mediated by prostaglandin D 2 .
15	7582670	Methods of treating an inflammatory-related disease The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of...
16	7572806	PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
17	7572782	Use of targeted oxidative therapeutic formulation in bone regeneration A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an...
18	7566736	Substituted indoles, compositions containing them, method for the production thereof and their use Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them,...
19	7563817	Purified 2-aryl-3,3-bis(hydroxyaryl)phthalimidines A method for purifying a 2-aryl-3,3-bis(hydroxyaryl)phthalimidine comprises contacting a crude 2-aryl-3,3-bis(hydroxyaryl)phthalimidine with a purification agent, removing a...
20	7560483	Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
21	7560473	Amine derivative with potassium channel regulatory function, its preparation and use The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions...
22	7557135	Inhibitors of cytosolic phospholipase A₂ This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A 2 enzymes (cPLA 2 ), more particularly including inhibitors of...
23	7550499	Urea antagonists of P2Y₁receptor useful in the treatment of thrombotic conditions The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The...
24	7541358	1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
25	7534897	Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. ...
26	7534809	Phospho-indoles as HIV inhibitors 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in...
27	7531670	Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the...
28	7524863	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
29	7524839	Compounds, their use and preparation The invention-provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): in which Ar, R 2 , R 3 , R 4 and R 5 are as defined in...
30	7524516	Corrosion inhibiting mildew remover kit The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The premeasured...
31	7521472	Crystal of two-ring heterocyclic sulfonamide compound Novel β-type crystal of N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide of the formula: characterized in, for example, that in powder X-ray diffractometry, it has a diffraction peak at a...
32	7517906	Dimeric IAP inhibitors Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the...
33	7511072	7-amido-isoindolyl compounds and methods of its use The invention encompasses 7-amido-isoindolyl compounds and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders....
34	7507758	4-alkyl-/4-alkenyl-/4-alkynyl methyl/-1-aryl-cyclohexylamine compounds 4-alkyl/4-alkenyl/4-alkynyl methyl/-1-arylcyclohexylamine compounds corresponding to the formula I a method for producing them, pharmaceutical compositions containing them, and methods of using...
35	7504431	Sulfonyl amide inhibitors of calcium channel function Compounds of formula I its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in...
36	7504427	Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof,...
37	7504401	Anti-cancer agents and uses thereof The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates,...
38	7494670	Composition and process for removing and preventing mildew and fungal growth This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal...
39	7491831	PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
40	7488749	Therapy of diseases of the eye, the inner ear and the central nervous system The present invention relates to 5,6-dihydroxyindole (DHI), 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and/or 5-S-cysteinyldopa (CD) as medicaments, as well as their use, and the use of...
41	7488468	Near infrared fluorescent contrast agent and fluorescence imaging A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near...
42	7485651	Compounds with activity on muscarinic receptors Compounds and methods are provided for the alleviation or treatment of diseases or conditions in which modification of muscarinic m1 receptor activity has a beneficial effect. In the method, a...
43	7485641	Substituted 3-amino-pyrrolidino-4-lactams The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R 1 , n and R 2 are as described herein; compositions thereof; and uses thereof.
44	7482472	Substituted isoindoles and their use The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and...
45	7476690	Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of...
46	7476676	Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3β This invention relates to the use of inhibitors of glycogen synthase kinase-3β to increase bone formation.
47	7462640	Indol-6yl sulfonamide derivatives, their preparation and their use as 5-HT-6 as modulators The present invention refers to new sulfonamide derivatives, of general formula (Ia, Ib, Ic) optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their...
48	7459585	Benzene derivatives and pharmaceutical use thereof The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
49	7459478	Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula (I) and II) are provided wherein: X is an alkali metal or a basic amine moiety; R 1 is alkyl, cycloalkyl, —CH 2 -cycloalkyl, pyridinyl, —CH 2 -pyridinyl, phenyl or...
50	7456209	IAP binding compounds IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in...

Matches 1 - 50 out of 881

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